抄録
We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 149-150 |
| ページ数 | 2 |
| ジャーナル | Nucleic acids research. Supplement (2001) |
| 発行部数 | 2 |
| 出版物ステータス | 出版済み - 1 1 2002 |
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2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides. / Ali, Md Monsur; Nagatsugi, Fumi; Yamamoto, Fumihiko; Maeda, Minoru; Sasaki, Shigeki.
：: Nucleic acids research. Supplement (2001), 番号 2, 01.01.2002, p. 149-150.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - 2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.
AU - Ali, Md Monsur
AU - Nagatsugi, Fumi
AU - Yamamoto, Fumihiko
AU - Maeda, Minoru
AU - Sasaki, Shigeki
PY - 2002/1/1
Y1 - 2002/1/1
N2 - We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.
AB - We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.
UR - http://www.scopus.com/inward/record.url?scp=0041317456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041317456&partnerID=8YFLogxK
M3 - Article
C2 - 12903149
AN - SCOPUS:0041317456
SP - 149
EP - 150
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 2
ER -