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研究成果 1992 2019

  • 3332 引用
  • 23 h指数
  • 84 記事
  • 4 会議での発言
  • 1 Conference article
  • 1 評論記事
フィルター
記事
2019
1 引用 (Scopus)

Modification of carbon metabolism in Synechococcus elongatus PCC 7942 by cyanophage-derived sigma factors for bioproduction improvement

Sawa, N., Tatsuke, T., Ogawa, A., Hirokawa, Y., Osanai, T. & Hanai, T., 2 1 2019, : : Journal of Bioscience and Bioengineering. 127, 2, p. 256-264 9 p.

研究成果: ジャーナルへの寄稿記事

Synechococcus
Sigma Factor
Metabolism
Bacteriophages
Carbon

Synthetic microbial consortium with specific roles designated by genetic circuits for cooperative chemical production

Honjo, H., Iwasaki, K., Soma, Y., Tsuruno, K., Hamada, H. & Hanai, T., 9 1 2019, : : Metabolic Engineering. 55, p. 268-275 8 p.

研究成果: ジャーナルへの寄稿記事

Microbial Consortia
Enzymes
Networks (circuits)
Microorganisms
Metabolic Networks and Pathways
2018
2 引用 (Scopus)

Mutations responsible for alcohol tolerance in the mutant of Synechococcus elongatus PCC 7942 (SY1043) obtained by single-cell screening system

Hirokawa, Y., Kanesaki, Y., Arai, S., Saruta, F., Hayashihara, K., Murakami, A., Shimizu, K., Honda, H., Yoshikawa, H. & Hanai, T., 5 1 2018, : : Journal of Bioscience and Bioengineering. 125, 5, p. 572-577 6 p.

研究成果: ジャーナルへの寄稿記事

Synechococcus
Screening
Alcohols
Mutation
2-Propanol
2017
4 引用 (Scopus)

Alcohol-tolerant mutants of cyanobacterium Synechococcus elongatus PCC 7942 obtained by single-cell mutant screening system

Arai, S., Hayashihara, K., Kanamoto, Y., Shimizu, K., Hirokawa, Y., Hanai, T., Murakami, A. & Honda, H., 8 1 2017, : : Biotechnology and Bioengineering. 114, 8, p. 1771-1778 8 p.

研究成果: ジャーナルへの寄稿記事

Synechococcus
2-Propanol
Cyanobacteria
Screening
Alcohols
7 引用 (Scopus)
Dihydroxyacetone Phosphate
Synechococcus
Photosynthesis
Cyanobacteria
Lactic Acid
10 引用 (Scopus)
Synechococcus
Cyanobacteria
Metabolic Networks and Pathways
Glycerol
Gene expression
12 引用 (Scopus)

Metabolic engineering for isopropanol production by an engineered cyanobacterium, Synechococcus elongatus PCC 7942, under photosynthetic conditions

Hirokawa, Y., Dempo, Y., Fukusaki, E. & Hanai, T., 1 1 2017, : : Journal of Bioscience and Bioengineering. 123, 1, p. 39-45 7 p.

研究成果: ジャーナルへの寄稿記事

Metabolic engineering
Synechococcus
Metabolic Engineering
2-Propanol
Cyanobacteria
6 引用 (Scopus)
Metabolic engineering
Synechococcus
Metabolic Engineering
Glycerol
Computer Simulation
10 引用 (Scopus)
Cell growth
Metabolic Networks and Pathways
Fermentation
gamma-Aminobutyric Acid
Escherichia coli
8 引用 (Scopus)
Acetyl Coenzyme A
2-Propanol
Pyruvic Acid
Escherichia coli
Switches
2016
5 引用 (Scopus)

A single cell culture system using lectin-conjugated magnetite nanoparticles and magnetic force to screen mutant cyanobacteria

Arai, S., Okochi, M., Shimizu, K., Hanai, T. & Honda, H., 1 1 2016, : : Biotechnology and Bioengineering. 113, 1, p. 112-119 8 p.

研究成果: ジャーナルへの寄稿記事

Magnetite Nanoparticles
Magnetite nanoparticles
Cyanobacteria
Cell culture
Lectins
31 引用 (Scopus)

Cyanobacterial production of 1,3-propanediol directly from carbon dioxide using a synthetic metabolic pathway

Hirokawa, Y., Maki, Y., Tatsuke, T. & Hanai, T., 3 1 2016, : : Metabolic Engineering. 34, p. 97-103 7 p.

