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研究成果 2003 2019

フィルター
記事
2019
10 引用 (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: ジャーナルへの寄稿記事

公開
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms
11 引用 (Scopus)

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Nakano, M., Kikushige, Y., Miyawaki, K., Kunisaki, Y., Mizuno, S., Takenaka, K., Tamura, S., Okumura, Y., Ito, M., Ariyama, H., Kusaba, H., Nakamura, M., Maeda, T., Baba, E. & Akashi, K., 2 7 2019, : : Oncogene. 38, 6, p. 780-793 14 p.

研究成果: ジャーナルへの寄稿記事

Neoplastic Stem Cells
Transforming Growth Factor beta
Colorectal Neoplasms
Stem Cells
Organoids
2 引用 (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., 12 1 2019, : : Nature communications. 10, 1, 1072.

研究成果: ジャーナルへの寄稿記事

公開
homeostasis
stem cells
Hematopoietic Stem Cells
Homeostasis
hematopoiesis
2018
2 引用 (Scopus)
Graft vs Host Disease
Hematopoietic Stem Cells
Transplants
Infection
Dysbiosis
2017
106 引用 (Scopus)

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., 3 1 2017, : : Nature Cell Biology. 19, 3, p. 214-223 10 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Hematopoietic Stem Cells
Cytokines
Leptin Receptors
Neuroglia
16 引用 (Scopus)

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., Mori, Y., Arinobu, Y., Tsuzuki, H., Kikushige, Y., Iino, T., Kato, K., Takenaka, K., Miyamoto, T., Maeda, T. & Akashi, K., 6 22 2017, : : Blood. 129, 25, p. 3332-3343 12 p.

研究成果: ジャーナルへの寄稿記事

Megakaryocyte Progenitor Cells
Megakaryocytes
Hematopoiesis
Cells
Janus Kinase 2
2016
9 引用 (Scopus)

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., 9 13 2016, : : Stem Cell Reports. 7, 3, p. 425-438 14 p.

研究成果: ジャーナルへの寄稿記事

Thrombopoiesis
Erythropoiesis
Bone
Cells
Clodronic Acid
89 引用 (Scopus)

Fetal liver hematopoietic stem cell niches associate with portal vessels

Khan, J. A., Mendelson, A., Kunisaki, Y., Birbrair, A., Kou, Y., Arnal-Estapé, A., Pinho, S., Ciero, P., Nakahara, F., Ma'ayan, A., Bergman, A., Merad, M. & Frenette, P. S., 1 1 2016, : : Science. 351, 6269, p. 176-180 5 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Nestin
Hematopoietic Stem Cells
Fractals
Liver
2015
2 引用 (Scopus)

Distinct vascular niches determine hematopoietic stem cell fate

Kunisaki, Y., 6 1 2015, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 6, p. 606-613 8 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Blood Vessels
Arterioles
Stem Cell Niche
Nestin
209 引用 (Scopus)

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J. E., Scheiermann, C., Merad, M. & Frenette, P. S., 9 24 2015, : : Nature. 525, 7570, p. 528-532 5 p.

研究成果: ジャーナルへの寄稿記事

Microbiota
Neutrophils
Bone Marrow
Myeloid Differentiation Factor 88
CXCR4 Receptors
1 引用 (Scopus)

The hematopoietic stem cell niche

Kunisaki, Y., 10 1 2015, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 10, p. 1888-1893 6 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Hematopoietic Stem Cells
Homeostasis
Stem Cells
Bone Marrow
2014
141 引用 (Scopus)

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell Niche

Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U. & Frenette, P. S., 1 1 2014, : : Cell stem cell. 15, 3, p. 365-375 11 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Acute Myeloid Leukemia
Sympathetic Nervous System
18 引用 (Scopus)

Influences of vascular niches on hematopoietic stem cell fate

Kunisaki, Y. & Frenette, P. S., 6 2014, : : International journal of hematology. 99, 6, p. 699-705 7 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Blood Vessels
Bone Marrow
Stem Cell Niche
Arterioles
233 引用 (Scopus)

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

Bruns, I., Lucas, D., Pinho, S., Ahmed, J., Lambert, M. P., Kunisaki, Y., Scheiermann, C., Schiff, L., Poncz, M., Bergman, A. & Frenette, P. S., 11 1 2014, : : Nature medicine. 20, 11, p. 1315-1320 6 p.

研究成果: ジャーナルへの寄稿記事

Megakaryocytes
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
158 引用 (Scopus)

Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development

Mizoguchi, T., Pinho, S., Ahmed, J., Kunisaki, Y., Hanoun, M., Mendelson, A., Ono, N., Kronenberg, H. M. & Frenette, P. S., 5 12 2014, : : Developmental Cell. 29, 3, p. 340-349 10 p.

