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研究成果 2003 2019

  • 1478 引用
  • 17 h指数
  • 37 記事
  • 7 評論記事
  • 1 レター
2019
4 引用 (Scopus)

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer

Hirota, T., Muraki, S. & Ieiri, I., 4 4 2019, : : Clinical Pharmacokinetics. 58, 4, p. 403-420 18 p.

研究成果: ジャーナルへの寄稿評論記事

Non-Small Cell Lung Carcinoma
Pharmacokinetics
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
3 引用 (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., 2 1 2019, : : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

研究成果: ジャーナルへの寄稿記事

Sulfates
Healthy Volunteers
Genotype
fluvastatin
Pharmaceutical Preparations

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., 3 6 2019, : : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

研究成果: ジャーナルへの寄稿記事

Magnesium Oxide
Carbidopa
Levodopa
Pharmacokinetics
Meta-Analysis
3 引用 (Scopus)

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., 2 1 2019, : : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

研究成果: ジャーナルへの寄稿記事

Glucagon-Like Peptide 1
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Meta-Analysis
3 引用 (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., 2 2019, : : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

研究成果: ジャーナルへの寄稿記事

oxaliplatin
Peripheral Nervous System Diseases
Spinal Ganglia
Platinum
Pharmaceutical Preparations

Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients

Higuchi, K., Yamashita, D., Kashihara, Y., Kakara, M., Hirota, T., Hirakawa, M. & Ieiri, I., 10 1 2019, : : Therapeutic drug monitoring. 41, 5, p. 674-680 7 p.

研究成果: ジャーナルへの寄稿記事

Phenytoin
Intravenous Administration
Pharmacokinetics
Population
Body Weight
2018
1 引用 (Scopus)

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models

Tamaki, Y., Maema, K., Kakara, M., Fukae, M., Kinoshita, R., Kashihara, Y., Muraki, S., Hirota, T. & Ieiri, I., 12 1 2018, : : Drug metabolism and pharmacokinetics. 33, 6, p. 264-269 6 p.

研究成果: ジャーナルへの寄稿記事

Metformin
Population
Therapeutics
Electronic Health Records
Glycosylated Hemoglobin A

Epigenetic regulation of pharmacokinetic-related genes in human tissues

Hirota, T., 1 1 2018, : : Yakugaku Zasshi. 138, 11, p. 1391-1396 6 p.

研究成果: ジャーナルへの寄稿評論記事

Epigenomics
Pharmacokinetics
Breast Neoplasms
Pharmaceutical Preparations
Genes
4 引用 (Scopus)
CpG Islands
Human Activities
Methylation
Skin
Messenger RNA
2 引用 (Scopus)

Nucleosome positioning and gene regulation of the SGLT2 gene in the renal proximal tubular epithelial cells

Takesue, H., Hirota, T., Tachimura, M., Tokashiki, A. & Ieiri, I., 9 1 2018, : : Molecular Pharmacology. 94, 3, p. 953-962 10 p.

研究成果: ジャーナルへの寄稿記事

Sodium-Glucose Transport Proteins
Nucleosomes
Epithelial Cells
Kidney
Genes

Population Pharmacodynamic Analysis of Uric Acid–Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals

Muraki, S., Moriki, K., Shigematsu, S., Fukae, M., Kakara, M., Yamashita, D., Hirota, T., Takane, H., Shimada, M., Hirakawa, M. & Ieiri, I., 3 1 2018, : : Journal of Clinical Pharmacology. 58, 3, p. 304-313 10 p.

研究成果: ジャーナルへの寄稿記事

Electronic Health Records
Uric Acid
Population
Blood Urea Nitrogen
Urban Hospitals
2 引用 (Scopus)
CpG Islands
DNA Methylation
Liver
Proteins
Messenger RNA
2017
4 引用 (Scopus)

Epigenetic regulation of drug transporter expression in human tissues

Hirota, T., Tanaka, T., Takesue, H. & Ieiri, I., 1 2 2017, : : Expert Opinion on Drug Metabolism and Toxicology. 13, 1, p. 19-30 12 p.