研究成果: ジャーナルへの寄稿記事

Metabolic Networks and Pathways
Glycerol
Carbon Dioxide
Coenzymes
Carbon dioxide
2015
20 引用 (Scopus)

Dual synthetic pathway for 3-hydroxypropionic acid production in engineered Escherichia coli

Honjo, H., Tsuruno, K., Tatsuke, T., Sato, M. & Hanai, T., 8 1 2015, : : Journal of Bioscience and Bioengineering. 120, 2, p. 199-204 6 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli
Aldehyde Dehydrogenase
Acids
Aldehydes
Klebsiella pneumoniae
15 引用 (Scopus)

Enhancement of 3-hydroxypropionic acid production from glycerol by using a metabolic toggle switch

Tsuruno, K., Honjo, H. & Hanai, T., 10 5 2015, : : Microbial Cell Factories. 14, 1, 155.

研究成果: ジャーナルへの寄稿記事

Glycerol
Switches
Acids
Metabolism
hydracrylic acid
28 引用 (Scopus)

Optimization of isopropanol production by engineered cyanobacteria with a synthetic metabolic pathway

Hirokawa, Y., Suzuki, I. & Hanai, T., 1 1 2015, : : Journal of Bioscience and Bioengineering. 119, 5, p. 585-590 6 p.

研究成果: ジャーナルへの寄稿記事

2-Propanol
Cyanobacteria
Metabolic Networks and Pathways
Solar Energy
Synechococcus
45 引用 (Scopus)
2-Propanol
Gene expression
Cell Count
Sensors
Quorum Sensing
2014
83 引用 (Scopus)

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

Soma, Y., Tsuruno, K., Wada, M., Yokota, A. & Hanai, T., 1 1 2014, : : Metabolic Engineering. 23, p. 175-184 10 p.

研究成果: ジャーナルへの寄稿記事

Metabolic Networks and Pathways
Carbon Cycle
2-Propanol
Switches
Fluxes
4 引用 (Scopus)

Micro-compartmentalized cultivation of cyanobacteria for mutant screening using glass slides with highly water-repellent mark

Arai, S., Okochi, M., Hanai, T. & Honda, H., 12 1 2014, : : Biotechnology Reports. 4, p. 151-155 5 p.

研究成果: ジャーナルへの寄稿記事

Cyanobacteria
Glass
Water
Biofuels
Cell Separation
2013
76 引用 (Scopus)

Engineering a synthetic pathway in cyanobacteria for isopropanol production directly from carbon dioxide and light

Kusakabe, T., Tatsuke, T., Tsuruno, K., Hirokawa, Y., Atsumi, S., Liao, J. C. & Hanai, T., 1 1 2013, : : Metabolic Engineering. 20, p. 101-108 8 p.

研究成果: ジャーナルへの寄稿記事

Coenzyme A-Transferases
Clostridium
2-Propanol
Cyanobacteria
acetoacetate decarboxylase
2012
38 引用 (Scopus)

Direct isopropanol production from cellobiose by engineered Escherichia coli using a synthetic pathway and a cell surface display system

Soma, Y., Inokuma, K., Tanaka, T., Ogino, C., Kondo, A., Okamoto, M. & Hanai, T., 7 1 2012, : : Journal of Bioscience and Bioengineering. 114, 1, p. 80-85 6 p.

研究成果: ジャーナルへの寄稿記事

Cellobiose
2-Propanol
Escherichia coli
Display devices
beta-Glucosidase
2011
1 引用 (Scopus)

Development of an analytical pipeline for optimizing substrate feeding and eliminating metabolic bottlenecks

Kuriya, Y., Tanaka, S., Kobayashi, G., Hanai, T. & Okamoto, M., 1 1 2011, : : Chem-Bio Informatics Journal. 11, 1, p. 1-23 23 p.

研究成果: ジャーナルへの寄稿記事

Butanols
Pipelines
Clostridium
Biofuels
Substrates
2010
18 引用 (Scopus)

An agar gel membrane-PDMS hybrid microfluidic device for long term single cell dynamic study

Wong, I., Atsumi, S., Huang, W. C., Wu, T. Y., Hanai, T., Lam, M. L., Tang, P., Yang, J., Liao, J. C. & Ho, C. M., 10 21 2010, : : Lab on a Chip. 10, 20, p. 2710-2719 10 p.

