β-Adrenergic receptor and insulin resistance in the heart

Supachoke Mangmool, Tananat Denkaew, Warisara Parichatikanond, Hitoshi Kurose

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Overstimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR overstimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs overstimulation leads to induction of insulin resistance in the heart.

本文言語英語
ページ(範囲)44-56
ページ数13
ジャーナルBiomolecules and Therapeutics
25
1
DOI
出版ステータス出版済み - 1 2017

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 薬理学
  • 創薬

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