β-arrestin-mediated signaling improves the efficacy of therapeutics

Islam A.A.E.H. Ibrahim, Hitoshi Kurose

研究成果: ジャーナルへの寄稿評論記事

20 引用 (Scopus)

抜粋

β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G protein activation. The diversity of these signaling pathways has also been recognized. This leads to an appreciation of β-arrestin-biased agonists, which is a new class of drugs that selectively activate β-arrestin-mediated signaling without G protein activation. In this review, we will discuss the recent advance of β-arrestin-mediated signaling pathways, including a brief account of different biased agonists, their pharmacological applications, and novel β-arrestin research.

元の言語英語
ページ(範囲)408-412
ページ数5
ジャーナルJournal of Pharmacological Sciences
118
発行部数4
DOI
出版物ステータス出版済み - 10 12 2012

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用