α-helical polypeptide microcapsules formed by emulsion-templated self-assembly

Masa Aki Morikawa, Masakuni Yoshihara, Takeshi Endo, Nobuo Kimizuka

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

抜粋

α-Helical peptide microcapsules were prepared by the emulsion-templated self-assembly of amphiphilic poly(γ-benzyl L-glutamate)s (PBLG) 1. By mixing solutions of 1 in dichloromethane (in the form of a sodium salt) with water, oil-in-water emulsions were obtained. Spontaneous stripping of the dichloromethane phase caused a decrease in the diameter of the microdroplets and finally stable microcapsules formed. The microcapsules contain an inner aqueous phase as observed by confocal laser scanning microscopy (CLSM). Binding of hydrophobic pyrene molecules to the polypeptide shell was also demonstrated. The present polypeptide microcapsules are stable even after drying in air and they would serve as supramolecular vehicles for both hydrophobic and water-soluble molecules.

元の言語英語
ページ(範囲)1574-1578
ページ数5
ジャーナルChemistry - A European Journal
11
発行部数5
DOI
出版物ステータス出版済み - 2 18 2005

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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