α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds

Toshinori Nakagawa, Ahmed Ashour, Yhiya Amen, Yurie Koba, Koichiro Ohnuki, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

抄録

This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree (Abies sachalinensis). The resin showed extremely high activity (IC50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds-(holophyllane C (1), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4-seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−)-abiesonic acid 3-methyl ester (6))-showed high activity (their IC50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin's α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods.

元の言語英語
ジャーナルNatural product communications
14
発行部数6
DOI
出版物ステータス出版済み - 1 1 2019

Fingerprint

Abies sachalinensis
Glucosidases
Abies
glucosidases
resins
Acids
acids
Inhibitory Concentration 50
inhibitory concentration 50
Functional Food
health foods
Esters
in vitro studies
functional foods
bioactive compounds
esters
Health
assays

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

これを引用

α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds. / Nakagawa, Toshinori; Ashour, Ahmed; Amen, Yhiya; Koba, Yurie; Ohnuki, Koichiro; Shimizu, Kuniyoshi.

:: Natural product communications, 巻 14, 番号 6, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Nakagawa, Toshinori ; Ashour, Ahmed ; Amen, Yhiya ; Koba, Yurie ; Ohnuki, Koichiro ; Shimizu, Kuniyoshi. / α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds. :: Natural product communications. 2019 ; 巻 14, 番号 6.
@article{25c885c3509c4da582cdcbe8dee83b39,
title = "α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds",
abstract = "This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree (Abies sachalinensis). The resin showed extremely high activity (IC50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds-(holophyllane C (1), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4-seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−)-abiesonic acid 3-methyl ester (6))-showed high activity (their IC50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin's α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods.",
author = "Toshinori Nakagawa and Ahmed Ashour and Yhiya Amen and Yurie Koba and Koichiro Ohnuki and Kuniyoshi Shimizu",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/1934578X19858460",
language = "English",
volume = "14",
journal = "Natural Product Communications",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "6",

}

TY - JOUR

T1 - α-Glucosidase inhibitory activity of resin from sakhalin fir tree (abies sachalinensis) and its bioactive compounds

AU - Nakagawa, Toshinori

AU - Ashour, Ahmed

AU - Amen, Yhiya

AU - Koba, Yurie

AU - Ohnuki, Koichiro

AU - Shimizu, Kuniyoshi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree (Abies sachalinensis). The resin showed extremely high activity (IC50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds-(holophyllane C (1), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4-seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−)-abiesonic acid 3-methyl ester (6))-showed high activity (their IC50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin's α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods.

AB - This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree (Abies sachalinensis). The resin showed extremely high activity (IC50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds-(holophyllane C (1), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid (2), abiesonic acid (3), (−)-(24E)-23-oxo-3,4-seco-9βH-lanosta-4(28),7,24-triene-3,26-dioic acid (4), 3,4-seco-4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid (5), and (−)-abiesonic acid 3-methyl ester (6))-showed high activity (their IC50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin's α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new data to support that the resin of A. sachalinensis is a rich source of α-glucosidase inhibitors, which are highly valuable for their potential to be developed as functional health foods.

UR - http://www.scopus.com/inward/record.url?scp=85068613554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068613554&partnerID=8YFLogxK

U2 - 10.1177/1934578X19858460

DO - 10.1177/1934578X19858460

M3 - Article

VL - 14

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 6

ER -