Pureに変更を加えた場合、すぐここに表示されます。

研究成果 1994 2019

フィルター
記事
2019
1 引用 (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., 1 1 2019, (受理済み/印刷中) : : Purinergic Signalling.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., 3 30 2019, : : Journal of neuroinflammation. 16, 1, 67.

研究成果: ジャーナルへの寄稿記事

公開
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions

New approach for investigating neuropathic allodynia by optogenetics

Makoto, T., 5 1 2019, : : Pain. 160, p. S53-S58

研究成果: ジャーナルへの寄稿記事

Optogenetics
Mechanoreceptors
Hyperalgesia
Myelinated Nerve Fibers
Neuralgia
oxaliplatin
Hyperalgesia
Pharmacology
Small Molecule Libraries
Peripheral Nervous System Diseases

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Makoto, T., 3 1 2019, : : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

研究成果: ジャーナルへの寄稿記事

Purinergic P2X3 Receptors
2 引用 (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., 4 1 2019, : : GLIA. 67, 4, p. 729-740 12 p.

研究成果: ジャーナルへの寄稿記事

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2018
3 引用 (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 5 1 2018, : : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

研究成果: ジャーナルへの寄稿記事

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Interleukin-27 controls basal pain threshold in physiological and pathological conditions

Sasaguri, T., Taguchi, T., Murata, Y., Kobayashi, K., Iizasa, S., Iizasa, E., Tsuda, M., Hirakawa, N., Hara, H., Yoshida, H. & Yasaka, T., 12 1 2018, : : Scientific reports. 8, 1, 11022.

研究成果: ジャーナルへの寄稿記事

Interleukin-27
Pain Threshold
Pain
Chronic Pain
Hypersensitivity
8 引用 (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Koro, Y., Tominaga, K., Matsushita, K., Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Makoto, T., 1 1 2018, : : eNeuro. 5, 1, e0450-17.2018.

研究成果: ジャーナルへの寄稿記事

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
1 引用 (Scopus)
oxaliplatin
Riluzole
Hyperalgesia
Spinal Ganglia
Oxalates
4 引用 (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 1 1 2018, : : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
17 引用 (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., 12 1 2018, : : Nature communications. 9, 1, 1886.

研究成果: ジャーナルへの寄稿記事

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2017
26 引用 (Scopus)

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Michio, N., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Makoto, T., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S. および1人, Kurose, H., 1 3 2017, : : Journal of Clinical Investigation. 127, 1, p. 383-401 19 p.

研究成果: ジャーナルへの寄稿記事

Myofibroblasts
Myocardial Infarction
Epidermal Growth Factor
Serum Response Factor
Extracellular Matrix Proteins
Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
7 引用 (Scopus)

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T., Hosoi, M., Makoto, T., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., 12 1 2017, : : Scientific reports. 7, 1, 11882.

研究成果: ジャーナルへの寄稿記事

Translational Medical Research
Fibromyalgia
Microglia
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
4 引用 (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
2016
30 引用 (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Saitoh, H., Imai, T., Kuraishi, Y., Makoto, T. & Inoue, K., 8 31 2016, : : Scientific reports. 6, 32461.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
16 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
46 引用 (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Koro, Y., Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Makoto, T. & Inoue, K., 8 12 2016, : : Nature communications. 7, 12529.

研究成果: ジャーナルへの寄稿記事

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
17 引用 (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Saitoh, H., Inoue, K. & Makoto, T., 10 1 2016, : : PloS one. 11, 10, e0165189.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
30 引用 (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., 10 14 2016, : : Nature communications. 7, 13102.

研究成果: ジャーナルへの寄稿記事

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
46 引用 (Scopus)

Microglia in the spinal cord and neuropathic pain

Makoto, T., 1 1 2016, : : Journal of Diabetes Investigation. 7, 1, p. 17-26 10 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Neuralgia
Spinal Cord
Purinergic P2X4 Receptors
Pain
28 引用 (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Makoto, T., Robaye, B., Inoue, K. & Nishida, M., 1 19 2016, : : Science Signaling. 9, 411, aac9187.

研究成果: ジャーナルへの寄稿記事

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Makoto, T. & Inoue, K., 1 1 2016, : : Seikagaku. 88, 1, p. 124-127 4 p.

