抄録
An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
本文言語 | 英語 |
---|---|
ページ(範囲) | 731-733 |
ページ数 | 3 |
ジャーナル | Chemical and Pharmaceutical Bulletin |
巻 | 51 |
号 | 6 |
DOI | |
出版ステータス | 出版済み - 6月 2003 |
!!!All Science Journal Classification (ASJC) codes
- 化学 (全般)
- 創薬