研究成果: ジャーナルへの寄稿記事

Lab-On-A-Chip Devices
Microfluidics
Agar
Gels
Membranes
100 引用 (Scopus)

Improvement of isopropanol production by metabolically engineered Escherichia coli using gas stripping

Inokuma, K., Liao, J. C., Okamoto, M. & Hanai, T., 12 1 2010, : : Journal of Bioscience and Bioengineering. 110, 6, p. 696-701 6 p.

研究成果: ジャーナルへの寄稿記事

2-Propanol
Escherichia coli
Gases
Glucose
Batch Cell Culture Techniques
2009
19 引用 (Scopus)

Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics

Hamada, H., Tashima, Y., Kisaka, Y., Iwamoto, K., Hanai, T., Eguchi, Y. & Okamoto, M., 3 10 2009, : : PloS one. 4, 3, e4795.

研究成果: ジャーナルへの寄稿記事

Cell Cycle Checkpoints
apoptosis
Cells
Apoptosis
DNA damage
2008
52 引用 (Scopus)

Kinetic study of substrate dependency for higher butanol production in acetone-butanol-ethanol fermentation

Shinto, H., Tashiro, Y., Kobayashi, G., Sekiguchi, T., Hanai, T., Kuriya, Y., Okamoto, M. & Sonomoto, K., 12 1 2008, : : Process Biochemistry. 43, 12, p. 1452-1461 10 p.

研究成果: ジャーナルへの寄稿記事

Butanols
Xylose
Acetone
Butenes
Fermentation
561 引用 (Scopus)

Metabolic engineering of Escherichia coli for 1-butanol production

Atsumi, S., Cann, A. F., Connor, M. R., Shen, C. R., Smith, K. M., Brynildsen, M. P., Chou, K. J. Y., Hanai, T. & Liao, J. C., 11 1 2008, : : Metabolic Engineering. 10, 6, p. 305-311 7 p.

研究成果: ジャーナルへの寄稿記事

Metabolic engineering
Metabolic Engineering
1-Butanol
Butenes
Escherichia coli
16 引用 (Scopus)

Modified Fuzzy Gap statistic for estimating preferable number of clusters in Fuzzy k-means clustering

Arima, C., Hakamada, K., Okamoto, M. & Hanai, T., 3 1 2008, : : Journal of Bioscience and Bioengineering. 105, 3, p. 273-281 9 p.

研究成果: ジャーナルへの寄稿記事

Cluster Analysis
Statistics
Noise
Microarrays
Gene expression
1201 引用 (Scopus)

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

Atsumi, S., Hanai, T. & Liao, J. C., 1 3 2008, : : Nature. 451, 7174, p. 86-89 4 p.

研究成果: ジャーナルへの寄稿記事

Biofuels
Alcohols
1-Butanol
Phenylethyl Alcohol
Wettability
11 引用 (Scopus)

Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis

Tashima, Y., Hamada, H., Okamoto, M. & Hanai, T., 10 1 2008, : : Journal of Bioscience and Bioengineering. 106, 4, p. 368-374 7 p.

研究成果: ジャーナルへの寄稿記事

Phase Transition
G1 Phase
Systems Analysis
S Phase
Cell Cycle
2007
8 引用 (Scopus)

A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease

Utsunomiya, T., Okamoto, M., Wakiyama, S., Hashimoto, M., Fukuzawa, K., Ezaki, T., Aishima, S., Yoshikawa, Y., Hanai, T., Inoue, H., Barnard, G. F. & Mori, M., 1 21 2007, : : World Journal of Gastroenterology. 13, 3, p. 383-390 8 p.

研究成果: ジャーナルへの寄稿記事

Transcriptome
Liver Cirrhosis
Liver Diseases
Fibrosis
Chronic Disease
189 引用 (Scopus)

Engineered synthetic pathway for isopropanol production in Escherichia coli

Hanai, T., Atsumi, S. & Liao, J. C., 12 1 2007, : : Applied and environmental microbiology. 73, 24, p. 7814-7818 5 p.

研究成果: ジャーナルへの寄稿記事

2-Propanol
isopropyl alcohol
Clostridium beijerinckii
alcohol
Escherichia coli
78 引用 (Scopus)

Kinetic modeling and sensitivity analysis of acetone-butanol-ethanol production

Shinto, H., Tashiro, Y., Yamashita, M., Kobayashi, G., Sekiguchi, T., Hanai, T., Kuriya, Y., Okamoto, M. & Sonomoto, K., 8 1 2007, : : Journal of Biotechnology. 131, 1, p. 45-56 12 p.

