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研究成果 2000 2019

  • 1520 引用
  • 18 h指数
  • 33 記事
2019

Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α

Higuchi, Y., Niidome, T., Miyamoto, Y., Komohara, Y., Tokunou, T., Kubota, T. & Horiuchi, T., 3 15 2019, : : Heart and Vessels. 34, 3, p. 538-544 7 p.

研究成果: ジャーナルへの寄稿記事

Gold
Transgenic Mice
Nanoparticles
Hypertrophy
Weights and Measures

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., 4 2019, : : Physiological Reports. 7, 7, e14025.

研究成果: ジャーナルへの寄稿記事

公開
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Knockout Mice
Lung
Macrophages
2018

Cardiac sarcoidosis concomitant with large-vessel aortitis detected by 18F-fluorodeoxyglucose positron emission tomography

Higuchi, Y., Kimoto, Y., Tanoue, R., Tokunou, T., Tomonari, K., Maeda, T. & Horiuchi, T., 1 1 2018, : : Internal Medicine. 57, 11, p. 1601-1604 4 p.

研究成果: ジャーナルへの寄稿記事

Aortitis
Fluorodeoxyglucose F18
Sarcoidosis
Positron-Emission Tomography
Immunosuppressive Agents
1 引用 (Scopus)

Suppression of abdominal aortic aneurysm formation in mice by teneligliptin, a dipeptidyl peptidase-4 inhibitor

Takahara, Y., Tokunou, T. & Ichiki, T., 1 1 2018, : : Journal of atherosclerosis and thrombosis. 25, 8, p. 698-708 11 p.

研究成果: ジャーナルへの寄稿記事

Dipeptidyl-Peptidase IV Inhibitors
Abdominal Aortic Aneurysm
Angiotensins
Apolipoproteins E
Knockout Mice
2017
6 引用 (Scopus)

Deletion of hypoxia-inducible factor-1a in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm

Takahara, Y., Tokunou, T., Kojima, H., Hirooka, Y. & Ichiki, T., 4 1 2017, : : Clinical Science. 131, 7, p. 609-620 12 p.

研究成果: ジャーナルへの寄稿記事

Abdominal Aortic Aneurysm
Angiotensin II
High Fat Diet
Apolipoproteins E
Hypoxia
2016
10 引用 (Scopus)

Cumulative hypoxemia during sleep predicts vascular endothelial dysfunction in patients with sleep-disordered breathing

Sawatari, H., Chishaki, A., Nishizaka, M., Tokunou, T., Adachi, S., Yoshimura, C., Ohkusa, T. & Ando, S. I., 1 1 2016, : : American Journal of Hypertension. 29, 4, p. 458-463 6 p.

研究成果: ジャーナルへの寄稿記事

Sleep Apnea Syndromes
Blood Vessels
Sleep
Oxygen
Apnea
6 引用 (Scopus)

Suppression of abdominal aortic aneurysm formation by AR-R17779, an agonist for the α7 nicotinic acetylcholine receptor

Watanabe, A., Ichiki, T., Kojima, H., Takahara, Y., Hurt-Camejo, E., Michaëlsson, E., Sankoda, C., Ikeda, J., Inoue, E., Tokunou, T., Kitamoto, S. & Sunagawa, K., 1 1 2016, : : Atherosclerosis. 244, p. 113-120 8 p.

研究成果: ジャーナルへの寄稿記事

Abdominal Aortic Aneurysm
Nicotinic Receptors
Abdominal Aorta
Matrix Metalloproteinases
AR-R 17779
2015
20 引用 (Scopus)

PPARγ agonists attenuate palmitate-induced ER stress through up-regulation of SCD-1 in macrophages

Ikeda, J., Ichiki, T., Takahara, Y., Kojima, H., Sankoda, C., Kitamoto, S., Tokunou, T. & Sunagawa, K., 6 10 2015, : : PloS one. 10, 6, e0128546.

