20(R)-Ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity

Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Hongshan Yu, Chunzhi Zhang, Fengxie Jin, Ryuichiro Kondo

研究成果: Contribution to journalArticle査読

47 被引用数 (Scopus)

抄録

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. In this study, we investigated the inhibitory effects of ginsenosides (ginsenoside 20(R)-Rh2 and ginsenoside 20(S)-Rh2) on osteoclastgenesis using RAW264 cells in vitro. Only ginsenoside 20(R)-Rh2 showed selective osteoclastgenesis inhibitory activity without any cytotoxicity up to 100 μM. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in selective osteoclastgenesis inhibitory activity.

本文言語英語
ページ(範囲)3320-3323
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
19
12
DOI
出版ステータス出版済み - 6 15 2009

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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