研究成果の検索

すべてのコンテンツを検索

研究成果 のフィルター

検索コンセプト
選択されたフィルター

出版年

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2014
  • 2013
  • 2011

著者

  • Koichi Akashi

Efficacy and safety of tisagenlecleucel in Japanese adult patients with relapsed/refractory diffuse large B-cell lymphoma

Goto, H., Makita, S., Kato, K., Tokushige, K., Fujita, T., Akashi, K., Izutsu, K. & Teshima, T., 9 1 2020, : : International Journal of Clinical Oncology. 25, 9, p. 1736-1743 8 p.

研究成果: Contribution to journalArticle

公開

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., 9 13 2016, : : Stem Cell Reports. 7, 3, p. 425-438 14 p.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

Eosinophilopoiesis

Maltby, S., McNagny, K. M., Ackerman, S. J., Du, J., Mori, Y., Iwasaki, H., Akashi, K., Takatsu, K., Rådinger, M., Bossios, A., Lötvall, J. & Lee, N. A., 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 73-119 47 p.

研究成果: Chapter in Book/Report/Conference proceedingChapter

1 引用 (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 12 2018, : : Cancer Science. 109, 12, p. 3874-3882 9 p.

研究成果: Contribution to journalArticle

3 引用 (Scopus)

Epithelial-mesenchymal transition is activated in CD44-positive malignant ascites tumor cells of gastrointestinal cancer

Nakano, M., Ito, M., Tanaka, R., Ariyama, H., Mitsugi, K., Makiyama, A., Uchino, K., Esaki, T., Tsuruta, N., Hanamura, F., Yamaguchi, K., Okumura, Y., Sagara, K., Takayoshi, K., Nio, K., Tsuchihashi, K., Tamura, S., Shimokawa, H., Arita, S., Miyawaki, K. および3人, Kusaba, H., Akashi, K. & Baba, E., 11 2018, : : Cancer Science. 109, 11, p. 3461-3470 10 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)

Erratum: Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack (Blood Adv) (2018) 2:4 (390-400) DOI: 10.1182/bloodadvances.201701334)

Espinoza, J. L., Elbadry, M. I., Chonabayashi, K., Yoshida, Y., Katagiri, T., Harada, K., Nakagawa, N., Zaimoku, Y., Imi, T., Takamatsu, H., Ozawa, T., Maruyama, H., Hassanein, H. A., Noreldin, A. K. A., Takenaka, K., Akashi, K., Hamana, H., Kishi, H., Akatsuka, Y. & Nakao, S., 9 11 2018, : : Blood Advances. 2, 17, p. 2253 1 p.

研究成果: Contribution to journalComment/debate

Erratum to: Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis (International Journal of Hematology, (2017), 105, 3, (309-317), 10.1007/s12185-016-2130-z)

Komatsu, N., Kirito, K., Shimoda, K., Ishikawa, T., Ohishi, K., Ohyashiki, K., Takahashi, N., Okada, H., Amagasaki, T., Yonezu, T. & Akashi, K., 3 1 2017, : : International journal of hematology. 105, 3, p. 387 1 p.

研究成果: Contribution to journalComment/debate

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

Elbadry, M. I., Mizumaki, H., Hosokawa, K., Espinoza, J. L., Nakagawa, N., Yoshida, Y., Katagiri, T., Hosomichi, K., Zaimoku, Y., Imi, T., Nguyen, M. A. T., Fujii, Y., Tajima, A., Ogawa, S., Takenaka, K., Akashi, K. & Nakao, S., 2019, : : Haematologica. 104, 10, p. E447-E450

研究成果: Contribution to journalLetter

公開

Evaluating the association between histological manifestations of cord colitis syndrome with GVHD

Shimoji, S., Kato, K., Eriguchi, Y., Takenaka, K., Iwasaki, H., Miyamoto, T., Oda, Y., Akashi, K. & Teshima, T., 9 2013, : : Bone Marrow Transplantation. 48, 9, p. 1249-1252 4 p.

研究成果: Contribution to journalArticle

15 引用 (Scopus)

Evaluation of clinical performance of the major BCR-ABL mRNA detection kit which enables conversion to international standard scale using the reference material calibrator.

Miyamura, K., Okamoto, S., Usui, N., Hino, M., Akashi, K., Nakaseko, T., Takahashi, N., Nakatani, K., Takahashi, K., Nobori, T. & Naoe, T., 5 2014, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 5, p. 534-540 7 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)

Evaluation of the compliance with antiemetic guidelines for prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancy

Uchida, M., Nakamura, T., Shima, T., Mori, Y., Yoshimoto, G., Kato, K., Shimokawa, M., Hosohata, K., Miyamoto, T. & Akashi, K., 2019, : : Pharmazie. 74, 4, p. 250-254 5 p.

