抄録
We determined the effect of 1-hexylcarbamoyl-5-fluorouracil (HCFU), a masked compound of 5-fluorouracil, on the expression of heat shock protein (HSP) in heat-treated HeLa cells. We used a monoclonal anti-72-kDa heat shock protein antibody. At 37 degrees C, HSP was predominant in the cytoplasm of cells and heating to 43 degrees C for 30 min increased the synthesis of HSP in the nucleus. When HeLa cells were treated with heat and HCFU, at a concentration which showed evidence of synergy, nuclear staining of the cells decreased. Thus, the altered expression of HSP by HCFU is related to a synergism between heat and HCFU.
本文言語 | 英語 |
---|---|
ページ(範囲) | 45-48 |
ページ数 | 4 |
ジャーナル | Anti-cancer drugs |
巻 | 2 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 2月 1991 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 腫瘍学
- 薬理学
- 薬理学(医学)
- 癌研究