β-1,3-glucan polysaccharides as novel one-dimensional hosts for DNA/RNA, conjugated polymers and nanoparticles

Kazuo Sakurai, Kazuya Uezu, Munenori Numata, Teruaki Hasegawa, Chun Li, Kenji Kaneko, Seiji Shinkai

研究成果: Contribution to journalArticle査読

115 被引用数 (Scopus)

抄録

β-1,3-Glucan polysaccharides have triple-stranded helical structures whose sense and pitch are comparable to those of polynucleotides. We recently revealed that the β-1,3-glucans could interact with certain polynucleotides to form triple-stranded and helical macromolecular complexes consisting of two polysaccharide-strands and one polynucleotide-strand. This unique property of the β-1,3-glucans has made it possible to utilize these polysaccharides as potential carriers for various functional polynucleotides. In paticular, cell-uptake efficiency of the resultant polysaccharide/polynucleotide complexes was remarkably enhanced when functional groups recognized in a biological system were introduced as pendent groups. The β-1,3-glucans can also interact with various one-dimensional architectures, such as single-walled carbon nanotubes, to produce unique nanocomposites, in which the single-walled carbon nanotubes are entrapped within the helical superstructure of β-1,3-glucans. Various conductive polymers and gold nanoparticles are also entrapped within the helical superstructure in a similar manner. In addition, diacetylene monomers entrapped within the helical superstructure can be photopolymerized to afford the corresponding poly(diacetylene)-nanofibers with a uniform diameter. These findings indicate that the β-1,3-glucans are very attractive and useful materials not only in biotechnology but also in nanotechnology. These unique properties of the β-1,3-glucans undoubtedly originate from their inherent, very strong helix-forming character which has never been observed for other polysaccharides.

本文言語英語
ページ(範囲)4383-4398
ページ数16
ジャーナルChemical Communications
35
DOI
出版ステータス出版済み - 9 21 2005

All Science Journal Classification (ASJC) codes

  • 触媒
  • 電子材料、光学材料、および磁性材料
  • セラミックおよび複合材料
  • 化学 (全般)
  • 表面、皮膜および薄膜
  • 金属および合金
  • 材料化学

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