研究成果: ジャーナルへの寄稿記事

pioglitazone
Peroxisome Proliferator-Activated Receptors
Endoplasmic Reticulum Stress
Macrophages
Palmitates
2014
18 引用 (Scopus)

Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice

Hashimoto, T., Ichiki, T., Watanabe, A., Hurt-Camejo, E., Michaëlsson, E., Ikeda, J., Inoue, E., Matsuura, H., Tokunou, T., Kitamoto, S. & Sunagawa, K., 5 2014, : : Vascular Pharmacology. 61, 2-3, p. 49-55 7 p.

研究成果: ジャーナルへの寄稿記事

Aortic Aneurysm
Nicotinic Receptors
Apolipoproteins E
Atherosclerosis
High Fat Diet
23 引用 (Scopus)

Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption

Watanabe, A., Ichiki, T., Sankoda, C., Takahara, Y., Ikeda, J., Inoue, E., Tokunou, T., Kitamoto, S. & Sunagawa, K., 5 1 2014, : : Clinical Science. 126, 9, p. 671-678 8 p.

研究成果: ジャーナルへの寄稿記事

Prolyl Hydroxylases
Abdominal Aortic Aneurysm
Extracellular Matrix
Inflammation
Matrix Metalloproteinases
2013

Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling

Ikeda, J., Ichiki, T., Matsuura, H., Inoue, E., Kishimoto, J., Watanabe, A., Sankoda, C., Kitamoto, S., Tokunou, T., Takeda, K., Fong, G. H. & Sunagawa, K., 6 1 2013, : : Journal of the American Heart Association. 2, 3, p. e000178

研究成果: ジャーナルへの寄稿記事

NG-Nitroarginine Methyl Ester
Angiotensin II
Macrophages
Fibrosis
Hypertrophy
19 引用 (Scopus)

Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling

Ikeda, J., Ichiki, T., Matsuura, H., Inoue Eriko, E., Kishimoto, J., Watanabe, A., Sankoda, C., Kitamoto, S., Tokunou, T., Takeda, K., Fong, G. H. & Sunagawa, K., 9 4 2013, : : Journal of the American Heart Association. 2, 3, e000178.

研究成果: ジャーナルへの寄稿記事

公開
NG-Nitroarginine Methyl Ester
Angiotensin II
Macrophages
Fibrosis
Hypertrophy

Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.

Ikeda, J., Ichiki, T., Matsuura, H., Inoue, E., Kishimoto, J., Watanabe, A., Sankoda, C., Kitamoto, S., Tokunou, T., Takeda, K., Fong, G. H. & Sunagawa, K., 6 1 2013, : : Journal of the American Heart Association. 2, 3

研究成果: ジャーナルへの寄稿記事

NG-Nitroarginine Methyl Ester
Angiotensin II
Macrophages
Fibrosis
Hypertrophy
2012

Recurrence of Takotsubo cardiomyopathy with coronary slow flow phenomenon

Tokunou, T. & Sadamatsu, K., 4 1 2012, : : Journal of Cardiology Cases. 5, 2

研究成果: ジャーナルへの寄稿記事

No-Reflow Phenomenon
Takotsubo Cardiomyopathy
Coronary Angiography
Ergonovine
Nicorandil
11 引用 (Scopus)

Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells

Ichiki, T., Miyazaki, R., Kamiharaguchi, A., hashimoto, T., Matsuura, H., Kitamoto, S., Tokunou, T. & Sunagawa, K., 8 20 2012, : : Regulatory Peptides. 177, 1-3, p. 35-39 5 p.

研究成果: ジャーナルへの寄稿記事

Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Muscle
Cells
2011
14 引用 (Scopus)

Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor

Matsuura, H., Ichiki, T., Ikeda, J., Takeda, K., Miyazaki, R., Hashimoto, T., Narabayashi, E., Kitamoto, S., Tokunou, T. & Sunagawa, K., 9 1 2011, : : Hypertension. 58, 3, p. 386-393 8 p.

研究成果: ジャーナルへの寄稿記事

Prolyl Hydroxylases
Angiotensin Type 1 Receptor
Blood Vessels
Down-Regulation
Renin-Angiotensin System
2010
20 引用 (Scopus)

Acute effects of isosorbide dinitrate and nicorandil on the coronary slow flow phenomenon

Sadamatsu, K., Tashiro, H., Yoshida, K., Shikada, T., Iwamoto, K., Morishige, K., Yoshidomi, Y., Tokunou, T. & Tanaka, H., 6 14 2010, : : American Journal of Cardiovascular Drugs. 10, 3, p. 203-208 6 p.