研究成果: ジャーナルへの寄稿評論記事

Drug and Narcotic Control
Epigenomics
Tissue
Pharmaceutical Preparations
Genes
18 引用 (Scopus)

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP

Kashihara, Y., Ieiri, I., Yoshikado, T., Maeda, K., Fukae, M., Kimura, M., Hirota, T., Matsuki, S., Irie, S., Izumi, N., Kusuhara, H. & Sugiyama, Y., 9 1 2017, : : Journal of Pharmaceutical Sciences. 106, 9, p. 2688-2694 7 p.

研究成果: ジャーナルへの寄稿記事

Citrus paradisi
Pharmacogenetics
Pharmacokinetics
Sulfasalazine
Pharmaceutical Preparations
2016
9 引用 (Scopus)

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

Gotanda, K., Hirota, T., Saito, J., Fukae, M., Egashira, Y., Izumi, N., Deguchi, M., Kimura, M., Matsuki, S., Irie, S. & Ieiri, I., 8 30 2016, : : Scientific reports. 6, 32299.

研究成果: ジャーナルへの寄稿記事

Intestines
Biomarkers
Breast Neoplasms
Proteins
Area Under Curve
1 引用 (Scopus)

Population pharmacodynamic analysis of hemoglobin A1c-lowering effects by adding treatment of DPP-4 inhibitors (sitagliptin) in type 2 diabetes mellitus patients based on electronic medical records

Kakara, M., Nomura, H., Ezaki, M., Fukae, M., Hirota, T., Matsubayashi, S., Hirakawa, M. & Ieiri, I., 9 1 2016, : : Journal of Diabetes and Its Complications. 30, 7, p. 1282-1286 5 p.

研究成果: ジャーナルへの寄稿記事

Electronic Health Records
pioglitazone
Type 2 Diabetes Mellitus
Hemoglobins
Population
8 引用 (Scopus)

Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer

Fukae, M., Shiraishi, Y., Hirota, T., Sasaki, Y., Yamahashi, M., Takayama, K., Nakanishi, Y. & Ieiri, I., 11 1 2016, : : Cancer chemotherapy and pharmacology. 78, 5, p. 1013-1023 11 p.

研究成果: ジャーナルへの寄稿記事

docetaxel
Neutropenia
Non-Small Cell Lung Carcinoma
Cells
Population
2015
30 引用 (Scopus)

Drug-drug interactions that interfere with statin metabolism

Hirota, T. & Ieiri, I., 9 2 2015, : : Expert Opinion on Drug Metabolism and Toxicology. 11, 9, p. 1435-1447 13 p.

研究成果: ジャーナルへの寄稿評論記事

Drug interactions
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug Interactions
Metabolism
Pharmaceutical Preparations
8 引用 (Scopus)

Sulfasalazine disposition in a subject with 376C>T (nonsense mutation) and 421C>A variants in the ABCG2 gene

Gotanda, K., Tokumoto, T., Hirota, T., Fukae, M. & Ieiri, I., 11 1 2015, : : British journal of clinical pharmacology. 80, 5, p. 1236-1237 2 p.

研究成果: ジャーナルへの寄稿レター

Neoplasm Proteins
Sulfasalazine
ATP-Binding Cassette Transporters
Nonsense Codon
Genetic Polymorphisms
2014
8 引用 (Scopus)

Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K

Nishimura, K., Ide, R., Hirota, T., Kawazu, K., Kodama, S., Takesue, H. & Ieiri, I., 1 1 2014, : : Drug Metabolism and Disposition. 42, 9, p. 1432-1437 6 p.

研究成果: ジャーナルへの寄稿記事

Single Nucleotide Polymorphism
Cations
Cell Membrane
Antiporters
Tetraethylammonium
10 引用 (Scopus)

Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: A DMET Plus microarray assessment

Yi, S., An, H., Lee, H., Lee, S., Ieiri, I., Lee, Y., Cho, J. Y., Hirota, T., Fukae, M., Yoshida, K., Nagatsuka, S., Kimura, M., Irie, S., Sugiyama, Y., Shin, D. W., Lim, K. S., Chung, J. Y., Yu, K. S. & Jang, I. J., 10 10 2014, : : Pharmacogenetics and Genomics. 24, 10, p. 477-485 9 p.

