• 3817 引用
  • 34 h指数
1989 …2020

Research output per year

Pureに変更を加えた場合、すぐここに表示されます。

研究成果

  • 3817 引用
  • 34 h指数
  • 91 記事
  • 5 評論記事
  • 2 コメント/討論
2020

DOCK family proteins: key players in immune surveillance mechanisms

Kunimura, K., Uruno, T. & Fukui, Y., 1 9 2020, : : International immunology. 32, 1, p. 5-15 11 p.

研究成果: ジャーナルへの寄稿記事

公開
2019

S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches

Kunimura, K., Sakata, D., Tun, X., Uruno, T., Ushijima, M., Katakai, T., Shiraishi, A., Aihara, R., Kamikaseda, Y., Matsubara, K., Kanegane, H., Sawa, S., Eberl, G., Ohga, S., Yoshikai, Y. & Fukui, Y., 11 26 2019, : : Cell Reports. 29, 9, p. 2823-2834.e7

研究成果: ジャーナルへの寄稿記事

公開
1 引用 (Scopus)

Selective role of neurokinin B in IL-31–induced itch response in mice

Sakata, D., Uruno, T., Matsubara, K., Andoh, T., Yamamura, K., Magoshi, Y., Kunimura, K., Kamikaseda, Y., Furue, M. & Fukui, Y., 10 1 2019, : : Journal of Allergy and Clinical Immunology. 144, 4, p. 1130-1133.e8

研究成果: ジャーナルへの寄稿記事

公開
1 引用 (Scopus)
2018

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., 7 31 2018, : : Science Signaling. 11, 541, eaao4874.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fukui, Y., 7 31 2018, : : Science Signaling. 11, 541

研究成果: ジャーナルへの寄稿記事

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation

Tomino, T., Tajiri, H., Tatsuguchi, T., Shirai, T., Oisaki, K., Matsunaga, S., Sanematsu, F., Sakata, D., Yoshizumi, T., Maehara, Y., Kanai, M., Cote, J. F., Fukui, Y. & Uruno, T., 2 26 2018, : : Biochemical and Biophysical Research Communications. 497, 1, p. 298-304 7 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)
51 引用 (Scopus)

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Gotoh, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. & Kang, D., 11 13 2018, : : Cell Reports. 25, 7, p. 1800-1815.e4

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production

Ushijima, M., Uruno, T., Nishikimi, A., Sanematsu, F., Kamikaseda, Y., Kunimura, K., Sakata, D., Okada, T. & Fukui, Y., 2 16 2018, : : Frontiers in Immunology. 9, FEB, 243.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)
2017

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

Peters, L. A., Perrigoue, J., Mortha, A., Iuga, A., Song, W. M., Neiman, E. M., Llewellyn, S. R., Di Narzo, A., Kidd, B. A., Telesco, S. E., Zhao, Y., Stojmirovic, A., Sendecki, J., Shameer, K., Miotto, R., Losic, B., Shah, H., Lee, E., Wang, M., Faith, J. J. および18人, Kasarskis, A., Brodmerkel, C., Curran, M., Das, A., Friedman, J. R., Fukui, Y., Humphrey, M. B., Iritani, B. M., Sibinga, N., Tarrant, T. K., Argmann, C., Hao, K., Roussos, P., Zhu, J., Zhang, B., Dobrin, R., Mayer, L. F. & Schadt, E. E., 10 1 2017, : : Nature genetics. 49, 10, p. 1437-1449 13 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Antigen availability and DOCK2-driven motility govern CD4+ t cell interactions with dendritic cells in vivo

Ackerknecht, M., Gollmer, K., Germann, P., Ficht, X., Abe, J., Fukui, Y., Swoger, J., Ripoll, J., Sharpe, J. & Stein, J. V., 7 15 2017, : : Journal of Immunology. 199, 2, p. 520-530 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse [The Journal of Experimental Medicine, 210, 12, November 18, (2013) 2721-2737]doi 10.1084/jem.20131324