研究成果: ジャーナルへの寄稿記事

Bone Development
Mesenchymal Stromal Cells
Bone
Bone Marrow
Stromal Cells
2013
528 引用 (Scopus)

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J. C., Bergman, A. & Frenette, P. S., 10 10 2013, : : Nature. 502, 7473, p. 637-643 7 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Bone Marrow
Leptin Receptors
Arterioles
Stromal Cells
198 引用 (Scopus)

CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress

Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., Van Rooijen, N., Tanaka, M., Zhao, Z. J., Bergman, A., Merad, M. & Frenette, P. S., 4 1 2013, : : Nature medicine. 19, 4, p. 429-436 8 p.

研究成果: ジャーナルへの寄稿記事

Macrophages
Erythropoiesis
Homeostasis
Erythroblasts
Polycythemia Vera
113 引用 (Scopus)

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L. & Frenette, P. S., 6 1 2013, : : Nature medicine. 19, 6, p. 695-703 9 p.

研究成果: ジャーナルへの寄稿記事

Chemotherapy
Regeneration
Bone
Bone Marrow
Drug Therapy
225 引用 (Scopus)

PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

Pinho, S., Lacombe, J., Hanoun, M., Mizoguchi, T., Bruns, I., Kunisaki, Y. & Frenette, P. S., 7 1 2013, : : Journal of Experimental Medicine. 210, 7, p. 1351-1367 17 p.

研究成果: ジャーナルへの寄稿記事

Nestin
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Stem Cell Niche
Stem Cells
231 引用 (Scopus)

XRhythmic modulation of the hematopoietic niche through neutrophil clearance

Casanova-Acebes, M., Pitaval, C., Weiss, L. A., Nombela-Arrieta, C., Chèvre, R., A-González, N., Kunisaki, Y., Zhang, D., Van Rooijen, N., Silberstein, L. E., Weber, C., Nagasawa, T., Frenette, P. S., Castrillo, A. & Hidalgo, A., 5 23 2013, : : Cell. 153, 5, 1 p.

研究成果: ジャーナルへの寄稿記事

Bone
Neutrophils
Modulation
Macrophages
Bone Marrow
2012
197 引用 (Scopus)

Adrenergic nerves govern circadian leukocyte recruitment to tissues

Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A., Jang, J. E., Zhang, D., Hashimoto, D., Merad, M. & Frenette, P. S., 8 24 2012, : : Immunity. 37, 2, p. 290-301 12 p.

研究成果: ジャーナルへの寄稿記事

Adrenergic Agents
Leukocytes
Sympathetic Nervous System
Cell Adhesion Molecules
Septic Shock
54 引用 (Scopus)

Norepinephrine reuptake inhibition promotes mobilization in mice: Potential impact to rescue low stem cell yields

Lucas, D., Bruns, I., Battista, M., Mendez-Ferrer, S., Magnon, C., Kunisaki, Y. & Frenette, P. S., 4 19 2012, : : Blood. 119, 17, p. 3962-3965 4 p.

研究成果: ジャーナルへの寄稿記事

Granulocyte Colony-Stimulating Factor
Stem cells
Norepinephrine
Stem Cells
Peripheral Nerves
2011
86 引用 (Scopus)

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

Hashimoto, D., Chow, A., Greter, M., Saenger, Y., Kwan, W. H., Leboeuf, M., Ginhoux, F., Ochando, J. C., Kunisaki, Y., van Rooijen, N., Liu, C., Teshima, T., Heeger, P. S., Stanley, E. R., Frenette, P. S. & Merad, M., 5 1 2011, : : Journal of Experimental Medicine. 208, 5, p. 1069-1082 14 p.

研究成果: ジャーナルへの寄稿記事

Macrophage Colony-Stimulating Factor
Cell Transplantation
Graft vs Host Disease
Macrophages
T-Lymphocytes
2007
7 引用 (Scopus)

Successful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling

Nonami, A., Miyamoto, T., Kuroiwa, M., Kunisaki, Y., Kamezaki, K., Takenaka, K., Harada, N., Teshima, T., Harada, M. & Nagafuji, K., 12 1 2007, : : Japanese journal of clinical oncology. 37, 12, p. 969-972 4 p.