研究成果: ジャーナルへの寄稿記事

Ethnic Groups
Enzymes
Principal Component Analysis
Pharmaceutical Preparations
Population
6 引用 (Scopus)

Neonatal Dubin-Johnson syndrome: Novel compound heterozygous mutation in the ABCC2 gene

Okada, H., Kusaka, T., Fuke, N., Kunikata, J., Kondo, S., Iwase, T., Nan, W., Hirota, T., Ieiri, I. & Itoh, S., 10 1 2014, : : Pediatrics International. 56, 5, p. e62-e64

研究成果: ジャーナルへの寄稿記事

Chronic Idiopathic Jaundice
Bilirubin
Mutation
Missense Mutation
Genes
6 引用 (Scopus)

Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records

Kakara, M., Nomura, H., Fukae, M., Gotanda, K., Hirota, T., Matsubayashi, S., Shimomura, H., Hirakawa, M. & Ieiri, I., 10 1 2014, : : British journal of clinical pharmacology. 78, 4, p. 824-835 12 p.

研究成果: ジャーナルへの寄稿記事

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Electronic Health Records
LDL Cholesterol
Population
Anticholesteremic Agents
2013
17 引用 (Scopus)
5' Flanking Region
DNA methylation
DNA Methylation
placenta
Individuality
63 引用 (Scopus)

Impact of genetic polymorphisms in CYP2C9 and CYP2C19 on the pharmacokinetics of clinically used drugs

Hirota, T., Eguchi, S. & Ieiri, I., 1 1 2013, : : Drug Metabolism and Pharmacokinetics. 28, 1, p. 28-37 10 p.

研究成果: ジャーナルへの寄稿評論記事

Genetic Polymorphisms
Pharmacokinetics
Pharmaceutical Preparations
Precision Medicine
Xenobiotics
24 引用 (Scopus)

Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-Glycoprotein), and pravastatin (OATP1B1) as probe drugs

Ieiri, I., Tsunemitsu, S., Maeda, K., Ando, Y., Izumi, N., Kimura, M., Yamane, N., Okuzono, T., Morishita, M., Kotani, N., Kanda, E., Deguchi, M., Matsuguma, K., Matsuki, S., Hirota, T., Irie, S., Kusuhara, H. & Sugiyama, Y., 6 1 2013, : : Journal of Clinical Pharmacology. 53, 6, p. 654-661 8 p.

研究成果: ジャーナルへの寄稿記事

fexofenadine
Saquinavir
Cytochrome P-450 CYP3A
Pravastatin
Ritonavir
36 引用 (Scopus)
Thymidylate Synthase
MicroRNAs
HeLa Cells
Fluorouracil
Messenger RNA
10 引用 (Scopus)

Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes

Ando, Y., Shimada, H., Matsumoto, N., Hirota, T., Oribe, M., Otsuka, E., Ishii, K., Morimoto, T., Ohashi, K. & Ieiri, I., 1 1 2013, : : Drug metabolism and pharmacokinetics. 28, 5, p. 442-445 4 p.

研究成果: ジャーナルへの寄稿記事

Reduced Folate Carrier Protein
Methotrexate
Genes
Erythrocytes
2012
39 引用 (Scopus)

Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues

Hirota, T., Date, Y., Nishibatake, Y., Takane, H., Fukuoka, Y., Taniguchi, Y., Burioka, N., Shimizu, E., Nakamura, H., Otsubo, K. & Ieiri, I., 7 1 2012, : : Lung Cancer. 77, 1, p. 16-23 8 p.

