20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng

Sri Fatmawati, Taslim Ersam, Hongshan Yu, Chunzhi Zhang, Fengxie Jin, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

The root of Panax ginseng C. A. Meyer (Araliaceae) is a well-known herbal medicine in East Asia. The major bioactive metabolites in this root are commonly identified as ginsenosides. A series of ginsenosides were determined for in vitro human recombinant aldose reductase. This Letter aims to clarify the structural requirement for aldose reductase inhibition. We discovered that only ginsenoside 20(S)-Rh2 showed potent against aldose reductase, with an IC50of 147.3 μM. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in aldose reductase inhibition. An understanding of these requirements is considered necessary in order to develop a new type of aldose reductase inhibitor. Furthermore, P. ginseng might be an important herbal medicine in preventing diabetic complications.

本文言語英語
ページ(範囲)4407-4409
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
24
18
DOI
出版ステータス出版済み - 9 15 2014

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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