1-methyl-4-phenylpyridinium (MPP+) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells

E. Hasegawa, H. Asagami, D. Kang, S. Minakami, K. Takeshige

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

When rat pheochromocytoma PC12 cells are cultured with 1 mM 1-methyl-4-phenylpyridinium (MPP+), the number of viable cells decreases to one third in 4 days while the number increases ten-fold without MPP+. Oxygen consumption by mitochondria in the presence of malate is inhibited about 80% by the treatment of the cells with MPP+ for 4 days. Unexpectedly, succinate-dependent oxygen consumption is also inhibited to essentially the same extent as malate-dependent one. These results suggest that the impairment of the respiration mediated by succinate as well as malate is important as a mechanism of MPP+-induced cell death.

本文言語英語
ページ(範囲)409-413
ページ数5
ジャーナルBiochemistry and Molecular Biology International
35
2
出版ステータス出版済み - 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

フィンガープリント 「1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) inhibits mitochondrial oxygen consumption mediated by succinate as well as malate in rat pheochromocytoma PC12 cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル