Δ9-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: Involvement of cannabinoid CB1 receptor and serotonergic system

Nobuaki Egashira, Tomomi Matsuda, Emi Koushi, Fuminori Higashihara, Kenichi Mishima, Shozo Chidori, Nobuyoshi Hasebe, Katsunori Iwasaki, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

In the present study, we investigated the effect of Δ9-tetrahydrocannabinol (THC), the principal psychoactive component of marijuana, on immobility time during the forced swim test. THC (2 and 6 mg/kg, i.p.) significantly prolonged the immobility time. In addition, THC at the same doses did not significantly affect locomotor activity in the open-field test. The selective cannabinoid CB1 receptor antagonist rimonabant (3 mg/kg, i.p.) significantly reduced the enhancement of immobility by THC (6 mg/kg). Similarly, the selective serotonin (5-HT) reuptake inhibitor (SSRI) citalopram (10 mg/kg, i.p.) and 5-HT1A/7 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.3 mg/kg, i.p.) significantly reduced this THC-induced effect. Moreover, the selective 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide dihydrochloride (WAY100635, 1 mg/kg, i.p.) and the postsynaptic 5-HT1A receptor antagonist MM-77 (0.1 mg/kg, i.p.) reversed this reduction effect of 8-OH-DPAT (0.3 mg/kg). In contrast, the selective 5-HT7 receptor antagonist (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) had no effect on this reduction effect of 8-OH-DPAT. WAY100635 (1 mg/kg) also reversed the reduction effect of citalopram (10 mg/kg). These findings suggest that the 5-HT1A receptors are involved in THC-induced enhancement of immobility.

本文言語英語
ページ(範囲)117-121
ページ数5
ジャーナルEuropean Journal of Pharmacology
589
1-3
DOI
出版ステータス出版済み - 7 28 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology

フィンガープリント 「Δ<sup>9</sup>-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: Involvement of cannabinoid CB<sub>1</sub> receptor and serotonergic system」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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