6-Amino-6-deoxychitosan was prepared from 6-deoxy-6-halo-N- phthaloylchitosan via 6-azidation. The product has high stereoregularity because of the effective and regioselective reactions. To evaluate 6-amino-6- deoxychitosan as a gene transfer agent, transfection efficiencies of its complexes with plasmid DNA in COS-1 cells were examined.
All Science Journal Classification (ASJC) codes
- 化学 (全般)