αB-Crystallin in C6 glioma cells supports their survival in elevated extracellular K+: the implication of a protective role of αB-crystallin accumulation in reactive glia

Toru Iwaki, Akiko Iwaki, Yasuyuki Fukumaki, Jun Tateishi

研究成果: Contribution to journalArticle査読

42 被引用数 (Scopus)

抄録

It has been shown by immunohistochemical studies that αB-crystallin accumulates in the reactive and neoplastic glial cells in a variety of pathologic situations. However, the molecular mechanism for the induction of αB-crystallin in diseased brains is still unknown. Since any destructive brain lesions cause an abnormal elevation in the potassium (K+) concentration of the extracellular space, which disturbs the regulatory mechanism of glial cell volume, we investigated the influence of elevated extracellular K+ on the expression of αB-crystallin in glial cells. The treatment of rat C6 glioma cells with augmented K+ in the culture media induced an accumulation of αB-crystallin mRNA in a dose-dependent manner and an accumulation of the αB-crystallin as well. Furthermore, an overexpression of αB-crystallin in the C6 transformant transfected with a rat αB-crystallin cDNA conferred a resistant phenotype against the insult of elevated extracellular K+ on the glioma cells. Thus, αB-crystallin may contribute to the survival of reactive glia in the presence of a high extracellular K+ concentration.

本文言語英語
ページ(範囲)47-52
ページ数6
ジャーナルBrain Research
673
1
DOI
出版ステータス出版済み - 2 27 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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