研究成果: ジャーナルへの寄稿記事

No-Reflow Phenomenon
Nicorandil
Isosorbide Dinitrate
Myocardial Infarction
Spasm
2009
161 引用 (Scopus)

Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction

Padin-Iruega, M. E., Misao, Y., Davis, M. E., Segers, V. F. M., Esposito, G., Tokunou, T., Urbanek, K., Hosoda, T., Rota, M., Anversa, P., Leri, A., Lee, R. T. & Kajstura, J., 11 17 2009, : : Circulation. 120, 10, p. 876-887 12 p.

研究成果: ジャーナルへの寄稿記事

Nanofibers
Somatomedins
Insulin-Like Growth Factor I
Infarction
Regeneration
2008
23 引用 (Scopus)

Engineering insulin-like growth factor-1 for local delivery

Tokunou, T., Miller, R., Patwari, P., Davis, M. E., Segers, V. F. M., Grodzinsky, A. J. & Lee, R. T., 6 1 2008, : : FASEB Journal. 22, 6, p. 1886-1893 8 p.

研究成果: ジャーナルへの寄稿記事

somatomedins
Somatomedins
engineering
heparin
Heparin
2007
277 引用 (Scopus)

Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction

Segers, V. F. M., Tokunou, T., Higgins, L. J., MacGillivray, C., Gannon, J. & Lee, R. T., 10 1 2007, : : Circulation. 116, 15, p. 1683-1692 10 p.

研究成果: ジャーナルへの寄稿記事

Chemokine CXCL12
Peptide Hydrolases
Stem Cells
Chemokines
Myocardial Infarction
2005
14 引用 (Scopus)

cAMP-response element-binding protein mediates prostaglandin F -induced hypertrophy of vascular smooth muscle cells

Fukuyama, K., Ichiki, T., Ono, H., Tokunou, T., Iino, N., Masuda, S., Ohtsubo, H. & Takeshita, A., 12 16 2005, : : Biochemical and Biophysical Research Communications. 338, 2, p. 910-918 9 p.

研究成果: ジャーナルへの寄稿記事

Cyclic AMP Response Element-Binding Protein
Dinoprost
Prostaglandins F
Vascular Smooth Muscle
Hypertrophy
2004
15 引用 (Scopus)

15-Deoxy-Δ 12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells

Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S. & Takeshita, A., 10 15 2004, : : Biochemical and Biophysical Research Communications. 323, 2, p. 402-408 7 p.

研究成果: ジャーナルへの寄稿記事

Platelet-Derived Growth Factor Receptors
Thiazolidinediones
Vascular Smooth Muscle
Epidermal Growth Factor
Smooth Muscle Myocytes
2003
58 引用 (Scopus)

Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells

Tokunou, T., Shibata, R., Kai, H., Ichiki, T., Morisaki, T., Fukuyama, K., Ono, H., Iino, N., Masuda, S., Shimokawa, H., Egashira, K., Imaizumi, T. & Takeshita, A., 9 9 2003, : : Circulation. 108, 10, p. 1246-1252 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclic AMP Response Element-Binding Protein
Vascular Smooth Muscle
Smooth Muscle Myocytes
Apoptosis
Transcription Factors
39 引用 (Scopus)

Cyclic AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression

Ichiki, T., Tokunou, T., Fukuyama, K., Iino, N., Masuda, S. & Takeshita, A., 8 1 2003, : : Hypertension. 42, 2, p. 177-183 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclic AMP Response Element-Binding Protein
Reactive Oxygen Species
Phosphorylation
Vascular Smooth Muscle
Epidermal Growth Factor Receptor
52 引用 (Scopus)

Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone

Fukuyama, K., Ichiki, T., Takeda, K., Tokunou, T., Iino, N., Masuda, S., Ishibashi, M., Egashira, K., Shimokawa, H., Hirano, K., Kanaide, H. & Takeshita, A., 3 1 2003, : : Hypertension. 41, 3 I, p. 598-603 6 p.

