Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1994 2019

2019
1 引用 (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., 1 1 2019, (受理済み/印刷中) : : Purinergic Signalling.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., 3 30 2019, : : Journal of neuroinflammation. 16, 1, 67.

研究成果: ジャーナルへの寄稿記事

公開
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions

Microglia-neuron interactions in the models of neuropathic pain

Saitoh, H. & Makoto, T., 11 1 2019, : : Biochemical Pharmacology. 169, 113614.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Neurons
Chronic Pain
Chemical activation

New approach for investigating neuropathic allodynia by optogenetics

Makoto, T., 5 1 2019, : : Pain. 160, p. S53-S58

研究成果: ジャーナルへの寄稿記事

Optogenetics
Mechanoreceptors
Hyperalgesia
Myelinated Nerve Fibers
Neuralgia
oxaliplatin
Hyperalgesia
Pharmacology
Small Molecule Libraries
Peripheral Nervous System Diseases

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Makoto, T., 3 1 2019, : : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

研究成果: ジャーナルへの寄稿記事

Purinergic P2X3 Receptors
2 引用 (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., 4 1 2019, : : GLIA. 67, 4, p. 729-740 12 p.

研究成果: ジャーナルへの寄稿記事

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2018
6 引用 (Scopus)

Astrocytes in the spinal dorsal horn and chronic itch

Makoto, T., 1 1 2018, : : Neuroscience Research. 126, p. 9-14 6 p.

研究成果: ジャーナルへの寄稿評論記事

Atopic Dermatitis
Astrocytes
Peripheral Nervous System
Central Nervous System
Skin
3 引用 (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 5 1 2018, : : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

研究成果: ジャーナルへの寄稿記事

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., 1 1 2018, : : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia

Interleukin-27 controls basal pain threshold in physiological and pathological conditions

Sasaguri, T., Taguchi, T., Murata, Y., Kobayashi, K., Iizasa, S., Iizasa, E., Tsuda, M., Hirakawa, N., Hara, H., Yoshida, H. & Yasaka, T., 12 1 2018, : : Scientific reports. 8, 1, 11022.

研究成果: ジャーナルへの寄稿記事

Interleukin-27
Pain Threshold
Pain
Chronic Pain
Hypersensitivity
41 引用 (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Makoto, T., 2 16 2018, : : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
2 引用 (Scopus)

Microglia in the CNS and neuropathic pain

Makoto, T., 1 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 77-91 15 p. (Advances in Experimental Medicine and Biology; 巻数 1099).

研究成果: 著書/レポートタイプへの貢献

Microglia
Neuralgia
Neurology
Brain
Nervous System Trauma
13 引用 (Scopus)

Modulation of Pain and Itch by Spinal Glia

Makoto, T., 2 1 2018, : : Neuroscience Bulletin. 34, 1, p. 178-185 8 p.

研究成果: ジャーナルへの寄稿評論記事

Neuroglia
Chronic Pain
Pain
Spinal Cord
Posterior Horn Cells
8 引用 (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Koro, Y., Tominaga, K., Matsushita, K., Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Makoto, T., 1 1 2018, : : eNeuro. 5, 1, e0450-17.2018.

研究成果: ジャーナルへの寄稿記事

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
1 引用 (Scopus)
oxaliplatin
Riluzole
Hyperalgesia
Spinal Ganglia
Oxalates
4 引用 (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 1 1 2018, : : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
17 引用 (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., 12 1 2018, : : Nature communications. 9, 1, 1886.

研究成果: ジャーナルへの寄稿記事

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2017
26 引用 (Scopus)

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Michio, N., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Makoto, T., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S. および1人, Kurose, H., 1 3 2017, : : Journal of Clinical Investigation. 127, 1, p. 383-401 19 p.

研究成果: ジャーナルへの寄稿記事

Myofibroblasts
Myocardial Infarction
Epidermal Growth Factor
Serum Response Factor
Extracellular Matrix Proteins
Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
7 引用 (Scopus)

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T., Hosoi, M., Makoto, T., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., 12 1 2017, : : Scientific reports. 7, 1, 11882.

研究成果: ジャーナルへの寄稿記事

Translational Medical Research
Fibromyalgia
Microglia
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
37 引用 (Scopus)

Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex

Makoto, T., Koga, K., Chen, T. & Zhuo, M., 5 1 2017, : : Journal of Neurochemistry. 141, 4, p. 486-498 13 p.

研究成果: ジャーナルへの寄稿評論記事

Gyrus Cinguli
Neurology
Neuralgia
Chronic Pain
Pain
26 引用 (Scopus)

P2 receptors, microglial cytokines and chemokines, and neuropathic pain

Makoto, T., 6 1 2017, : : Journal of Neuroscience Research. 95, 6, p. 1319-1329 11 p.

研究成果: ジャーナルへの寄稿評論記事

Cytokine Receptors
Chemokine Receptors
Neuralgia
Microglia
Peripheral Nerve Injuries
4 引用 (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
5 引用 (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Makoto, T. & Nishida, M., 6 1 2017, : : Pharmacological Research. 120, p. 51-59 9 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic Receptors
Hypertension
Angiotensin Type 1 Receptor
clopidogrel
Purinergic P2Y12 Receptors
17 引用 (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Makoto, T. & Nishida, M., 12 1 2017, : : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2Y Receptors
G-Protein-Coupled Receptors
Cardiovascular System
Cardiovascular Diseases
Uracil Nucleotides

Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch

Kanehisa, K., Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Takamori, K. & Makoto, T., 11 1 2017, : : Journal of Dermatological Science. 88, 2, p. 251-254 4 p.