研究成果: ジャーナルへの寄稿記事

Butanols
Acetone
Butenes
Sensitivity analysis
Metabolites
25 引用 (Scopus)

Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition

Shikata, N., Maki, Y., Noguchi, Y., Mori, M., Hanai, T., Takahashi, M. & Okamoto, M., 7 1 2007, : : Amino Acids. 33, 1, p. 113-121 9 p.

研究成果: ジャーナルへの寄稿記事

Essential Amino Acids
Metabolism
Plasmas
Amino Acids
Threonine
3 引用 (Scopus)

TIMP-3 and Phosphatidylinositol 3-kinase genes were found to be related to the progression of colon cancer in a comparison of pneumoperitoneum and laparotomy in a murine model

Tanaka, F., Sonoda, H., Okamoto, M., Mimori, K., Utsunomiya, T., Inoue, H., Hanai, T. & Mori, M., 3 1 2007, : : Surgery Today. 37, 3, p. 220-225 6 p.

研究成果: ジャーナルへの寄稿記事

Tissue Inhibitor of Metalloproteinase-3
Phosphatidylinositol 3-Kinase
Pneumoperitoneum
Phosphatidylinositol 3-Kinases
Colonic Neoplasms
2006
23 引用 (Scopus)

Application of bioinformatics for DNA microarray data to bioscience, bioengineering and medical fields

Hanai, T., Hamada, H. & Okamoto, M., 5 1 2006, : : Journal of Bioscience and Bioengineering. 101, 5, p. 377-384 8 p.

研究成果: ジャーナルへの寄稿記事

Bioengineering
Biomedical engineering
Bioinformatics
Microarrays
Oligonucleotide Array Sequence Analysis
15 引用 (Scopus)
Model-based Clustering
DNA Microarray
Microarrays
Oligonucleotide Array Sequence Analysis
Cluster Analysis
15 引用 (Scopus)

Novel technique for preprocessing high dimensional time-course data from DNA microarray: Mathematical model-based clustering

Hakamada, K., Okamoto, M. & Hanai, T., 4 1 2006, : : Bioinformatics. 22, 7, p. 843-848 6 p.

研究成果: ジャーナルへの寄稿記事

Model-based Clustering
DNA Microarray
Microarrays
Oligonucleotide Array Sequence Analysis
Cluster Analysis
63 引用 (Scopus)

Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients

Okamoto, M., Utsunomiya, T., Wakiyama, S., Hashimoto, M., Fukuzawa, K., Ezaki, T., Hanai, T., Inoue, H. & Mori, M., 7 1 2006, : : Annals of Surgical Oncology. 13, 7, p. 947-954 8 p.

研究成果: ジャーナルへの寄稿記事

Transcriptome
Hepacivirus
Hepatocellular Carcinoma
Liver
Recurrence
2005
37 引用 (Scopus)

Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: A study combined with a laser microdissection and a cDNA microarray

Nishida, K., Mine, S., Utsunomiya, T., Inoue, H., Okamoto, M., Udagawa, H., Hanai, T. & Mori, M., 1 15 2005, : : Cancer Research. 65, 2, p. 401-409 9 p.

研究成果: ジャーナルへの寄稿記事

Microdissection
Oligonucleotide Array Sequence Analysis
Carcinogenesis
Lasers
Epithelial Cells
2004
10 引用 (Scopus)

A preprocessing method for inferring genetic interaction from gene expression data using Boolean algorithm

Hakamada, K., Hanai, T., Honda, H. & Kobayashi, T., 1 1 2004, : : Journal of Bioscience and Bioengineering. 98, 6, p. 457-463 7 p.

研究成果: ジャーナルへの寄稿記事

Gene expression
Genes
Gene Expression
Encyclopedias
Genome

Evaluation of the Alzheimer-type dementia by magnetic resonance imaging using fuzzy neural networks

Liu, X., Hibino, S., Hasegawa, Y., Hanai, T., Mitsushima, T., Iida, A., Matsubara, M., Honda, H. & Kobayashi, T., 3 1 2004, : : JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 37, 3, p. 429-435 7 p.

