1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong; Masanori Inagaki; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Rob W.M. Van Soest

doi:10.1248/cpb.51.731

1,3-Dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis

Sei Joon Jeong, Masanori Inagaki, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Rob W.M. Van Soest

生命薬学

研究成果: Contribution to journal › Article › 査読

13 被引用数 (Scopus)

抄録

An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.

本文言語	英語
ページ（範囲）	731-733
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	51
号	6
DOI	https://doi.org/10.1248/cpb.51.731
出版ステータス	出版済み - 6 2003

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

文献へのアクセス

10.1248/cpb.51.731

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引用スタイル

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AU - Ono, Mayumi

AU - Kuwano, Michihiko

AU - Van Soest, Rob W.M.

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