研究成果: ジャーナルへの寄稿レター

Cyclopropanes
Muscarinic M3 Receptors
Genetic engineering
Clozapine
Animals
3 引用 (Scopus)

Spinal dorsal horn astrocytes: New players in chronic itch

Tsuda, M., 1 1 2017, : : Allergology International. 66, 1, p. 31-35 5 p.

研究成果: ジャーナルへの寄稿評論記事

Atopic Dermatitis
Astrocytes
Skin
Spinal Cord Dorsal Horn
Therapeutics
2016
30 引用 (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Saitoh, H., Imai, T., Kuraishi, Y., Makoto, T. & Inoue, K., 8 31 2016, : : Scientific reports. 6, 32461.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
16 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
46 引用 (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Koro, Y., Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Makoto, T. & Inoue, K., 8 12 2016, : : Nature communications. 7, 12529.

研究成果: ジャーナルへの寄稿記事

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
17 引用 (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Saitoh, H., Inoue, K. & Makoto, T., 10 1 2016, : : PloS one. 11, 10, e0165189.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
30 引用 (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., 10 14 2016, : : Nature communications. 7, 13102.

研究成果: ジャーナルへの寄稿記事

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
46 引用 (Scopus)

Microglia in the spinal cord and neuropathic pain

Makoto, T., 1 1 2016, : : Journal of Diabetes Investigation. 7, 1, p. 17-26 10 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Neuralgia
Spinal Cord
Purinergic P2X4 Receptors
Pain
39 引用 (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Makoto, T. & Inoue, K., 5 1 2016, : : Neuropharmacology. 104, p. 76-81 6 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors

New mechanism for chronic itch in the nervous system

Makoto, T. & Shiratori, M., 1 1 2016, : : Seikagaku. 88, 5, p. 654-656 3 p.

研究成果: ジャーナルへの寄稿評論記事

Neurology
Animals
Astrocytes
Atopic Dermatitis
28 引用 (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., 1 19 2016, : : Science Signaling. 9, 411, aac9187.

研究成果: ジャーナルへの寄稿記事

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Makoto, T. & Inoue, K., 1 1 2016, : : Seikagaku. 88, 1, p. 124-127 4 p.

研究成果: ジャーナルへの寄稿記事

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia
3 引用 (Scopus)

Transcriptional regulation in microglia and neuropathic pain

Masuda, T., Makoto, T. & Inoue, K., 4 1 2016, : : Pain management. 6, 2, p. 91-94 4 p.

研究成果: ジャーナルへの寄稿編集

公開
Interferon Regulatory Factors
Purinergic P2 Receptors
Gene Expression Regulation
Microglia
Neuralgia
2015
25 引用 (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Koro, Y., Sakaguchi, E., Tashima, R., Saitoh, H., Okano, H., Inoue, K. & Makoto, T., 9 21 2015, : : Scientific reports. 5, 14306.

研究成果: ジャーナルへの寄稿記事

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
2 引用 (Scopus)
Neuralgia
Purinergic P2X4 Receptors
Neuroglia
Microglia
Peripheral Nerve Injuries
8 引用 (Scopus)

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Makoto, T., Inoue, K. & Ueda, T., 3 12 2015, : : FEBS Letters. 589, 6, p. 680-686 7 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Rats
Metals
Head
Cations
56 引用 (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., 8 8 2015, : : Nature medicine. 21, 8, p. 927-931 5 p.

研究成果: ジャーナルへの寄稿記事

STAT3 Transcription Factor
Lipocalins
Atopic Dermatitis
Dermatitis
Gastrin-Releasing Peptide
21 引用 (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., 9 4 2015, : : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Interleukin-1
Transcription Factors
Gene Expression
Up-Regulation
2014
25 引用 (Scopus)

A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation

Yasui, M., Yoshimura, T., Takeuchi, S., Tokizane, K., Makoto, T., Inoue, K. & Kiyama, H., 1 1 2014, : : GLIA. 62, 9, p. 1407-1417 11 p.

研究成果: ジャーナルへの寄稿記事

Chronic Fatigue Syndrome
Hyperalgesia
Pain
Microglia
Minocycline
36 引用 (Scopus)

Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain

Matsushita, K., Tozaki-Saitoh, H., Kojima, C., Masuda, T., Tsuda, M., Inoue, K. & Hoka, S., 6 2014, : : Anesthesiology. 120, 6, p. 1491-1503 13 p.

研究成果: ジャーナルへの寄稿記事

CCR Receptors
Neuralgia
Hyperalgesia
Chemokine CCL3
Maintenance
10 引用 (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Saitoh, H., Tamura, T., Mizumura, K., Makoto, T., Kiyama, H. & Inoue, K., 1 1 2014, : : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

研究成果: ジャーナルへの寄稿記事

Hyperalgesia
Microglia
Rodentia
interferon regulatory factor-8
Knockout Mice
27 引用 (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., 8 15 2014, : : Molecular Pain. 10, 1, 53.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X7 Receptors
CC Chemokines
Hyperalgesia
Paclitaxel
Chemokines