Le Floc'h, A., Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y. & Huse, M., 4 1 2017, : : Journal of Experimental Medicine. 214, 4, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

DOCK8 protein regulates macrophage migration through Cdc42 protein activation and LRAP35a protein interaction

Shiraishi, A., Uruno, T., Sanematsu, F., Ushijima, M., Sakata, D., Hara, T. & Fukui, Y., 2 10 2017, : : Journal of Biological Chemistry. 292, 6, p. 2191-2202 12 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

Tajiri, H., Uruno, T., Shirai, T., Takaya, D., Matsunaga, S., Setoyama, D., Watanabe, M., Kukimoto-Niino, M., Oisaki, K., Ushijima, M., Sanematsu, F., Honma, T., Terada, T., Oki, E., Shirasawa, S., Maehara, Y., Kang, D., Côté, J. F., Yokoyama, S., Kanai, M. および1人, Fukui, Y., 5 2 2017, : : Cell Reports. 19, 5, p. 969-980 12 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

The AP-1 transcription factor JunB is required for Th17 cell differentiation

Yamazaki, S., Tanaka, Y., Araki, H., Kohda, A., Sanematsu, F., Arasaki, T., Duan, X., Miura, F., Katagiri, T., Shindo, R., Nakano, H., Ito, T., Fukui, Y., Endo, S. & Sumimoto, H., 12 1 2017, : : Scientific reports. 7, 1, 17402.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Yamamura, K., Uruno, T., Shiraishi, A., Tanaka, Y., Ushijima, M., Nakahara, T., Watanabe, M., Kido-Nakahara, M., Tsuge, I., Furue, M. & Fukui, Y., 1 9 2017, : : Nature communications. 8, 13946.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)
1 引用 (Scopus)

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2

Okumura, F., Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., 11 15 2017, : : Molecular biology of the cell. 28, 24, p. 3532-3541 10 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)
2016

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation

Uematsu, K., Okumura, F., Tonogai, S., Joo-Okumura, A., Alemayehu, D. H., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., 1 1 2016, : : Journal of Cell Biology. 215, 1, 95.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection

Liu, Z., Man, S. M., Zhu, Q., Vogel, P., Frase, S., Fukui, Y. & Kanneganti, T. D., 6 13 2016, : : Scientific reports. 6, 27814.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Parallel regulation of von Hippel-Lindau disease by pVHL-mediated degradation of B-Myb and hypoxia-inducible factor α

Okumura, F., Uematsu, K., Byrne, S. D., Hirano, M., Joo-Okumura, A., Nishikimi, A., Shuin, T., Fukui, Y., Nakatsukasa, K. & Kamura, T., 6 1 2016, : : Molecular and cellular biology. 36, 12, p. 1803-1817 15 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)
2015

Axl phosphorylates Elmo scaffold proteins to promote rac activation and cell invasion

Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R. A., Gratton, J. P. & Côté, J. F., 1 1 2015, : : Molecular and cellular biology. 35, 1, p. 76-87 12 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling

Guo, X., Shi, N., Cui, X. B., Wang, J. N., Fukui, Y. & Chen, S. Y., 5 8 2015, : : Circulation research. 116, 10, p. e71-e80

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

Yanagihara, T., Sanematsu, F., Sato, T., Uruno, T., Duan, X., Tomino, T., Harada, Y., Watanabe, M., Wang, Y., Tanaka, Y., Nakanishi, Y., Suyama, M. & Yoshinori, F., 11 4 2015, : : Nature communications. 6, 8820.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)
2014

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation

Watanabe, M., Terasawa, M., Miyano, K., Yanagihara, T., Uruno, T., Sanematsu, F., Nishikimi, A., Côté, J. F., Sumimoto, H. & Fukui, Y., 12 1 2014, : : Journal of Immunology. 193, 11, p. 5660-5667 8 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

DOCK2 is critical for CD8+TCR- graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells

Wen, Y., Elliott, M. J., Huang, Y., Miller, T. O., Corbin, D. R., Hussain, L. R., Ratajczak, M. Z., Fukui, Y. & Ildstad, S. T., 1 1 2014, : : STEM CELLS. 32, 10, p. 2732-2743 12 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

Ogawa, K., Tanaka, Y., Uruno, T., Duan, X., Harada, Y., Sanematsu, F., Yamamura, K., Terasawa, M., Nishikimi, A., Côté, J. F. & Fukui, Y., 6 2014, : : Journal of Experimental Medicine. 211, 7, p. 1407-1419 13 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

Neutrophils scan for activated platelets to initiate inflammation

Sreeramkumar, V., Adrover, J. M., Ballesteros, I., Cuartero, M. I., Rossaint, J., Bilbao, I., Nácher, M., Pitaval, C., Radovanovic, I., Fukui, Y., McEver, R. P., Filippi, M. D., Lizasoain, I., Ruiz-Cabello, J., Zarbock, A., Moro, M. A. & Hidalgo, A., 12 5 2014, : : Science. 346, 6214, p. 1234-1238 5 p.

研究成果: ジャーナルへの寄稿記事

248 引用 (Scopus)

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

Damoulakis, G., Gambardella, L., Rossman, K. L., Lawson, C. D., Anderson, K. E., Fukui, Y., Welch, H. C., Der, C. J., Stephens, L. R. & Hawkins, P. T., 6 2014, : : Journal of cell science. 127, 11, p. 2589-2600 12 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions

Moalli, F., Cupovic, J., Thelen, F., Halbherr, P., Fukui, Y., Narumiya, S., Ludewig, B. & Stein, J. V., 1 1 2014, : : Journal of Experimental Medicine. 211, 13, p. 2507-2517 11 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)
2013

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease

Cimino, P. J., Yang, Y., Li, X., Hemingway, J. F., Cherne, M. K., Khademi, S. B., Fukui, Y., Montine, K. S., Montine, T. J. & Keene, C. D., 4 1 2013, : : Experimental and Molecular Pathology. 94, 2, p. 366-371 6 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

Floc'h, A. L., Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y. & Huse, M., 11 2013, : : Journal of Experimental Medicine. 210, 12, p. 2721-2737 17 p.

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

Immune regulatory functions of DOCK family proteins in health and disease

Nishikimi, A., Kukimoto-Niino, M., Yokoyama, S. & Fukui, Y., 9 10 2013, : : Experimental Cell Research. 319, 15, p. 2343-2349 7 p.

研究成果: ジャーナルへの寄稿評論記事

38 引用 (Scopus)

Lysyl 5-hydroxylation, a novel histone modification, by jumonji domain containing 6 (JMJD6)

Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y., 3 1 2013, : : Journal of Biological Chemistry. 288, 9, p. 6053-6062 10 p.

研究成果: ジャーナルへの寄稿記事

75 引用 (Scopus)

Phosphatidic acid-dependent recruitment and function of the rac activator DOCK1 during dorsal ruffle formation

Sanematsu, F., Nishikimi, A., Watanabe, M., Hongu, T., Tanaka, Y., Kanaho, Y., Côté, J. F. & Fukui, Y., 3 22 2013, : : Journal of Biological Chemistry. 288, 12, p. 8092-8100 9 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

Laurin, M., Huber, J., Pelletier, A., Houalla, T., Park, M., Fukui, Y., Haibe-Kains, B., Muller, W. J. & Côté, J. F., 4 30 2013, : : Proceedings of the National Academy of Sciences of the United States of America. 110, 18, p. 7434-7439 6 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

The cell polarity protein minsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway

Kamakura, S., Nomura, M., Hayase, J., Iwakiri, Y., Nishikimi, A., Takayanagi, R., Fukui, Y. & Sumimoto, H., 8 12 2013, : : Developmental Cell. 26, 3, p. 292-302 11 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation

Sakai, Y., Tanaka, Y., Yanagihara, T., Watanabe, M., Duan, X., Terasawa, M., Nishikimi, A., Sanematsu, F. & Fukui, Y., 7 18 2013, : : Blood. 122, 3, p. 386-393 8 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo

Laurin, M., Dumouchel, A., Fukui, Y. & Côté, J. F., 2013, : : Small GTPases. 4, 4, p. 221-230 10 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)
2012

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2

Nishikimi, A., Uruno, T., Duan, X., Cao, Q., Okamura, Y., Saitoh, T., Saito, N., Sakaoka, S., Du, Y., Suenaga, A., Kukimoto-Niino, M., Miyano, K., Gotoh, K., Okabe, T., Sanematsu, F., Tanaka, Y., Sumimoto, H., Honma, T., Yokoyama, S., Nagano, T. および3人, Kohda, D., Kanai, M. & Fukui, Y., 4 20 2012, : : Chemistry and Biology. 19, 4, p. 488-497 10 p.

研究成果: ジャーナルへの寄稿記事

42 引用 (Scopus)

Defective Dock2 expression in a subset of ASC-deficient mouse lines

Ippagunta, S. K., Malireddi, R. K. S., Shaw, P. J., Neale, G. A., Walle, L. V., Fukui, Y., Green, D. R., Lamkanfi, M. & Kanneganti, T. D., 1 1 2012, : : Nature Immunology. 13, 7, p. 701-702 2 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

Terasawa, M., Uruno, T., Mori, S., Kukimoto-Niino, M., Nishikimi, A., Sanematsu, F., Tanaka, Y., Yokoyama, S. & Fukui, Y., 9 26 2012, : : PloS one. 7, 9, e46277.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Kyoko, H. S., Mutsuko, K. N., Nishizaki, T., Shirouzu, M., Duan, X., Uruno, T., Nishikimi, A., Sanematsu, F., Yokoyama, S., Stein, J. V., Kinashi, T. & Fukui, Y., 5 10 2012, : : Blood. 119, 19, p. 4451-4461 11 p.

研究成果: ジャーナルへの寄稿記事

122 引用 (Scopus)

Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data

Fujimori, S., Hirai, N., Ohashi, H., Masuoka, K., Nishikimi, A., Fukui, Y., Washio, T., Oshikubo, T., Yamashita, T. & Miyamoto-Sato, E., 11 7 2012, : : Scientific reports. 2, 691.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S. I., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., Terada, T., Shirouzu, M., Nishikimi, A., Uruno, T., Katakai, T., Kinashi, T., Kohda, D., Fukui, Y. & Yokoyama, S., 2 28 2012, : : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3305-3310 6 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

The mechanism controlling leukocyte trafficking for acquired immune responses

Fukui, Y., 12 1 2012, : : Seikagaku. 84, 3, p. 189-194 6 p.

研究成果: ジャーナルへの寄稿評論記事

2011

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

Ippagunta, S. K., Malireddi, R. K. S., Shaw, P. J., Neale, G. A., Walle, L. V., Green, D. R., Fukui, Y., Lamkanfi, M. & Kanneganti, T. D., 10 1 2011, : : Nature Immunology. 12, 10, p. 1010-1016 7 p.

研究成果: ジャーナルへの寄稿記事

74 引用 (Scopus)
2010

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

Boscacci, R. T., Pfeiffer, F., Gollmer, K., Sevilla, A. I. C., Martin, A. M., Soriano, S. F., Natale, D., Henrickson, S., Von Andrian, U. H., Fukui, Y., Mellado, M., Deutsch, U., Engelhardt, B. & Stein, J. V., 8 12 2010, : : Blood. 116, 6, p. 915-925 11 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 10 29 2010, : : Circulation research. 107, 9, p. 1102-1105 4 p.

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)