抄録
The regioselective C-H trifluoromethylthiolation of six-membered heteroaromatic compounds via nucleophilic attack of a CF3S source on the electrophilically activated six-membered heteroaromatic ring was developed. The reaction proceeds in good yield with good functional group tolerance, even on a gram-scale. The key to the successful regioselective transformation is the presence of an additive (2,4-dinitrobenzenesulfonyl chloride). The regioselective trifluoromethylthiolation of quinidine derivative is also demonstrated. Trifluoromethylthiolation, followed by S-oxidation, affords the corresponding sulfones.
本文言語 | 英語 |
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ジャーナル | Organic letters |
DOI | |
出版ステータス | 出版済み - 1月 1 2019 |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 物理化学および理論化学
- 有機化学