1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W.M. Van Soest

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

元の言語英語
ページ(範囲)731-733
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
51
発行部数6
DOI
出版物ステータス出版済み - 6 2003

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Endothelial cells
Porifera
Aorta
Endothelial Cells
Fibroblast Growth Factor 2
Ethanol
X-Rays
X rays
purine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis. / Jeong, Sei Joon; Inagaki, Masanori; Higuchi, Ryuichi; Miyamoto, Tomofumi; Ono, Mayumi; Kuwano, Michihiko; Van Soest, Rob W.M.

:: Chemical and Pharmaceutical Bulletin, 巻 51, 番号 6, 06.2003, p. 731-733.

研究成果: ジャーナルへの寄稿記事

Jeong, Sei Joon ; Inagaki, Masanori ; Higuchi, Ryuichi ; Miyamoto, Tomofumi ; Ono, Mayumi ; Kuwano, Michihiko ; Van Soest, Rob W.M. / 1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis. :: Chemical and Pharmaceutical Bulletin. 2003 ; 巻 51, 番号 6. pp. 731-733.
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AU - Van Soest, Rob W.M.

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