研究成果: ジャーナルへの寄稿記事

Plasma Cell Leukemia
Stem Cell Transplantation
Siblings
Hematopoietic Stem Cell Transplantation
HLA Antigens
47 引用 (Scopus)

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2

Tanaka, Y., Hamano, S., Gotoh, K., Murata, Y., Kunisaki, Y., Nishikimi, A., Takii, R., Kawaguchi, M., Inayoshi, A., Masuko, S., Himeno, K., Sasazuki, T. & Fukui, Y., 10 1 2007, : : Nature Immunology. 8, 10, p. 1067-1075 9 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4 Receptors
T-Cell Antigen Receptor
T-Lymphocytes
Down-Regulation
Stathmin
35 引用 (Scopus)

Toxoplasmosis encephalitis following severe graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation: 17 Yr experience in Fukuoka BMT group

Matsuo, Y., Takeishi, S., Miyamoto, T., Nonami, A., Kikushige, Y., Kunisaki, Y., Kamezaki, K., Tu, L., Hisaeda, H., Takenaka, K., Harada, N., Kamimura, T., Ohno, Y., Eto, T., Teshima, T., Gondo, H., Harada, M. & Nagafuji, K., 10 1 2007, : : European Journal of Haematology. 79, 4, p. 317-321 5 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cell Transplantation
Toxoplasmosis
Encephalitis
Transplants
Polymerase Chain Reaction
2006
143 引用 (Scopus)

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Kunisaki, Y., Nishikimi, A., Tanaka, Y., Takii, R., Noda, M., Inayoshi, A., Watanabe, K. I., Sanematsu, F., Sasazuki, T., Sasaki, T. & Fukui, Y., 8 28 2006, : : Journal of Cell Biology. 174, 5, p. 647-652 6 p.

研究成果: ジャーナルへの寄稿記事

Chemotaxis
Neutrophils
Chemotactic Factors
Phosphatidylinositol 3-Kinase
Formyl Peptide Receptor
25 引用 (Scopus)

DOCK2 is required in T cell precursors for development of Vα14 NK T cells

Kunisaki, Y., Tanaka, Y., Sanui, T., Inayoshi, A., Noda, M., Nakayama, T., Harada, M., Taniguchi, M., Sasazuki, T. & Fukui, Y., 4 15 2006, : : Journal of Immunology. 176, 8, p. 4640-4645 6 p.

研究成果: ジャーナルへの寄稿記事

T-Lymphoid Precursor Cells
Natural Killer T-Cells
Natural Killer Cells
T-Lymphocytes
Thymus Gland
2005
27 引用 (Scopus)

Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Jiang, H., Pan, F., Erickson, L. M., Jang, M. S., Sanui, T., Kunisaki, Y., Sasazuki, T., Kobayashi, M. & Fukui, Y., 10 17 2005, : : Journal of Experimental Medicine. 202, 8, p. 1121-1130 10 p.

研究成果: ジャーナルへの寄稿記事

Actin Cytoskeleton
Allografts
Lymphocytes
T-Lymphocytes
Immunological Synapses
2004
87 引用 (Scopus)

Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

Kunisaki, Y., Masuko, S., Noda, M., Inayoshi, A., Sanui, T., Harada, M., Sasazuki, T. & Fukui, Y., 5 1 2004, : : Blood. 103, 9, p. 3362-3364 3 p.

研究成果: ジャーナルへの寄稿記事

Lymphopoiesis
Erythropoiesis
Liver
Cells
Thymus
186 引用 (Scopus)

Differential requirements for DOCK2 and phosphoinositide-3-kinase γ during T and B lymphocyte homing

Nombela-Arrieta, C., Lacalle, R. A., Montoya, M. C., Kunisaki, Y., Megías, D., Marqués, M., Carrera, A. C., Mañes, S., Fukui, Y., Martínez-A, C. & Stein, J. V., 9 1 2004, : : Immunity. 21, 3, p. 429-441 13 p.

研究成果: ジャーナルへの寄稿記事

1-Phosphatidylinositol 4-Kinase
B-Lymphocytes
T-Lymphocytes
Integrins
Lymphocytes

Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation

Koyama, M., Matsuoka, K. I., Kunisaki, Y., Takeuchi, M. & Matsue, K., 1 1 2004, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 45, 10, p. 1115-1118 4 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Transplantation
Graft vs Host Disease
Hypercholesterolemia
Liver Diseases
Ursodeoxycholic Acid
2003
4 引用 (Scopus)
Marginal Zone B-Cell Lymphoma
Pleural Effusion
Population
Gastric Mucosa
B-Lymphocytes
20 引用 (Scopus)

Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6

Kunisaki, Y., Goto, H., Kitagawa, K. & Nagano, M., 2 1 2003, : : Internal Medicine. 42, 2, p. 203-207 5 p.

研究成果: ジャーナルへの寄稿記事

Human Herpesvirus 6
Sulfasalazine
Hypersensitivity
Viruses
Immunoglobulin G