5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Jie Liu; Kenji Kurashiki; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1248/bpb.29.392

5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

50 被引用数 (Scopus)

抄録

5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC₅₀ of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

本文言語	英語
ページ（範囲）	392-395
ページ数	4
ジャーナル	Biological and Pharmaceutical Bulletin
巻	29
号	2
DOI	https://doi.org/10.1248/bpb.29.392
出版ステータス	出版済み - 2月 2006

!!!All Science Journal Classification (ASJC) codes

薬理学
薬科学

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title = "5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum",

abstract = "5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC50 of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.",

author = "Jie Liu and Kenji Kurashiki and Kuniyoshi Shimizu and Ryuichiro Kondo",

year = "2006",

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doi = "10.1248/bpb.29.392",

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T1 - 5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

AU - Liu, Jie

AU - Kurashiki, Kenji

AU - Shimizu, Kuniyoshi

AU - Kondo, Ryuichiro

PY - 2006/2

Y1 - 2006/2

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AB - 5α-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5α-lanosta-7,9(11),24-triene-15α,26-dihydroxy-3-one with an IC50 of 10.6 μM and 41.9 μM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

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5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum

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!!!All Science Journal Classification (ASJC) codes

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