5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

Toshihide Kuroki, Herbert Y. Meltzer, Junji Ichikawa

研究成果: Contribution to journalArticle査読

51 被引用数 (Scopus)

抄録

(±)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.

本文言語英語
ページ(範囲)216-221
ページ数6
ジャーナルBrain Research
972
1-2
DOI
出版ステータス出版済み - 5 16 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

フィンガープリント 「5-HT<sub>2A</sub> receptor stimulation by DOI, a 5-HT<sub>2A/2C</sub> receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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