γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis

L. Monin, D. S. Ushakov, H. Arnesen, N. Bah, A. Jandke, M. Muñoz-Ruiz, J. Carvalho, S. Joseph, B. C. Almeida, M. J. Green, E. Nye, S. Hatano, Y. Yoshikai, M. Curtis, H. Carlsen, U. Steinhoff, P. Boysen, A. Hayday

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier reports, most cells expressed a canonical Vγ6Vδ1 TCR, and produced interleukin (IL)-17A upon stimulation. Nonetheless, contrasting with earlier reports, uterine γδ T cells were not obviously intraepithelial, being more akin to sub-epithelial Vγ6Vδ1+ T cells at several other anatomical sites. By contrast to other tissues however, the uterine compartment also included non-Vγ6+, IFN-γ-producing cells; was strikingly enriched in young mice; expressed genes hitherto associated with the uterus, including the progesterone receptor; and did not require microbes for development and/or maintenance. This notwithstanding, γδ T-cell deficiency severely impaired resistance to reproductive tract infection by Candida albicans, associated with decreased responses of IL-17-dependent neutrophils. These findings emphasise tissue-specific complexities of different mucosal γδ cell compartments, and their evident importance in lymphoid stress-surveillance against barrier infection.

本文言語英語
ページ(範囲)969-981
ページ数13
ジャーナルMucosal Immunology
13
6
DOI
出版ステータス出版済み - 11 1 2020

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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