β-Adrenergic receptor and insulin resistance in the heart

Supachoke Mangmool, Tananat Denkaew, Warisara Parichatikanond, Hitoshi Kurose

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

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Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Overstimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR overstimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs overstimulation leads to induction of insulin resistance in the heart.

元の言語英語
ページ(範囲)44-56
ページ数13
ジャーナルBiomolecules and Therapeutics
25
発行部数1
DOI
出版物ステータス出版済み - 1 2017

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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