9-Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells

Norihiro Sato, Kazuhiro Mizumoto, Masahiro Kusumoto, Hideaki Niiyama, Naoki Maehara, Takahiro Ogawa, Masao Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

28 被引用数 (Scopus)


There is increasing interest in identifying potent inhibitors of telomerase because the enzyme plays a crucial role in the development of cellular immortality and carcinogenesis. We hypothesized that 9-hydroxyellipticine (9-HE), an antitumor alkaloid, would inhibit telomerase activity because the drug has a unique mechanism of inhibiting phosphorylation of mutant p53 protein via inhibition of protein kinases, thereby restoring wild-type p53 function. This study was conducted to examine the effect of 9-HE on telomerase activity in human pancreatic cancer cells with differing p53 gene status. 9-HE treatment at relatively high concentrations resulted in rapid, complete inhibition of telomerase activity, irrespective of the p53 status. We conclude that 9-HE may exert a strong inhibitory effect on telomerase activity possibly through inhibition of protein kinases rather than through restoration of functional wild-type p53. Copyright (C) 1998 Federation of European Biochemical Societies.

ジャーナルFEBS Letters
出版ステータス出版済み - 12月 18 1998

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学


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