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2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., 12 1 2017, : : Scientific Reports. 7, 1, 6528.

研究成果: ジャーナルへの寄稿記事

公開
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
26 引用 (Scopus)
Mitochondrial DNA
Neurons
Antioxidants
Neurodegenerative Diseases
Cytosine
67 引用 (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., 12 3 2012, : : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

研究成果: ジャーナルへの寄稿記事

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
67 引用 (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., 4 1 2014, : : Scientific reports. 4, 4689.

研究成果: ジャーナルへの寄稿記事

Germ-Line Mutation
Mutation
Germ Cells
Exome
DNA
10 引用 (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., 7 2017, : : PloS one. 12, 7, e0181687.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
60 引用 (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., 12 17 2012, : : PloS one. 7, 12, e51697.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
glycosylases
obesity
Obesity
Fats
13 引用 (Scopus)

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice

Isoda, T., Nakatsu, Y., Yamauchi, K., Piao, J., Yao, T., Honda, H., Nakabeppu, Y. & Tsuzuki, T., 8 23 2014, : : International journal of biological sciences. 10, 8, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

abnormality
tumor
carcinogenesis
Carcinogenesis
Oxidative Stress
7 引用 (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., 1 1 2014, : : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

Prion Diseases
Prions
DNA Damage
Repair
DNA Repair
118 引用 (Scopus)

Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., Kiyohara, Y. & Nakabeppu, Y., 9 2014, : : Cerebral Cortex. 24, 9, p. 2476-2488 13 p.

研究成果: ジャーナルへの寄稿記事

Alzheimer Disease
Brain
Genes
Diabetes Mellitus
Brain Diseases
2 引用 (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., 12 1 2018, : : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

研究成果: ジャーナルへの寄稿記事

Polymorphism
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Nucleotides
Genes
3 引用 (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., 8 2018, : : Annals of Neurology. 84, 2, p. 208-224 17 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
15 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 2 15 2011, : : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

研究成果: ジャーナルへの寄稿記事

DNA-(Apurinic or Apyrimidinic Site) Lyase
B-Lymphoid Precursor Cells
Endonucleases
B-Lymphocytes
DNA Repair
5 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., 7 15 2014, : : Journal of Immunology. 193, 2, p. 931-939 9 p.

研究成果: ジャーナルへの寄稿記事

DNA-(Apurinic or Apyrimidinic Site) Lyase
Germinal Center
DNA Damage
B-Lymphocytes
DNA Repair
6 引用 (Scopus)

A role for SNX1 in the regulation of EGF-dependent phosphorylated EGFR endocytosis via the early/late endocytic pathway in a gefitinib-sensitive human lung cancer cells

Nishimura, Y., Yoshioka, K., Takiguchi, S., Bereczky, B., Nakabeppu, Y. & Itoh, K., 9 1 2011, : : Current Signal Transduction Therapy. 6, 3, p. 383-395 13 p.

研究成果: ジャーナルへの寄稿記事

Endosomes
Endocytosis
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Lung Neoplasms
10 引用 (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., 1 2018, : : Brain Pathology. 28, 1, p. 58-71 14 p.

研究成果: ジャーナルへの寄稿記事

Adipocytes
Hippocampus
Carrier Proteins
Pathology
Alzheimer Disease
5 引用 (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., 7 1 2017, : : Lung Cancer. 109, p. 52-57 6 p.

研究成果: ジャーナルへの寄稿記事

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Neoplasms
Antioxidants
Nucleoside-Triphosphatase
12 引用 (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., 6 1 2011, : : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

研究成果: ジャーナルへの寄稿記事

Nerve Tissue
Guanosine Triphosphate
Nucleotides
Spinal Ganglia
Neoplasms
14 引用 (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., 1 1 2017, : : Cancer Science. 108, 1, p. 108-115 8 p.

研究成果: ジャーナルへの寄稿記事

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
81 引用 (Scopus)
nucleotides
DNA Glycosylases
Nucleotides
Cell Survival
Carcinogenesis
6 引用 (Scopus)

Characterization of galectin-1-positive cells in the mouse hippocampus

Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H. & Nakabeppu, Y., 2 12 2014, : : NeuroReport. 25, 3, p. 171-176 6 p.

研究成果: ジャーナルへの寄稿記事

Galectin 1
Hippocampus
Tubulin
Interneurons
Galectins
12 引用 (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., 12 1 2017, : : Brain Research. 1676, p. 77-82 6 p.

研究成果: ジャーナルへの寄稿記事

Neurogenesis
Haloperidol
Bromodeoxyuridine
olanzapine
Antipsychotic Agents
19 引用 (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., 12 1 2017, : : Scientific reports. 7, 1, 17762.

研究成果: ジャーナルへの寄稿記事

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
5 引用 (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., 9 1 2017, : : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

研究成果: ジャーナルへの寄稿記事

Ghrelin
Parkinson Disease
Hydrogen
Water
Knockout Mice
4 引用 (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 2 1 2017, : : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

研究成果: ジャーナルへの寄稿レター

Neoplastic Gene Expression Regulation
Chemokine CXCL1
Radiation-Induced Neoplasms
Versicans
DNA Glycosylases
4 引用 (Scopus)
3 引用 (Scopus)

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

Koga, Y., Inazato, M., Nakamura, T., Hashikawa, C., Chirifu, M., Michi, A., Yamashita, T., Toma, S., Kuniyasu, A., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., 1 1 2013, : : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 45-48 4 p.

