3D structures of membrane-associated small molecules as determined in isotropic bicelles

Nobuaki Matsumori, Michio Murata

研究成果: Contribution to journalReview article査読

21 被引用数 (Scopus)

抄録

About half of known bioactive organic molecules, including drugs, are known to target biological membranes and membrane proteins. Despite this, it has proven difficult to define the membrane-bound conformations of these molecules. In recent years, bicelles have been recognized as a more appropriate membrane model than micelles because their planar portion is composed of a lipid bilayer. Bicelles with a small diameter, termed isotropic or fast-tumbling bicelles, allow for high-resolution NMR measurements due to their high mobility in suspension, and therefore have become a versatile tool for structure studies of membrane-associated molecules. Following a brief description of the morphology and preparation of isotropic bicelles, we summarize their application to structural studies of membrane-bound peptides and small molecules, and then highlight our recent studies on the 3D structures of erythromycin A, salinomycin and amphidinol 3 using isotropic bicelles.

本文言語英語
ページ(範囲)1480-1492
ページ数13
ジャーナルNatural Product Reports
27
10
DOI
出版ステータス出版済み - 10 1 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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