研究成果: ジャーナルへの寄稿記事

Fuzzy neural networks
Magnetic resonance
Imaging techniques
Magnetic resonance imaging
Brain
6 引用 (Scopus)

Proposal of reliability index in search for reliable solutions of reverse calculation based on fuzzy neural network modeling

Hanai, T., Iwata, N., Furuhashi, T., Honda, H. & Kobayashi, T., 4 2004, : : Journal of Chemical Engineering of Japan. 37, 4, p. 523-530 8 p.

研究成果: ジャーナルへの寄稿記事

Fuzzy neural networks
Error analysis
Genetic algorithms
Neural networks
2003
18 引用 (Scopus)

Analysis of initial conditions for polymerization reaction using fuzzy neural network and genetic algorithm

Hanai, T., Ohki, T., Honda, H. & Kobayashi, T., 7 15 2003, : : Computers and Chemical Engineering. 27, 7, p. 1011-1019 9 p.

研究成果: ジャーナルへの寄稿記事

Fuzzy neural networks
Genetic algorithms
Polymerization
Polymers
Polydispersity
25 引用 (Scopus)

Analysis of organic solvent tolerance in Escherichia coli using gene expression profiles from DNA microarrays

Hayashi, S., Aono, R., Hanai, T., Mori, H., Kobayashi, T. & Honda, H., 1 1 2003, : : Journal of Bioscience and Bioengineering. 95, 4, p. 379-383 5 p.

研究成果: ジャーナルへの寄稿記事

Microarrays
Oligonucleotide Array Sequence Analysis
Transcriptome
Gene expression
Organic solvents
3 引用 (Scopus)

Construction of an Electroencephalogram-Based Brain-Computer Interface Using an Artificial Neural Network

Liu, X., Hibino, S., Hanai, T., Imanishi, T., Shirataki, T., Ogawa, T., Honda, H. & Kobayashi, T., 1 1 2003, : : IEICE Transactions on Information and Systems. E86-D, 9, p. 1879-1886 8 p.

研究成果: ジャーナルへの寄稿記事

Brain computer interface
Electroencephalography
Neural networks
Power spectrum
Control systems
14 引用 (Scopus)

Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression

Hanai, T., Yatabe, Y., Nakayama, Y., Takahashi, T., Honda, H., Mitsudomi, T. & Kobayashi, T., 5 1 2003, : : Cancer Science. 94, 5, p. 473-477 5 p.

研究成果: ジャーナルへの寄稿記事

Non-Small Cell Lung Carcinoma
Logistic Models
Survival
Neural Networks (Computer)
Cyclin D1
2002
53 引用 (Scopus)

Analysis of expression profile using fuzzy adaptive resonance theory

Tomida, S., Hanai, T., Honda, H. & Kobayashi, T., 1 1 2002, : : Bioinformatics. 18, 8, p. 1073-1083 11 p.

研究成果: ジャーナルへの寄稿記事

Adaptive Resonance Theory
Fuzzy Theory
Cluster Analysis
Clustering
Clustering Methods
22 引用 (Scopus)

Artificial neural network predictive model for allergic disease using single nucleotide polymorphisms data

Tomida, S., Hanai, T., Koma, N., Suzuki, Y., Kobayashi, T. & Honda, H., 1 1 2002, : : Journal of Bioscience and Bioengineering. 93, 5, p. 470-478 9 p.

研究成果: ジャーナルへの寄稿記事

Neural Networks (Computer)
Nucleotides
Polymorphism
Single Nucleotide Polymorphism
Neural networks
6 引用 (Scopus)

Determination of the blending ratio of regular coffee samples by information technology

Tominaga, O., Ito, F., Hanai, T., Honda, H. & Kobayashi, T., 2 1 2002, : : Journal of Chemical Engineering of Japan. 35, 2, p. 137-143 7 p.

研究成果: ジャーナルへの寄稿記事

Coffee
Information technology
Fuzzy neural networks
Genetic algorithms
Flavors
43 引用 (Scopus)

Fuzzy neural network applied to gene expression profiling for predicting the prognosis of diffuse large B-cell Lymphoma

Ando, T., Suguro, M., Hanai, T., Kobayashi, T., Honda, H. & Seto, M., 11 1 2002, : : Japanese Journal of Cancer Research. 93, 11, p. 1207-1212 6 p.

研究成果: ジャーナルへの寄稿記事

Lymphoma, Large B-Cell, Diffuse
Gene Expression Profiling
Neural Networks (Computer)
Combination Drug Therapy
Genes