8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis

Keishi Sugimachi, Rui Yamaguchi, Hidetoshi Eguchi, Masami Ueda, Atsushi Niida, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yoshiaki Shinden, Tomohiro Iguchi, Kazutoyo Morita, Ken Yamamoto, Satoru Miyano, Masaki Mori, Yoshihiko Maehara, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

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Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

元の言語英語
ページ(範囲)546-551
ページ数6
ジャーナルAnnals of Surgical Oncology
23
DOI
出版物ステータス出版済み - 8 1 2016

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Diabetes Mellitus
Carcinogenesis
Single Nucleotide Polymorphism
Colorectal Neoplasms
Lipid Metabolism
Meta-Analysis
Genes
Oligonucleotide Array Sequence Analysis
Comorbidity
Multivariate Analysis
Alleles
Morbidity
apolipoprotein A-IV

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. / Sugimachi, Keishi; Yamaguchi, Rui; Eguchi, Hidetoshi; Ueda, Masami; Niida, Atsushi; Sakimura, Shotaro; Hirata, Hidenari; Uchi, Ryutaro; Shinden, Yoshiaki; Iguchi, Tomohiro; Morita, Kazutoyo; Yamamoto, Ken; Miyano, Satoru; Mori, Masaki; Maehara, Yoshihiko; Mimori, Koshi.

:: Annals of Surgical Oncology, 巻 23, 01.08.2016, p. 546-551.

研究成果: ジャーナルへの寄稿記事

Sugimachi, K, Yamaguchi, R, Eguchi, H, Ueda, M, Niida, A, Sakimura, S, Hirata, H, Uchi, R, Shinden, Y, Iguchi, T, Morita, K, Yamamoto, K, Miyano, S, Mori, M, Maehara, Y & Mimori, K 2016, '8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis', Annals of Surgical Oncology, 巻. 23, pp. 546-551. https://doi.org/10.1245/s10434-016-5374-1
Sugimachi, Keishi ; Yamaguchi, Rui ; Eguchi, Hidetoshi ; Ueda, Masami ; Niida, Atsushi ; Sakimura, Shotaro ; Hirata, Hidenari ; Uchi, Ryutaro ; Shinden, Yoshiaki ; Iguchi, Tomohiro ; Morita, Kazutoyo ; Yamamoto, Ken ; Miyano, Satoru ; Mori, Masaki ; Maehara, Yoshihiko ; Mimori, Koshi. / 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis. :: Annals of Surgical Oncology. 2016 ; 巻 23. pp. 546-551.
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AU - Sugimachi, Keishi

AU - Yamaguchi, Rui

AU - Eguchi, Hidetoshi

AU - Ueda, Masami

AU - Niida, Atsushi

AU - Sakimura, Shotaro

AU - Hirata, Hidenari

AU - Uchi, Ryutaro

AU - Shinden, Yoshiaki

AU - Iguchi, Tomohiro

AU - Morita, Kazutoyo

AU - Yamamoto, Ken

AU - Miyano, Satoru

AU - Mori, Masaki

AU - Maehara, Yoshihiko

AU - Mimori, Koshi

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

AB - Background: Here, we explored the genetic interactions between diabetes and oncogenic single-nucleotide polymorphisms (SNPs) that determine colorectal cancer (CRC) morbidity. Methods: 8q24 rs6983267 polymorphism analysis and cDNA microarray were performed in 107 CRCs to identify the genes associated with diabetes and the oncogenic SNP. Then clinical significance of the gene was validated in 132 CRCs. Meta-analysis of microarray data and diabetic comorbidity was performed. Results: Of genes associated with a minor SNP allele at 8q24, diabetes, and MYC overexpression, apolipoprotein A-IV (ApoA-IV) was associated with oncogenesis and poor prognosis in CRC patients. Patients with high ApoA-IV expression showed significantly poorer prognosis by univariate and multivariate analysis. Meta-analysis revealed lipid metabolism was associated with ApoA-IV-related oncogenesis in diabetic patients. Conclusions: Changes in lipid metabolism associated with aberrant expression of ApoA-IV were risks for CRC oncogenesis.

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