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2016
33 引用 (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., 8 31 2016, : : Scientific reports. 6, 32461.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
24 引用 (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Wu, Z., Kohsaka, S., Inoue, K. & Nakanishi, H., 5 31 2016, : : Nature communications. 7, 11697.

研究成果: ジャーナルへの寄稿記事

morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
19 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
49 引用 (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., 8 12 2016, : : Nature communications. 7, 12529.

研究成果: ジャーナルへの寄稿記事

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
19 引用 (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 10 2016, : : PloS one. 11, 10, e0165189.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
31 引用 (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., 10 14 2016, : : Nature communications. 7, 13102.

研究成果: ジャーナルへの寄稿記事

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Tsuda, M., Inoue, K., Ojida, A., Koyanagi, S. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
41 引用 (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., 5 1 2016, : : Neuropharmacology. 104, p. 76-81 6 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors
31 引用 (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., 1 19 2016, : : Science Signaling. 9, 411, aac9187.

研究成果: ジャーナルへの寄稿記事

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Tsuda, M. & Inoue, K., 1 1 2016, : : Seikagaku. 88, 1, p. 124-127 4 p.

研究成果: ジャーナルへの寄稿記事

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia

The frontline of drug creation for neuropathic pain

Inoue, K., 1 1 2016, : : Japanese Journal of Anesthesiology. 65, p. S136-S142

研究成果: ジャーナルへの寄稿記事

Neuralgia
Pharmaceutical Preparations
3 引用 (Scopus)

Transcriptional regulation in microglia and neuropathic pain

Masuda, T., Tsuda, M. & Inoue, K., 4 1 2016, : : Pain management. 6, 2, p. 91-94 4 p.

研究成果: ジャーナルへの寄稿編集

公開
Interferon Regulatory Factors
Purinergic P2 Receptors
Gene Expression Regulation
Microglia
Neuralgia
2017
31 引用 (Scopus)

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S. および1人, Kurose, H., 1 3 2017, : : Journal of Clinical Investigation. 127, 1, p. 383-401 19 p.

研究成果: ジャーナルへの寄稿記事

Myofibroblasts
Myocardial Infarction
Epidermal Growth Factor
Serum Response Factor
Extracellular Matrix Proteins
3 引用 (Scopus)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., 12 1 2017, : : Scientific reports. 7, 1, 4739.

研究成果: ジャーナルへの寄稿記事

Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
8 引用 (Scopus)

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T. A., Hosoi, M., Tsuda, M., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., 12 1 2017, : : Scientific reports. 7, 1, 11882.

研究成果: ジャーナルへの寄稿記事

Translational Medical Research
Fibromyalgia
Microglia
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
7 引用 (Scopus)

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Inoue, K., 1 1 2017, : : Yakugaku Zasshi. 137, 5, p. 563-569 7 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuroglia
Pain
Purinergic P2X4 Receptors
Neuralgia
4 引用 (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
12 引用 (Scopus)
pathogenesis
Purinergic P2X4 Receptors
pain
neuroglia
Microglia
2018
2 引用 (Scopus)

A state-of-the-art perspective on microgliopathic pain

Inoue, K., 11 1 2018, : : Open Biology. 8, 11, 180154.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Pain
Peripheral Nerve Injuries
Chronic Pain
3 引用 (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 5 1 2018, : : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

研究成果: ジャーナルへの寄稿記事

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., 1 1 2018, : : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
56 引用 (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Tsuda, M., 2 16 2018, : : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
8 引用 (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., 1 1 2018, : : eNeuro. 5, 1, e0450-17.2018.

研究成果: ジャーナルへの寄稿記事

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
6 引用 (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 1 1 2018, : : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
22 引用 (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., 12 1 2018, : : Nature communications. 9, 1, 1886.

研究成果: ジャーナルへの寄稿記事

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., 1 25 2019, : : Purinergic Signalling.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head
2 引用 (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., 3 15 2019, : : Purinergic Signalling. 15, 1, p. 27-35 9 p.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., 3 30 2019, : : Journal of neuroinflammation. 16, 1, 67.

研究成果: ジャーナルへの寄稿記事

公開
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord
1 引用 (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori-Hayashi, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Kido-Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Tsuda, M., 3 2019, : : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

研究成果: ジャーナルへの寄稿記事

Purinergic P2X3 Receptors
2 引用 (Scopus)

Role of the P2X4 receptor in neuropathic pain

Inoue, K., 8 2019, : : Current Opinion in Pharmacology. 47, p. 33-39 7 p.

研究成果: ジャーナルへの寄稿評論記事

Purinergic P2X4 Receptors
Neuralgia
Purinergic P2 Receptors
Pain
Peripheral Nerve Injuries
4 引用 (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., 4 2019, : : GLIA. 67, 4, p. 729-740 12 p.

研究成果: ジャーナルへの寄稿記事

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity