3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

Shigeki Sasaki, Tohru Mizushima, Tomohiro Hashimoto, Minoru Maeda, Sekimizu Kazuhisa

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抜粋

3-Acetoxy-2,2′-bi-1H-indol which is derived from indigo was found to be a novel and potent inhibitor of ATP binding (IC50=0.04mM) to DnaA protein, a key protein in the initiation of chromosomal DNA replication in Escherichia coli. Competitive experiments indicated the inhibition to be non-competitive with ATP.

元の言語英語
ページ(範囲)1771-1774
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
4
発行部数14
DOI
出版物ステータス出版済み - 7 21 1994

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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