抜粋
A structure-activity relationship (SAR) study of kaitocephalin (KCP), known to be a potent naturally occurring NMDA receptor ligand, was performed. This study led us to the discovery of (7S)-kaitocephalin as a highly selective NMDA receptor ligand. It displayed a 22-fold higher degree of selectivity for the NMDA receptor over KCP, though the binding affinity of (7S)-KCP [Ki = 29 nM] was 3.7-fold less potent than that of KCP [Ki = 7.8 nM].
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 1206-1210 |
| ページ数 | 5 |
| ジャーナル | Organic and Biomolecular Chemistry |
| 巻 | 14 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2016 |
| 外部発表 | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
フィンガープリント (7S)-Kaitocephalin as a potent NMDA receptor selective ligand' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Yasuno, Y., Hamada, M., Kawasaki, M., Shimamoto, K., Shigeri, Y., Akizawa, T., Konishi, M., Ohfune, Y., & Shinada, T. (2016). (7S)-Kaitocephalin as a potent NMDA receptor selective ligand. Organic and Biomolecular Chemistry, 14(4), 1206-1210. https://doi.org/10.1039/c5ob02301g