Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1983 2017

  • 2069 引用
  • 27 h指数
  • 49 記事
  • 2 評論記事
2017
21 引用 (Scopus)

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism

Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, Y., Omura, M., Nishikawa, T. & Mukai, K., 2 5 2017, : : Molecular and Cellular Endocrinology. 441, p. 124-133 10 p.

研究成果: ジャーナルへの寄稿評論記事

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Steroid 11-beta-Hydroxylase
Zona Glomerulosa
Aldosterone
2014
69 引用 (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., 7 2014, : : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

研究成果: ジャーナルへの寄稿記事

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
2013
4 引用 (Scopus)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., 8 13 2013, : : Reproductive Biology and Endocrinology. 11, 1, 76.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Progesterone
Estradiol
Aldosterone
Steroid 11-beta-Hydroxylase
19 引用 (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., 4 1 2013, : : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

研究成果: ジャーナルへの寄稿記事

Hyperaldosteronism
Aldosterone
Immunohistochemistry
Adenoma
Hyperplasia
2012
28 引用 (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., 9 25 2012, : : PloS one. 7, 9, e45612.

研究成果: ジャーナルへの寄稿記事

Selenium Compounds
Corneal Epithelium
Lactoferrin
Oxidative stress
selenium
2010
151 引用 (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., 5 2010, : : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
2008
10 引用 (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., 7 1 2008, : : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

研究成果: ジャーナルへの寄稿記事

Cytochromes
Lyases
Androstenedione
Rats
Pancreas
2007
21 引用 (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., 2 1 2007, : : Journal of bacteriology. 189, 3, p. 844-850 7 p.

研究成果: ジャーナルへの寄稿記事

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
15 引用 (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., 10 1 2007, : : Journal of biochemistry. 142, 4, p. 453-458 6 p.

研究成果: ジャーナルへの寄稿記事

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats
91 引用 (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., 11 13 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

研究成果: ジャーナルへの寄稿記事

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone
4 引用 (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., 6 1 2007, : : Journal of biochemistry. 141, 6, p. 889-895 7 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
26 引用 (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., 3 13 2007, : : Life Sciences. 80, 14, p. 1259-1267 9 p.

研究成果: ジャーナルへの寄稿記事

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
2005
5 引用 (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., 12 9 2005, : : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex
8 引用 (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., 2 1 2005, : : Biochemical Journal. 385, 3, p. 755-761 7 p.

研究成果: ジャーナルへの寄稿記事

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
2004
3 引用 (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., 12 1 2004, : : Endocrine Research. 30, 4, p. 639-644 6 p.

研究成果: ジャーナルへの寄稿記事

Zona Glomerulosa
Adrenal Cortex
Mitochondrial Membranes
Cytochromes
monodehydroascorbate reductase (NADH)
2003
35 引用 (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., 6 6 2003, : : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

研究成果: ジャーナルへの寄稿記事

Cytochromes b5
Leydig Cells
Mitochondrial Membranes
Modulators
Androgens
2001
23 引用 (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., 1 19 2001, : : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

研究成果: ジャーナルへの寄稿記事

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine
5 引用 (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., 1 1 2001, : : Journal of biochemistry. 130, 4, p. 497-502 6 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
2000
37 引用 (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., 11 3 2000, : : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

研究成果: ジャーナルへの寄稿記事

Protein Precursors
Glycine
Mutation
Enzymes
Peptides
1999
8 引用 (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
1998
21 引用 (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., 12 4 1998, : : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

研究成果: ジャーナルへの寄稿記事

Substrates
Peptides
Arginine
Protein Precursors
mitochondrial processing peptidase
31 引用 (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., 12 4 1998, : : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

研究成果: ジャーナルへの寄稿記事

Glutamic Acid
Substrates
Peptides
Glutamates
Mutation
16 引用 (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates
37 引用 (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., 9 25 1998, : : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

研究成果: ジャーナルへの寄稿記事

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
1997

Processing of mitochondrial protein precursors

Ito, A., Ogishima, T. & Kitada, S., 1 1 1997, : : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 14 Suppl, p. 2362-2367 6 p.