研究成果: Contribution to journalArticle

Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis

Kirito, K., Okamoto, S., Ohishi, K., Tauchi, T., Handa, H., Saito, S., Takenaka, K., Shimoda, K., Oritani, K., Akashi, K., Okada, H., Amagasaki, T., Suzuki, K., Yonezu, T. & Komatsu, N., 1 1 2018, : : International journal of hematology. 107, 1, p. 92-97 6 p.

研究成果: Contribution to journalArticle

2 引用 (Scopus)
18 引用 (Scopus)

Evaluation of the feasibility and efficacy of autologous stem cell transplantation in elderly patients with multiple myeloma

Muta, T., Miyamoto, T., Fujisaki, T., Ohno, Y., Kamimura, T., Kato, K., Takenaka, K., Iwasaki, H., Eto, T., Takamatsu, Y., Teshima, T. & Akashi, K., 2013, : : Internal Medicine. 52, 1, p. 63-70 8 p.

研究成果: Contribution to journalArticle

34 引用 (Scopus)

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Koyama, M., Hashimoto, D., Nagafuji, K., Eto, T., Ohno, Y., Aoyama, K., Iwasaki, H., Miyamoto, T., Hill, G. R., Akashi, K. & Teshima, T., 2014, : : Bone Marrow Transplantation. 49, 1, p. 110-115 6 p.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Expansion of NKG2C-expressing natural killer cells after umbilical cord blood transplantation in a patient with peripheral T-cell lymphoma with cytotoxic molecules

Muta, T., Yoshihiro, T., Jinnouchi, F., Aoki, K., Kochi, Y., Shima, T., Takenaka, K., Ogawa, R., Akashi, K. & Oshima, K., 2018, : : Internal Medicine. 57, 6, p. 861-866 6 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)

Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes

Tsuzuki, H., Arinobu, Y., Miyawaki, K., Takaki, A., Ota, S. I., Ota, Y., Mitoma, H., Akahoshi, M., Mori, Y., Iwasaki, H., Niiro, H., Tsukamoto, H. & Akashi, K., 1 1 2017, : : Immunology. 150, 1, p. 64-73 10 p.

研究成果: Contribution to journalArticle

9 引用 (Scopus)

Further assessment of atrial fibrillation as a risk factor for gastroesophageal reflux disease: A multicenter questionnaire survey

Kubota, S., Nakaji, G., Shimazu, H., Odashiro, K., Maruyama, T. & Akashi, K., 11 11 2013, : : Internal Medicine. 52, 21, p. 2401-2407 7 p.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Gastrointestinal Graft-versus-Host Disease Is a Risk Factor for Postengraftment Bloodstream Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Mori, Y., Yoshimoto, G., Nishida, R., Sugio, T., Miyawaki, K., Shima, T., Nagasaki, Y., Miyake, N., Harada, Y., Kunisaki, Y., Kamezaki, K., Numata, A., Kato, K., Shiratsuchi, M., Maeda, T., Takenaka, K., Iwasaki, H., Shimono, N., Akashi, K. & Miyamoto, T., 11 2018, : : Biology of Blood and Marrow Transplantation. 24, 11, p. 2302-2309 8 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)

Generation mechanism of RANKL+ effector memory B cells: Relevance to the pathogenesis of rheumatoid arthritis

Ota, Y., Niiro, H., Ota, S. I., Ueki, N., Tsuzuki, H., Nakayama, T., Mishima, K., Higashioka, K., Jabbarzadeh-Tabrizi, S., Mitoma, H., Akahoshi, M., Arinobu, Y., Kukita, A., Yamada, H., Tsukamoto, H. & Akashi, K., 3 16 2016, : : Arthritis Research and Therapy. 18, 1, 67.

研究成果: Contribution to journalArticle

14 引用 (Scopus)
1 引用 (Scopus)

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., Nakamura, J., Hasegawa, Y., Akashi, K., Narita, I., Miyamoto, T., Takeuchi, T., Ikari, K., Amano, K., Fujie, A., Kubo, T., Tada, Y., Kaneuji, A., Nakamura, H., Miyamura, T. および70人, Kabata, T., Yamaji, K., Okawa, T., Sudo, A., Ohzono, K., Tanaka, Y., Yasunaga, Y., Matsuda, S., Imai, Y., Nakashima, Y., Motomura, G., Ikemura, S., Yamaguchi, R., Karasuyama, K., Sonoda, K., Nishii, T., Sakai, T., Takao, M., Irie, T., Asano, T., Iwasaki, N., Atsumi, T., Tamaoki, S., Nakanishi, R., Tanabe, S., Kishida, S., Hagiwara, S., Seki, T., Tsukamoto, H., Niiro, H., Arinobu, Y., Akahoshi, M., Mitoma, H., Ayano, M., Kuroda, T., