Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai; Hisashi Ohta; Takao Shimazoe; Yasufumi Kataoka; Michihiro Fujiwara; Showa Ueki

doi:10.1016/0024-3205(85)90569-7

Δ⁹-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai, Hisashi Ohta, Takao Shimazoe, Yasufumi Kataoka, Michihiro Fujiwara, Showa Ueki

臨床薬学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

23 被引用数 (Scopus)

抄録

The present study was designed to examine the influence of Δ⁹-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

本文言語	英語
ページ（範囲）	2181-2185
ページ数	5
ジャーナル	Life Sciences
巻	37
号	23
DOI	https://doi.org/10.1016/0024-3205(85)90569-7
出版ステータス	出版済み - 12月 9 1985

!!!All Science Journal Classification (ASJC) codes

生化学、遺伝学、分子生物学（全般）
薬理学、毒性学および薬学（全般）

文献へのアクセス

10.1016/0024-3205(85)90569-7

他のファイルとリンク

引用スタイル

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title = "Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion",

abstract = "The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.",

author = "Yasuko Sakurai and Hisashi Ohta and Takao Shimazoe and Yasufumi Kataoka and Michihiro Fujiwara and Showa Ueki",

note = "Funding Information: This study was partly supported by Grant-in-Aid for Scientific Research from Japanese Ministry of Education, and Culture.",

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T1 - Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

AU - Sakurai, Yasuko

AU - Ohta, Hisashi

AU - Shimazoe, Takao

AU - Kataoka, Yasufumi

AU - Fujiwara, Michihiro

AU - Ueki, Showa

N1 - Funding Information: This study was partly supported by Grant-in-Aid for Scientific Research from Japanese Ministry of Education, and Culture.

PY - 1985/12/9

Y1 - 1985/12/9

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AB - The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

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