2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides.

Md Monsur Ali, Fumi Nagatsugi, Fumihiko Yamamoto, Minoru Maeda, Shigeki Sasaki

研究成果: ジャーナルへの寄稿記事

抄録

We have previously demonstrated that 2-amino-6-vinylpurine is an efficient cross-linking agent with high selectivity towards cytidine. In this study, we applied this nucleobase analog to versatile conjugation of oligodeoxynucleotides with radio-, spin-, fluorescence- and peptide labels. The oligodeoxynucleotides incorporating 2-amino-6-vinylpurine nucleoside were reacted with amino- bearing nucleophies in an excess amount to give the corresponding conjugates in good yield.

元の言語英語
ページ(範囲)149-150
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
発行部数2
出版物ステータス出版済み - 1 1 2002

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Spin Labels
Oligodeoxyribonucleotides
Radio
Fluorescence
Cytidine
Peptides
DNA
Nucleosides
2-amino-6-vinylpurine
purine

これを引用

2-Amino-6-vinyl purine as a tool for post synthetic conjugation of DNA with radio-, spin-, fluorescence labels and peptides. / Ali, Md Monsur; Nagatsugi, Fumi; Yamamoto, Fumihiko; Maeda, Minoru; Sasaki, Shigeki.

:: Nucleic acids research. Supplement (2001), 番号 2, 01.01.2002, p. 149-150.

研究成果: ジャーナルへの寄稿記事

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