研究成果: ジャーナルへの寄稿記事

Dihydrouracil Dehydrogenase (NADP)
MicroRNAs
Lung
Fluorouracil
Neoplasms
65 引用 (Scopus)

Microdosing clinical study: Pharmacokinetic, pharmacogenomic (SLCO2B1), and interaction (grapefruit juice) profiles of celiprolol following the oral microdose and therapeutic dose

Ieiri, I., Doi, Y., Maeda, K., Sasaki, T., Kimura, M., Hirota, T., Chiyoda, T., Miyagawa, M., Irie, S., Iwasaki, K. & Sugiyama, Y., 7 1 2012, : : Journal of Clinical Pharmacology. 52, 7, p. 1078-1089 12 p.

研究成果: ジャーナルへの寄稿記事

Celiprolol
Citrus paradisi
Pharmacogenetics
Pharmacokinetics
fexofenadine
14 引用 (Scopus)

Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing

Ieiri, I., Fukae, M., Maeda, K., Ando, Y., Kimura, M., Hirota, T., Nakamura, T., Iwasaki, K., Matsuki, S., Matsuguma, K., Kanda, E., Deguchi, M., Irie, S. & Sugiyama, Y., 10 1 2012, : : International Journal of Clinical Pharmacology and Therapeutics. 50, 10, p. 689-700 12 p.

研究成果: ジャーナルへの寄稿記事

Pharmacogenetics
Lansoprazole
Pharmacokinetics
Genotype
Glyburide
2011
17 引用 (Scopus)
Nucleic Acid Regulatory Sequences
Epigenomics
DNA Methylation
Acetylation
Histones
39 引用 (Scopus)

Pharmacokinetic and pharmacogenomic profiles of telmisartan after the oral microdose and therapeutic dose

Ieiri, I., Nishimura, C., Maeda, K., Sasaki, T., Kimura, M., Chiyoda, T., Hirota, T., Irie, S., Shimizu, H., Noguchi, T., Yoshida, K. & Sugiyama, Y., 8 1 2011, : : Pharmacogenetics and Genomics. 21, 8, p. 495-505 11 p.

研究成果: ジャーナルへの寄稿記事

Pharmacogenetics
Pharmacokinetics
Linkage Disequilibrium
Haplotypes
Therapeutics
58 引用 (Scopus)

Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients

Sasaki, T., Takane, H., Ogawa, K., Isagawa, S., Hirota, T., Higuchi, S., Horii, T., Otsubo, K. & Ieiri, I., 5 1 2011, : : Antimicrobial Agents and Chemotherapy. 55, 5, p. 1867-1873 7 p.

研究成果: ジャーナルへの寄稿記事

Linezolid
Thrombocytopenia
Pharmacokinetics
Platelet Count
Population
10 引用 (Scopus)

Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function

Sasaki, T., Hirota, T., Ryokai, Y., Kobayashi, D., Kimura, M., Irie, S., Higuchi, S. & Ieiri, I., 1 1 2011, : : Drug metabolism and pharmacokinetics. 26, 4, p. 374-386 13 p.

研究成果: ジャーナルへの寄稿記事

Hymecromone
Glucuronides
Genetic Polymorphisms
Reporter Genes
Pharmacokinetics
2009
11 引用 (Scopus)

Novel large-scale deletion (whole Exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome

Kanda, D., Takagi, H., Kawahara, Y., Yata, Y., Takakusagi, T., Hatanaka, T., Yoshinaga, T., Iesaki, K., Kashiwabara, K., Higuchi, T., Mori, M., Hirota, T., Higuchi, S. & Ieiri, I., 1 1 2009, : : Drug Metabolism and Pharmacokinetics. 24, 5, p. 464-468 5 p.

研究成果: ジャーナルへの寄稿記事

Chronic Idiopathic Jaundice
Constrictive Pericarditis
Exons
Hyperbilirubinemia
Genes
2008
22 引用 (Scopus)

Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms

Hirota, T., Takane, H., Higuchi, S. & Ieiri, I., 1 1 2008, : : Current Drug Metabolism. 9, 1, p. 34-38 5 p.

研究成果: ジャーナルへの寄稿評論記事

Gene encoding
DNA Methylation
Epigenomics
Genes
Pharmacodynamics
1 引用 (Scopus)

Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans

Ieiri, I., Yamasaki, Y., Sasaki, T., Hirota, T., Higuchi, S., Kimura, M., Irie, S., Kusuhara, H. & Sugiyama, Y., 12 1 2008, : : Japanese Pharmacology and Therapeutics. 36, SUPPL. 2, p. 131-134 4 p.