研究成果: ジャーナルへの寄稿記事

Angiotensin Type 1 Receptor
Thyroid Hormones
Angiotensin II
Blood Vessels
Down-Regulation
2002
66 引用 (Scopus)

Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells

Funakoshi, Y., Ichiki, T., Takeda, K., Tokunou, T., Iino, N. & Takeshita, A., 5 24 2002, : : Journal of Biological Chemistry. 277, 21, p. 18710-18717 8 p.

研究成果: ジャーナルへの寄稿記事

Cyclic AMP Response Element-Binding Protein
Vascular Smooth Muscle
Angiotensin II
Hypertrophy
Smooth Muscle Myocytes
2001
126 引用 (Scopus)

15-Deoxy-Δ12,14-prostaglandin J2 and Thiazolidinediones Activate the MEK/ERK Pathway through Phosphatidylinositol 3-Kinase in Vascular Smooth Muscle Cells

Takeda, K., Ichiki, T., Tokunou, T., Iino, N. & Takeshita, A., 12 28 2001, : : Journal of Biological Chemistry. 276, 52, p. 48950-48955 6 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylinositol 3-Kinase
Thiazolidinediones
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Vascular Smooth Muscle
49 引用 (Scopus)

cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells

Tokunou, T., Ichiki, T., Takeda, K., Funakoshi, Y., Iino, N. & Takeshita, A., 1 1 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 11, p. 1764-1769 6 p.

研究成果: ジャーナルへの寄稿記事

Cyclic AMP Response Element-Binding Protein
Vascular Smooth Muscle
Thrombin
Smooth Muscle Myocytes
Phosphorylation
125 引用 (Scopus)

Critical role of rho-kinase and MEK/EFK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression

Takeda, K., Ichiki, T., Tokunou, T., Iino, N., Fujii, S., Kitabatake, A., Shimokawa, H. & Takeshita, A., 5 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 5, p. 868-873 6 p.

研究成果: ジャーナルへの寄稿記事

rho-Associated Kinases
Plasminogen Activator Inhibitor 1
Mitogen-Activated Protein Kinase Kinases
Angiotensin II
Gene Expression
123 引用 (Scopus)

Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in vascular smooth muscle cells

Ichiki, T., Takeda, K., Tokunou, T., Iino, N., Egashira, K., Shimokawa, H., Hirano, K., Kanaide, H. & Takeshita, A., 1 1 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 12, p. 1896-1901 6 p.

研究成果: ジャーナルへの寄稿記事

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Angiotensin Type 1 Receptor
Coenzymes
Vascular Smooth Muscle
fluvastatin
28 引用 (Scopus)

Reactive oxygen species-mediated homologous downregulation of angiotensin II type I receptor mRNA by angiotensin II

Ichiki, T., Takeda, K., Tokunou, T., Funakoshi, Y., Ito, K., Iino, N. & Takeshita, A., 3 19 2001, : : Hypertension. 37, 2 II, p. 535-540 6 p.

研究成果: ジャーナルへの寄稿記事

Angiotensin I
Angiotensin Receptors
Angiotensin II
Reactive Oxygen Species
Down-Regulation
52 引用 (Scopus)

Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells

Tokunou, T., Ichiki, T., Takeda, K., Funakoshi, Y., Iino, N., Shimokawa, H., Egashira, K. & Takeshita, A., 1 1 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 11, p. 1759-1763 5 p.

研究成果: ジャーナルへの寄稿記事

Response Elements
Vascular Smooth Muscle
Thrombin
Smooth Muscle Myocytes
Interleukin-6
2000
164 引用 (Scopus)

Peroxisome proliferator-activated receptor γ activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells

Takeda, K., Ichiki, T., Tokunou, T., Funakoshi, Y., Iino, N., Hirano, K., Kanaide, H. & Takeshita, A., 10 10 2000, : : Circulation. 102, 15, p. 1834-1839 6 p.

研究成果: ジャーナルへの寄稿記事

Angiotensin Type 1 Receptor
Peroxisome Proliferator-Activated Receptors
Vascular Smooth Muscle
Smooth Muscle Myocytes
Down-Regulation