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著者

  • Yusaku Nakabeppu

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., 12 1 2017, : : Scientific Reports. 7, 1, 6528.

研究成果: ジャーナルへの寄稿記事

公開
28 引用 (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., 12 3 2012, : : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

研究成果: ジャーナルへの寄稿記事

68 引用 (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., 4 1 2014, : : Scientific reports. 4, 4689.

研究成果: ジャーナルへの寄稿記事

72 引用 (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., 7 2017, : : PloS one. 12, 7, e0181687.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., 12 17 2012, : : PloS one. 7, 12, e51697.

研究成果: ジャーナルへの寄稿記事

62 引用 (Scopus)

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice

Isoda, T., Nakatsu, Y., Yamauchi, K., Piao, J., Yao, T., Honda, H., Nakabeppu, Y. & Tsuzuki, T., 8 23 2014, : : International journal of biological sciences. 10, 8, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., 3 2014, : : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., Kiyohara, Y. & Nakabeppu, Y., 9 2014, : : Cerebral Cortex. 24, 9, p. 2476-2488 13 p.

研究成果: ジャーナルへの寄稿記事

123 引用 (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., 12 1 2018, : : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., 8 2018, : : Annals of Neurology. 84, 2, p. 208-224 17 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge

Guikema, J. E. J., Gerstein, R. M., Linehan, E. K., Cloherty, E. K., Evan-Browning, E., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 2 15 2011, : : Journal of Immunology. 186, 4, p. 1943-1950 8 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells

Guikema, J. E. J., Linehan, E. K., Esa, N., Tsuchimoto, D., Nakabeppu, Y., Woodland, R. T. & Schrader, C. E., 7 15 2014, : : Journal of Immunology. 193, 2, p. 931-939 9 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

A role for SNX1 in the regulation of EGF-dependent phosphorylated EGFR endocytosis via the early/late endocytic pathway in a gefitinib-sensitive human lung cancer cells

Nishimura, Y., Yoshioka, K., Takiguchi, S., Bereczky, B., Nakabeppu, Y. & Itoh, K., 9 1 2011, : : Current Signal Transduction Therapy. 6, 3, p. 383-395 13 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., 1 2018, : : Brain Pathology. 28, 1, p. 58-71 14 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., 7 1 2017, : : Lung Cancer. 109, p. 52-57 6 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Cancer-related PRUNE2 protein is associated with nucleotides and is highly expressed in mature nerve tissues

Iwama, E., Tsuchimoto, D., Iyama, T., Kunihiko, S., Nakagawara, A., Takayama, K., Nakanishi, Y. & Nakabeppu, Y., 6 1 2011, : : Journal of Molecular Neuroscience. 44, 2, p. 103-114 12 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., 1 1 2017, : : Cancer Science. 108, 1, p. 108-115 8 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)
85 引用 (Scopus)

Characterization of galectin-1-positive cells in the mouse hippocampus

Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H. & Nakabeppu, Y., 2 12 2014, : : NeuroReport. 25, 3, p. 171-176 6 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., 12 1 2017, : : Brain Research. 1676, p. 77-82 6 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., 12 1 2017, : : Scientific reports. 7, 1, 17762.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., 9 1 2017, : : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 2 1 2017, : : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

研究成果: ジャーナルへの寄稿レター

4 引用 (Scopus)
5 引用 (Scopus)

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

Koga, Y., Inazato, M., Nakamura, T., Hashikawa, C., Chirifu, M., Michi, A., Yamashita, T., Toma, S., Kuniyasu, A., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., 1 1 2013, : : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 45-48 4 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. および8人, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., 11 1 2016, : : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., 9 13 2016, : : Scientific reports. 6, 32849.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Igawa, K., Tomooka, K., Watanabe, Y., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y. & Sasaguri, T., 6 1 2014, : : Biochemical Pharmacology. 89, 3, p. 340-348 9 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

Stavnezer, J., Linehan, E. K., Thompson, M. R., Habboub, G., Ucher, A. J., Kadungure, T., Tsuchimoto, D., Nakabeppu, Y. & Schrader, C. E., 6 24 2014, : : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9217-9222 6 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., 1 1 2015, : : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)
44 引用 (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., 6 2014, : : Neuropathology. 34, 3, p. 284-290 7 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)
3 引用 (Scopus)

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 6 1 2013, : : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 6 10 2016, : : Scientific reports. 6, 27164.

研究成果: ジャーナルへの寄稿コメント/討論

Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., 3 23 2015, : : Nucleic acids research. 43, 7, p. 3870-3871 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

2 引用 (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., 6 2018, : : Neuropathology. 38, 3, p. 247-259 13 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., 11 2017, : : Pathology International. 67, 11, p. 564-574 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., 8 2014, : : GLIA. 62, 8, p. 1284-1298 15 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., 9 1 2011, : : Biological Psychiatry. 70, 5, p. 487-495 9 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 4 1 2013, : : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., 6 5 2016, : : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

研究成果: ジャーナルへの寄稿評論記事

公開

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., 2 1 2015, : : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Sakumi, K., Nakabeppu, Y., Poirier, F. & Sango, K., 2 1 2013, : : Neurochemistry International. 62, 3, p. 330-339 10 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., 11 29 2016, : : Scientific reports. 6, 37889.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 3 10 2016, : : Scientific reports. 6, 22991.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 12 1 2011, : : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y. & Nishigori, C., 1 1 2014, : : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)