研究成果: ジャーナルへの寄稿記事

X ray analysis
Crystallization
nucleosides
X-Rays
crystallization
22 引用 (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. および8人, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., 11 1 2016, : : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

研究成果: ジャーナルへの寄稿記事

Deoxyribonuclease (Pyrimidine Dimer)
Autoimmunity
DNA Repair
B-Lymphocytes
Enzymes
4 引用 (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., 9 13 2016, : : Scientific reports. 6, 32849.

研究成果: ジャーナルへの寄稿記事

DNA
Growth
Deamination
deoxyinosine
triphosphoric acid

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (版) & Ninomiya, T. (版), 5 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

研究成果: 著書/レポートタイプ著書

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
18 引用 (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., 6 1 2014, : : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

研究成果: ジャーナルへの寄稿記事

T Cell Transcription Factor 1
Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
Tumors
27 引用 (Scopus)

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Stavnezer, J., Linehan, E. K., Thompson, M. R., Habboub, G., Ucher, A. J., Kadungure, T., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 6 24 2014, : : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9217-9222 6 p.

研究成果: ジャーナルへの寄稿記事

Germinal Center
B-Lymphocytes
Uracil-DNA Glycosidase
Base Pairing
DNA-(Apurinic or Apyrimidinic Site) Lyase
10 引用 (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., 1 1 2015, : : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

研究成果: ジャーナルへの寄稿記事

Growth
Neoplasms
Intestinal Neoplasms
Catenins
Dictyostelium
42 引用 (Scopus)
DNA Glycosylases
Carcinogenesis
Oxidative Stress
Cell Death
DNA
7 引用 (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., 6 2014, : : Neuropathology. 34, 3, p. 284-290 7 p.

研究成果: ジャーナルへの寄稿記事

Hepatocyte Growth Factor
Hippocampus
Alzheimer Disease
Down-Regulation
Pyramidal Cells
1 引用 (Scopus)

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 6 1 2013, : : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

Neurogenesis
Epilepsy
Genome
DNA
Research
Genes
1 引用 (Scopus)

Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., 3 23 2015, : : Nucleic acids research. 43, 7, p. 3870-3871 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

Forensic Anthropology
Nucleic Acids
Mitochondria
DNA
Enzymes
3 引用 (Scopus)
DNA Glycosylases
Carcinogenesis
Cell Death
Neoplasms
4-iodo-2,5-dimethoxyphenylisopropylamine
1 引用 (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 6 10 2016, : : Scientific reports. 6, 27164.

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., 6 2018, : : Neuropathology. 38, 3, p. 247-259 13 p.

研究成果: ジャーナルへの寄稿記事

Pyramidal Tracts
Amyotrophic Lateral Sclerosis
Pyramidal Cells
Kidney
Cerebral Cortex
4 引用 (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., 11 2017, : : Pathology International. 67, 11, p. 564-574 11 p.

研究成果: ジャーナルへの寄稿記事

Chromosome Aberrations
Carcinogenesis
Kidney
Genotype
Methylation
21 引用 (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., 8 2014, : : GLIA. 62, 8, p. 1284-1298 15 p.

研究成果: ジャーナルへの寄稿記事

Anaphylatoxin C5a Receptor
Complement C5a
Complement Receptors
Microglia
Kainic Acid
22 引用 (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., 9 1 2011, : : Biological Psychiatry. 70, 5, p. 487-495 9 p.

研究成果: ジャーナルへの寄稿記事

Cadherins
Genes
Alleles
Locomotion
Mood Disorders
22 引用 (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 4 1 2013, : : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

研究成果: ジャーナルへの寄稿記事

Neurogenesis
Epilepsy
Hippocampus
Lateral Ventricles
Depression

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., 6 5 2016, : : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

研究成果: ジャーナルへの寄稿評論記事

公開
6 引用 (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., 2 1 2015, : : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

研究成果: ジャーナルへの寄稿記事

Galectin 1
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Axons
23 引用 (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Kunihiko, S., Nakabeppu, Y., Poirier, F. & Sango, K., 2 1 2013, : : Neurochemistry International. 62, 3, p. 330-339 10 p.

研究成果: ジャーナルへの寄稿記事

Galectin 1
Glial Cell Line-Derived Neurotrophic Factor
Phosphatidylinositol Phosphates
Spinal Ganglia
Phosphotransferases
16 引用 (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., 11 29 2016, : : Scientific reports. 6, 37889.

研究成果: ジャーナルへの寄稿記事

Alzheimer Disease
Mitochondria
Prealbumin
Mitochondrial DNA
Oxidative Stress
10 引用 (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 3 10 2016, : : Scientific reports. 6, 22991.

研究成果: ジャーナルへの寄稿記事

Pro-Opiomelanocortin
Premature Mortality
Malformations of Cortical Development
Epilepsy
Neurons