5-Aryl-1,3,4-oxadiazole-2-thiols as a new series of trans-cinnamate 4-hydroxylase inhibitors

Naotaka Yamada, Yuki Kataoka, Takamichi Nagami, Soonsung Hong, Shinya Kawai, Eiichi Kuwano

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

A series of 5-aryl-1,3,4-oxadiazole-2-thiols was found to inhibit trans-cinnamate 4-hydroxylase (C4H) from Populus kitakamiensis, which was expressed in yeast. 5-Phenyl-1,3,4-oxadiazole-2-thiol showed inhibitory activity comparable to 2-hydroxy-1-naphthoic acid, a known C4H inhibitor. Studies on the structure-activity relationship indicated that the presence of a thiol group was significant for stronger activity. Of the compounds tested, 5-(3-fluorophenyl)-1,3,4-oxadiazole-2-thiol was the most active.

本文言語英語
ページ(範囲)205-208
ページ数4
ジャーナルJournal of Pesticide Science
29
3
DOI
出版ステータス出版済み - 2004

All Science Journal Classification (ASJC) codes

  • Insect Science
  • Health, Toxicology and Mutagenesis

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