研究成果: ジャーナルへの寄稿評論記事

Metalloendopeptidases
Protein Precursors
Mitochondrial Proteins
Mitochondria
22 引用 (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., 1 1 1997, : : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

研究成果: ジャーナルへの寄稿記事

Malate Dehydrogenase
Arginine
Peptides
Substrates
Protein Precursors
1996
11 引用 (Scopus)

Evidence for 54-kD protein in chicken kidney as a cytochrome P450 with a high molecular activity of 25-hydroxyvitamin D3 1β-hydroxylase

Wakino, S., Meguro, M., Suzuki, H., Saruta, T., Ogishima, T., Shimada, H., Ishimura, Y., Shinki, T. & Suda, T., 1 1996, : : Gerontology. 42, 1, p. 67-77 11 p.

研究成果: ジャーナルへの寄稿記事

Calcifediol
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Chickens
Kidney
31 引用 (Scopus)

Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase

Song, M. C., Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., 1 1 1996, : : Journal of biochemistry. 120, 6, p. 1163-1166 4 p.

研究成果: ジャーナルへの寄稿記事

Basic Amino Acids
Ornithine-Oxo-Acid Transaminase
Peptides
Substrates
Processing
1995
46 引用 (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., 12 22 1995, : : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

研究成果: ジャーナルへの寄稿記事

Arginine
Peptide Hydrolases
Proline
Glycine
Substrates
56 引用 (Scopus)

A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity

Kitada, S., Shimokata, K., Niidome, T., Ogishima, T. & Ito, A., 1 1 1995, : : Journal of biochemistry. 117, 6, p. 1148-1150 3 p.

研究成果: ジャーナルへの寄稿記事

Rats
Catalyst activity
Metals
Binding Sites
Catalytic Domain
30 引用 (Scopus)

Localization of p450aldo and p45011β in normal and regenerating rat adrenal cortex

Mitani, F., Ogishima, T., Miyamoto, H. & Ishimura, Y., 1 1 1995, : : Endocrine Research. 21, 1-2, p. 413-423 11 p.

研究成果: ジャーナルへの寄稿記事

Adrenal Cortex
Zona Glomerulosa
Zona Fasciculata
Corticosterone
Aldosterone
1994
128 引用 (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., 7 1994, : : Endocrinology. 135, 1, p. 431-438 8 p.

研究成果: ジャーナルへの寄稿記事

Adrenal Cortex
Adrenal Cortex Hormones
Enzymes
Cytochrome P-450 CYP11B2
Zona Fasciculata
60 引用 (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., 1 1 1994, : : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

研究成果: ジャーナルへの寄稿記事

Arginine
Demonstrations
Peptides
Substrates
Amino Acids
1993
14 引用 (Scopus)

Molecular Cloning of the Smaller Subunit (P52) of Rat Liver Mitochondrial Processing Protease

Kitada, S., Niidome, T., Nagano, T., Ogishima, T. & Ito, A., 1 1 1993, : : Biochemical and Biophysical Research Communications. 190, 1, p. 289-293 5 p.

研究成果: ジャーナルへの寄稿記事

Cloning
Molecular Cloning
Liver
Yeast
Rats
35 引用 (Scopus)

Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour

Shibata, H., Suzuki, H., Ogishima, T., Ishimura, Y. & Saruta, T., 1 1 1993, : : Acta Endocrinologica. 128, 3, p. 235-242 8 p.

研究成果: ジャーナルへの寄稿記事

Glandular and Epithelial Neoplasms
Adenoma
Aldosterone
Enzymes
Cushing Syndrome
1992
28 引用 (Scopus)

Effect of dietary sodium restriction on mrna for aldosterone synthase cytochrome P-450 in rat adrenals

Imai, M., Ogishima, T., Shimada, H. & Ishimura, Y., 4 1992, : : Journal of biochemistry. 111, 4, p. 440-443 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Dietary Sodium
Cytochromes
Rats
Sodium
154 引用 (Scopus)

Zone-specific expression of aldosterone synthase cytochrome p-450 and cytochrome p-45011β in rat adrenal cortex: Histochemical basis for the functional zonation

Ogishima, T., Suzuki, H., Hata, J. I., Mitani, F. & Ishimura, Y., 5 1992, : : Endocrinology. 130, 5, p. 2971-2977 7 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Adrenal Cortex
Cytochromes
Zona Glomerulosa
Aldosterone
1991
124 引用 (Scopus)

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T. & Ishimura, Y., 9 6 1991, : : Journal of Biological Chemistry. 266, 17, p. 10731-10734 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Cytochrome P-450 Enzyme System
Genes
Aldosterone
56 引用 (Scopus)

Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium

Shibata, H., Ogishima, T., Mitani, F., Suzuki, H., Murakami, M., Saruta, T. & Ishimura, Y., 5 1 1991, : : Endocrinology. 128, 5, p. 2534-2539 6 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Angiotensin II
Potassium
Diet
Aldosterone
26 引用 (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., 11 14 1991, : : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

研究成果: ジャーナルへの寄稿記事

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays
1990
87 引用 (Scopus)

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T. & Ishimura, Y., 4 24 1990, : : FEBS Letters. 263, 2, p. 299-302 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Cloning
Adrenal Cortex
Molecular Cloning
Rats
1989
117 引用 (Scopus)

Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex

Ogishima, T., Mitani, F. & Ishimura, Y., 1989, : : Journal of Biological Chemistry. 264, 19, p. 10935-10938 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Zona Glomerulosa
Mitochondria
Adrenal Cortex
Rats
63 引用 (Scopus)

Isolation of two distinct cytochromes P-45011β with aldosterone synthase activity from bovine adrenocortical mitochondria

Ogishima, T., Mitani, F. & Ishimura, Y., 1 1 1989, : : Journal of biochemistry. 105, 4, p. 497-499 3 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP11B2
Mitochondria
Cytochromes
Desoxycorticosterone
Hydroxylation
1987
52 引用 (Scopus)

Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes.

Ogishima, T., Deguchi, S. & Okuda, K., 6 5 1987, : : Journal of Biological Chemistry. 262, 16, p. 7646-7650 5 p.

研究成果: ジャーナルへの寄稿記事

Cholesterol 7-alpha-Hydroxylase
Liver Microsomes
Liver
Purification
Hydroxylation
1986
89 引用 (Scopus)

An improved method for assay of cholesterol 7α-hydroxylase activity

Ogishima, T. & Okuda, K., 1 1 1986, : : Analytical Biochemistry. 158, 1, p. 228-232 5 p.

研究成果: ジャーナルへの寄稿記事

Cholesterol 7-alpha-Hydroxylase
Assays
Cholesterol Oxidase
Cholesterol
Hydroxycholesterols
1985
48 引用 (Scopus)

Effects of synthetic model peptides resembling the extension peptides of mitochondrial enzyme precursors on import of the precursors into mitochondria

Ito, A., Ogishima, T., Ou, W., Omura, T., Aoyagi, H., Lee, S., Mihara, H. & Izumiya, N., 1 1 1985, : : Journal of Biochemistry. 98, 6, p. 1571-1582 12 p.

研究成果: ジャーナルへの寄稿記事

Enzyme Precursors
Mitochondria
Peptides
Basic Amino Acids
Membranes
35 引用 (Scopus)

Import and processing of the precursor of cytochrome P-450(SCC) by bovine adrenal cortex mitochondria

Ogishima, T., Okada, Y. & Omura, T., 1 1 1985, : : Journal of biochemistry. 98, 3, p. 781-791 11 p.

研究成果: ジャーナルへの寄稿記事

Mitochondria
Adrenal Cortex
Cytochrome P-450 Enzyme System
Membranes
Processing
1984
6 引用 (Scopus)

Fractionation of mammalian tissue mRNAs by high-performance gel filtration chromatography

Ogishima, T., Okada, Y. & Omura, T., 5 1 1984, : : Analytical Biochemistry. 138, 2, p. 309-313 5 p.

研究成果: ジャーナルへの寄稿記事

Fractionation
Chromatography
Gel Chromatography
Gels
Tissue
41 引用 (Scopus)

Interaction between cytochrome P-450 (P-450(C21)) and NADPH-cytochrome P-450 reductase from adrenocortical microsomes in a reconstituted system

Kominami, S., Hara, H., Ogishima, T. & Takemori, S., 1 1 1984, : : Journal of Biological Chemistry. 259, 5, p. 2991-2999 9 p.

研究成果: ジャーナルへの寄稿記事

NADPH-Ferrihemoprotein Reductase
Microsomes
Cytochrome P-450 Enzyme System
Hydroxylation
Oxidoreductases
4 引用 (Scopus)

Presence of a prepiece at the NH2-terminai end of pre-cytochrome P-450(SCC) peptide

Ogishima, T., Okada, Y. & Omura, T., 1 1 1984, : : Journal of biochemistry. 95, 5, p. 1525-1528 4 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 Enzyme System
Peptides
Radio
Amino Acids
Acids