In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC 50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 μM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC 50 of 1 was 56.7 μM with less cytotoxicity.
All Science Journal Classification (ASJC) codes
- Drug Discovery