1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong; Masanori Inagaki; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Rob W.M. Van Soest

doi:10.1248/cpb.51.731

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W.M. Van Soest

生命薬学

研究成果: Contribution to journal › Article › 査読

14 被引用数 (Scopus)

抄録

An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

本文言語	英語
ページ（範囲）	731-733
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	51
号	6
DOI	https://doi.org/10.1248/cpb.51.731
出版ステータス	出版済み - 6 2003

All Science Journal Classification (ASJC) codes

化学 (全般)
創薬

文献へのアクセス

10.1248/cpb.51.731

他のファイルとリンク

引用スタイル

@article{48e2a357790f4855b133355e9126e880,

title = "1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis",

abstract = "An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.",

author = "Jeong, {Sei Joon} and Masanori Inagaki and Ryuichi Higuchi and Tomofumi Miyamoto and Mayumi Ono and Michihiko Kuwano and {Van Soest}, {Rob W.M.}",

year = "2003",

month = jun,

doi = "10.1248/cpb.51.731",

language = "English",

volume = "51",

pages = "731--733",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "The Pharmaceutical Society of Japan",

number = "6",

}

TY - JOUR

T1 - 1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

AU - Jeong, Sei Joon

AU - Inagaki, Masanori

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

AU - Ono, Mayumi

AU - Kuwano, Michihiko

AU - Van Soest, Rob W.M.

PY - 2003/6

Y1 - 2003/6

N2 - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

AB - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

UR - http://www.scopus.com/inward/record.url?scp=12344312135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344312135&partnerID=8YFLogxK

U2 - 10.1248/cpb.51.731

DO - 10.1248/cpb.51.731

M3 - Article

C2 - 12808256

AN - SCOPUS:12344312135

VL - 51

SP - 731

EP - 733

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 6

ER -

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

抄録

All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル