@article{99a4d03c16a24ef985893061872bbf8b,
title = "(7S)-Kaitocephalin as a potent NMDA receptor selective ligand",
abstract = "A structure-activity relationship (SAR) study of kaitocephalin (KCP), known to be a potent naturally occurring NMDA receptor ligand, was performed. This study led us to the discovery of (7S)-kaitocephalin as a highly selective NMDA receptor ligand. It displayed a 22-fold higher degree of selectivity for the NMDA receptor over KCP, though the binding affinity of (7S)-KCP [Ki = 29 nM] was 3.7-fold less potent than that of KCP [Ki = 7.8 nM].",
author = "Yoko Yasuno and Makoto Hamada and Masanori Kawasaki and Keiko Shimamoto and Yasushi Shigeri and Toshifumi Akizawa and Motomi Konishi and Yasufumi Ohfune and Tetsuro Shinada",
note = "Funding Information: TS gratefully acknowledges financial support from Scientific Research of Innovative Areas, Chemical Biology of Natural Products, the Ministry of Education, Culture, Sports, Science and Technology (No. 23102009) and the Japan Society for the Promotion of Science (KAKENHI No. 23228001, 25282233). YY gratefully acknowledges financial support by the Sasagawa Scientific Research Grant from The Japan Science Society.",
year = "2016",
doi = "10.1039/c5ob02301g",
language = "English",
volume = "14",
pages = "1206--1210",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "4",
}