研究成果: ジャーナルへの寄稿記事

Sulfasalazine
Pharmacogenetics
Genes
29 引用 (Scopus)

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism

Suwannakul, S., Ieiri, I., Kimura, M., Kawabata, K., Kusuhara, H., Hirota, T., Irie, S., Sugiyama, Y. & Higuchi, S., 10 1 2008, : : Journal of Human Genetics. 53, 10, p. 899-904 6 p.

研究成果: ジャーナルへの寄稿記事

Pravastatin
Pharmacokinetics
Sample Size
olmesartan
Healthy Volunteers
2006
40 引用 (Scopus)

Genetic polymorphisms of drug transporters: Pharmacokinetic and pharmacodynamic consequences in pharmacotherapy

Ieiri, I., Takane, H., Hirota, T., Otsubo, K. & Higuchi, S., 12 1 2006, : : Expert Opinion on Drug Metabolism and Toxicology. 2, 5, p. 651-674 24 p.

研究成果: ジャーナルへの寄稿評論記事

Pharmacodynamics
Drug therapy
Pharmacokinetics
Genetic Polymorphisms
Polymorphism
2005
227 引用 (Scopus)

Functional assessment of ABCG2 (BRCP) gene polymorphisms to protein expression in human placenta

Kobayashi, D., Ieiri, I., Hirota, T., Takane, H., Maegawa, S., Kigawa, J., Suzuki, H., Nanba, E., Oshimura, M., Terakawa, N., Otsubo, K., Mine, K. & Sugiyama, Y., 1 1 2005, : : Drug Metabolism and Disposition. 33, 1, p. 94-101 8 p.

研究成果: ジャーナルへの寄稿記事

Placenta
Alleles
Allelic Imbalance
Terminator Codon
Genes
2004
43 引用 (Scopus)

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status

Hirota, T., Ieire, I., Takane, H., Maegawa, S., Hosokawa, M., Kobayashi, K., Chiba, K., Nanba, E., Oshimura, M., Sato, T., Higuchi, S. & Kenji, O., 12 1 2004, : : Human Molecular Genetics. 13, 23, p. 2959-2969 11 p.

研究成果: ジャーナルへの寄稿記事

Allelic Imbalance
Cytochrome P-450 CYP3A
Genes
Messenger RNA
Alleles
74 引用 (Scopus)

Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene

Takane, H., Kobayashi, D., Hirota, T., Kigawa, J., Terakawa, N., Otsubo, K. & Ieiri, I., 12 1 2004, : : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 1179-1187 9 p.

研究成果: ジャーナルへの寄稿記事

Genetic Promoter Regions
Haplotypes
Genes
Nucleotides
Multiple Drug Resistance
2003
430 引用 (Scopus)

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Nishizato, Y., Ieiri, I., Suzuki, H., Kimura, M., Kawabata, K., Hirota, T., Takane, H., Irie, S., Kusuhara, H., Urasaki, Y., Urae, A., Higuchi, S., Otsubo, K. & Sugiyama, Y., 6 1 2003, : : Clinical Pharmacology and Therapeutics. 73, 6, p. 554-565 12 p.

研究成果: ジャーナルへの寄稿記事

Organic Anion Transporters
Pravastatin
Anions
Pharmacokinetics
Genes
79 引用 (Scopus)

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy

Hirota, T., Ieiri, I., Takane, H., Sano, H., Kawamoto, K., Aono, H., Yamasaki, A., Takeuchi, H., Masada, M., Shimizu, E., Higuchi, S. & Otsubo, K., 5 1 2003, : : Drug Metabolism and Disposition. 31, 5, p. 677-680 4 p.

研究成果: ジャーナルへの寄稿記事

Genetic Association Studies
Morphine
Glucuronosyltransferase
Single Nucleotide Polymorphism
Neoplasms