3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

Ryohei Yonesaki, Yuta Kondo, Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

Although BINOL-derived phosphoric acids are among the most widely used chiral Brønsted acid organocatalysts, their structures are mostly limited to 3,3′-disubstituted ones and simple 3-mono-substituted ones without any polar functionalities on the 3-substituent have not been used in highly enantioselective reactions. This work reports such 3-mono-substituted analogues as effective organocatalysts in direct highly enantioselective Friedel–Crafts-type alkylation of N-unprotected α-ketiminoester. The origin of the observed high enantioselectivity with the 3-mono-substituted catalyst is also discussed.

本文言語英語
ページ(範囲)15211-15214
ページ数4
ジャーナルChemistry - A European Journal
24
57
DOI
出版ステータス出版済み - 10 12 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

フィンガープリント 「3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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