2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives

Takahiro Shirai, Motomu Kanai, Yoichiro Kuninobu

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

We developed 2-position-selective, direct C-H trifluoromethylation, pentafluoroethylation, and heptafluoropropylation of quinoline derivatives. Regioselective transformation was achieved without derivatization of the quinolines. The reaction proceeded at room temperature with high functional group tolerance, even in gram scale. Notably, the reaction was applicable to substrates containing a functional group sensitive to oxidation and a drug molecule.

本文言語英語
ページ(範囲)1593-1596
ページ数4
ジャーナルOrganic letters
20
6
DOI
出版ステータス出版済み - 3 16 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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