抄録
An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 731-733 |
| ページ数 | 3 |
| ジャーナル | Chemical and Pharmaceutical Bulletin |
| 巻 | 51 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | 出版済み - 6 2003 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Drug Discovery
これを引用
1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis. / Jeong, Sei Joon; Inagaki, Masanori; Higuchi, Ryuichi; Miyamoto, Tomofumi; Ono, Mayumi; Kuwano, Michihiko; Van Soest, Rob W.M.
：: Chemical and Pharmaceutical Bulletin, 巻 51, 番号 6, 06.2003, p. 731-733.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - 1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis
AU - Jeong, Sei Joon
AU - Inagaki, Masanori
AU - Higuchi, Ryuichi
AU - Miyamoto, Tomofumi
AU - Ono, Mayumi
AU - Kuwano, Michihiko
AU - Van Soest, Rob W.M.
PY - 2003/6
Y1 - 2003/6
N2 - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
AB - An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
UR - http://www.scopus.com/inward/record.url?scp=12344312135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12344312135&partnerID=8YFLogxK
U2 - 10.1248/cpb.51.731
DO - 10.1248/cpb.51.731
M3 - Article
C2 - 12808256
AN - SCOPUS:12344312135
VL - 51
SP - 731
EP - 733
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 6
ER -