研究成果: ジャーナルへの寄稿記事

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia
2015
25 引用 (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Koro, Y., Sakaguchi, E., Tashima, R., Saitoh, H., Okano, H., Inoue, K. & Makoto, T., 9 21 2015, : : Scientific reports. 5, 14306.

研究成果: ジャーナルへの寄稿記事

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
8 引用 (Scopus)

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Makoto, T., Inoue, K. & Ueda, T., 3 12 2015, : : FEBS Letters. 589, 6, p. 680-686 7 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Rats
Metals
Head
Cations
56 引用 (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., 8 8 2015, : : Nature medicine. 21, 8, p. 927-931 5 p.

研究成果: ジャーナルへの寄稿記事

STAT3 Transcription Factor
Lipocalins
Atopic Dermatitis
Dermatitis
Gastrin-Releasing Peptide
21 引用 (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., 9 4 2015, : : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Interleukin-1
Transcription Factors
Gene Expression
Up-Regulation
2014
25 引用 (Scopus)

A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation

Yasui, M., Yoshimura, T., Takeuchi, S., Tokizane, K., Makoto, T., Inoue, K. & Kiyama, H., 1 1 2014, : : GLIA. 62, 9, p. 1407-1417 11 p.

研究成果: ジャーナルへの寄稿記事

Chronic Fatigue Syndrome
Hyperalgesia
Pain
Microglia
Minocycline
36 引用 (Scopus)

Chemokine (C-C motif) receptor 5 Is an important pathological regulator in the development and maintenance of neuropathic pain

Matsushita, K., Tozaki-Saitoh, H., Kojima, C., Masuda, T., Tsuda, M., Inoue, K. & Hoka, S., 6 2014, : : Anesthesiology. 120, 6, p. 1491-1503 13 p.

研究成果: ジャーナルへの寄稿記事

CCR Receptors
Neuralgia
Hyperalgesia
Chemokine CCL3
Maintenance
10 引用 (Scopus)

Interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents

Akagi, T., Matsumura, Y., Yasui, M., Minami, E., Inoue, H., Masuda, T., Saitoh, H., Tamura, T., Mizumura, K., Makoto, T., Kiyama, H. & Inoue, K., 1 1 2014, : : Journal of Pharmacological Sciences. 126, 2, p. 172-176 5 p.

研究成果: ジャーナルへの寄稿記事

Hyperalgesia
Microglia
Rodentia
interferon regulatory factor-8
Knockout Mice
27 引用 (Scopus)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia

Ochi-ishi, R., Nagata, K., Inoue, T., Tozaki-Saitoh, H., Tsuda, M. & Inoue, K., 8 15 2014, : : Molecular Pain. 10, 1, 53.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X7 Receptors
CC Chemokines
Hyperalgesia
Paclitaxel
Chemokines
13 引用 (Scopus)

IRF8 is a transcriptional determinant for microglial motility

Masuda, T., Nishimoto, N., Tomiyama, D., Matsuda, T., Saitoh, H., Tamura, T., Kohsaka, S., Makoto, T. & Inoue, K., 1 1 2014, : : Purinergic Signalling. 10, 3, p. 515-521 7 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Chemotaxis
Adenosine Triphosphate
Complement C5a
interferon regulatory factor-8

Spinal cord is the primary site of action of the cannabinoid CB2 receptor agonist JWH133 that suppresses neuropathic pain: Possible involvement of microglia

Shimoyama, H., Makoto, T., Masuda, T., Yoshinaga, R., Tsukamoto, K., Saitoh, H. & Inoue, K., 1 1 2014, : : Open Pain Journal. 7, 1

研究成果: ジャーナルへの寄稿記事

Cannabinoid Receptor Agonists
Microglia
Neuralgia
Cannabinoid Receptor CB2
Spinal Cord
76 引用 (Scopus)

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki-Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M. & Inoue, K., 5 13 2014, : : Nature communications. 5, 3771.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Interferon Regulatory Factors
interferon
pain
Microglia
2013
30 引用 (Scopus)

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio, N., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Makoto, T., Kuroda, M., Inoue, K. & Kurose, H., 3 11 2013, : : Nature communications. 4, 1532.

研究成果: ジャーナルへの寄稿記事

clearances
Autoimmune Diseases
mice
Cells
proteins
78 引用 (Scopus)

Microglia and intractable chronic pain

Tsuda, M., Beggs, S., Salter, M. W. & Inoue, K., 1 1 2013, : : GLIA. 61, 1, p. 55-61 7 p.

研究成果: ジャーナルへの寄稿記事

Intractable Pain
Microglia
Neuralgia
Chronic Pain
Peripheral Nervous System Diseases
5 引用 (Scopus)

Preparation and characterization of a monoclonal antibody against the refolded and functional extracellular domain of rat P2X4 receptor

Igawa, T., Higashi, S., Abe, Y., Ohkuri, T., Tanaka, H., Morimoto, S., Yamashita, T., Makoto, T., Inoue, K. & Ueda, T., 3 1 2013, : : Journal of Biochemistry. 153, 3, p. 275-282 8 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Rats
Monoclonal Antibodies
Molecules
Neuralgia
2012
6 引用 (Scopus)

(R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects

Muratake, H., Ito, A., Toda, T., Suzuki, H., Fukasawa, H., Makoto, T., Inoue, K., Sugiyama, K. & Shudo, K., 12 15 2012, : : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7602-7604 3 p.

研究成果: ジャーナルへの寄稿記事

Neurology
Neuralgia
Central Nervous System
Anticonvulsants
Aminobutyrates
53 引用 (Scopus)

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Toyomitsu, E., Tsuda, M., Yamashita, T., Tozaki-Saitoh, H., Tanaka, Y. & Inoue, K., 6 1 2012, : : Purinergic Signalling. 8, 2, p. 301-310 10 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Microglia
Lysosomes
Exocytosis
Green Fluorescent Proteins
11 引用 (Scopus)

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

Uesugi, A., Kataoka, A., Saitoh, H., Koga, Y., Makoto, T., Robaye, B., Boeynaems, J. M. & Inoue, K., 7 1 2012, : : GLIA. 60, 7, p. 1094-1105 12 p.

研究成果: ジャーナルへの寄稿記事

Uridine Diphosphate
Phagocytosis
Microglia
Microspheres
Vacuoles
129 引用 (Scopus)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

Masuda, T., Makoto, T., Yoshinaga, R., Saitoh, H., Ozato, K., Tamura, T. & Inoue, K., 3 19 2012, : : Cell Reports. 1, 4, p. 334-340 7 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Transcription Factors
Phenotype
Peripheral Nerve Injuries
Gene expression
35 引用 (Scopus)

Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain

Sun, L., Wu, Z., Hayashi, Y., Peters, C., Tsuda, M., Inoue, K. & Nakanishi, H., 8 15 2012, : : Journal of Neuroscience. 32, 33, p. 11330-11342 13 p.

研究成果: ジャーナルへの寄稿記事

Cathepsin B
Chronic Pain
Inflammation
Caspase 1
Interleukin-1
4 引用 (Scopus)

P2X4R and P2X7R in neuropathic pain

Makoto, T., Hidetoshi, T. S. & Kazuhide, I., 7 1 2012, : : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1, 4, p. 513-521 9 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Purinergic Receptors
Microglia
Purinergic P2 Receptors
Posterior Horn Cells
16 引用 (Scopus)

P2X4 receptors of microglia in neuropathic pain

Inoue, K. & Makoto, T., 11 19 2012, : : CNS and Neurological Disorders - Drug Targets. 11, 6, p. 699-704 6 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Microglia
Neuralgia
Purinergic P2Y12 Receptors
Purinergic P2X7 Receptors
2011
55 引用 (Scopus)
Purinergic P2Y1 Receptors
Middle Cerebral Artery Infarction
Brain Ischemia
Chemokines
Chemokine CXCL10
4 引用 (Scopus)

Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways

Kataoka, A., Koga, Y., Uesugi, A., Saitoh, H., Makoto, T. & Inoue, K., 12 1 2011, : : Purinergic Signalling. 7, 4, p. 403-411 9 p.

研究成果: ジャーナルへの寄稿記事

Uridine Diphosphate
Actins
Microglia
Phosphorylation
Microfilament Proteins
142 引用 (Scopus)

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

Makoto, T., Koro, Y., Yano, T., Tsujikawa, T., Kitano, J., Saitoh, H., Satoru, K., Ohdo, S., Ji, R. R., Salter, M. W. & Inoue, K., 4 1 2011, : : Brain. 134, 4, p. 1127-1139 13 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
STAT3 Transcription Factor
Astrocytes
Maintenance
Janus Kinases