Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion

Yasuko Sakurai, Hisashi Ohta, Takao Shimazoe, Yasufumi Kataoka, Michihiro Fujiwara, Showa Ueki

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

The present study was designed to examine the influence of Δ9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxydopamine. THC-induced ispilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.

元の言語英語
ページ(範囲)2181-2185
ページ数5
ジャーナルLife Sciences
37
発行部数23
DOI
出版物ステータス出版済み - 12 9 1985

Fingerprint

Dronabinol
Substantia Nigra
Rats
Oxidopamine
Dopaminergic Neurons
Haloperidol
Neurons

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion. / Sakurai, Yasuko; Ohta, Hisashi; Shimazoe, Takao; Kataoka, Yasufumi; Fujiwara, Michihiro; Ueki, Showa.

:: Life Sciences, 巻 37, 番号 23, 09.12.1985, p. 2181-2185.

研究成果: ジャーナルへの寄稿記事

Sakurai, Yasuko ; Ohta, Hisashi ; Shimazoe, Takao ; Kataoka, Yasufumi ; Fujiwara, Michihiro ; Ueki, Showa. / Δ9-tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion. :: Life Sciences. 1985 ; 巻 37, 番号 23. pp. 2181-2185.
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