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著者

  • Yusaku Nakabeppu

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 12 1 2011, : : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y. & Nishigori, C., 1 1 2014, : : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

International symposium on “germline mutagenesis and Biodiversification”

Uchimura, A., Hara, Y., Gondo, Y. & Nakabeppu, Y., 9 1 2014, : : Genes and Genetic Systems. 89, 2, p. 93-95 3 p.

研究成果: ジャーナルへの寄稿編集

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes

Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K. & Kitazono, T., 1 1 2014, : : Arteriosclerosis, thrombosis, and vascular biology. 34, 1, p. 44-51 8 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., 1 15 2017, : : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E. & Abolhassani, N., 6 1 2017, : : Free Radical Biology and Medicine. 107, p. 151-158 8 p.

研究成果: ジャーナルへの寄稿評論記事

20 引用 (Scopus)

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

Murakami, Y., Ikeda, Y., Yoshida, N., Notomi, S., Hisatomi, T., Oka, S., De Luca, G., Yonemitsu, Y., Bignami, M., Nakabeppu, Y. & Ishibashi, T., 10 1 2012, : : American Journal of Pathology. 181, 4, p. 1378-1386 9 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Oka, S., Leon, J., Tsuchimoto, D., Sakumi, K. & Nakabeppu, Y., 1 1 2014, : : Oncogenesis. 3, 10, e121.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 1 1 2016, : : JCI Insight. 1, 15, e87781.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 9 22 2016, : : JCI insight. 1, 15, 15 p., e87781.

研究成果: ジャーナルへの寄稿記事

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Tsuji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M. & Sado, T., 5 1 2013, : : Journal of radiation research. 54, 3, p. 453-466 14 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.

Nakabeppu, Y., 4 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.

研究成果: 著書/レポートタイプへの貢献

Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus

Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M. S., Lee, K. U., Shaw, C. A., Lim, J., Nakabeppu, Y. & Hara, T., 9 1 2013, : : European Journal of Medical Genetics. 56, 9, p. 475-483 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., 10 1 2016, : : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Nucleotides function as endogenous chemical sensors for oxidative stress signaling

Ihara, H., Sawa, T., Nakabeppu, Y. & Akaike, T., 1 1 2011, : : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 33-39 7 p.

研究成果: ジャーナルへの寄稿評論記事

9 引用 (Scopus)

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., 1 1 2020, : : PloS one. 15, 1, e0227501.

研究成果: ジャーナルへの寄稿記事

公開

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M. & Nakaya, H., 11 29 2013, : : Scientific reports. 3, 3273.

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Tsuzuki, T., Piao, J. S., Isoda, T., Sakumi, K., Nakabeppu, Y. & Nakatsu, Y., 3 1 2011, : : Health physics. 100, 3, p. 293-294 2 p.

研究成果: ジャーナルへの寄稿Conference article

1 引用 (Scopus)

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., 10 1 2016, : : Genes to Cells. 21, 10, p. 1030-1048 19 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., 1 1 2017, : : Cancer Medicine. 6, 1, p. 258-266 9 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes

Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., 10 2017, : : DNA Repair. 58, p. 13-20 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation

Kajitani, K., Yanagimoto, K. & Nakabeppu, Y., 10 1 2017, : : Psychopharmacology. 234, 19, p. 2919-2927 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines

Nishimura, Y., Takiguchi, S., Yoshioka, K., Nakabeppu, Y. & Itoh, K., 10 1 2012, : : International journal of oncology. 41, 4, p. 1520-1530 11 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

Yogianti, F., Kunisada, M., Ono, R., Sakumi, K., Nakabeppu, Y. & Nishigori, C., 11 1 2012, : : Mutagenesis. 27, 6, p. 637-643 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., 2 17 2017, : : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Bjørge, M. D., Hildrestrand, G. A., Scheffler, K., Suganthan, R., Rolseth, V., Kuśnierczyk, A., Rowe, A. D., Vågbø, C. B., Vetlesen, S., Eide, L., Slupphaug, G., Nakabeppu, Y., Bredy, T. W., Klungland, A. & Bjørås, M., 12 29 2015, : : Cell Reports. 13, 12, p. 2671-2678 8 p.

研究成果: ジャーナルへの寄稿記事

公開
17 引用 (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., 5 1 2018, : : Neuroscience. 377, p. 87-97 11 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)
29 引用 (Scopus)

Therapeutic effects of hydrogen in animal models of Parkinson's disease

Fujita, K., Nakabeppu, Y. & Noda, M., 9 19 2011, : : Parkinson's Disease. 307875.

研究成果: ジャーナルへの寄稿評論記事

10 引用 (Scopus)

What have we learned from cultured adult dorsal root ganglion neurons?

Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T. & Horie, H., 1 1 2014, Ganglion Cells: Morphology, Functional Development and Role in Disease. Nova Science Publishers, Inc., p. 125-148 24 p.

研究成果: 著書/レポートタイプへの貢献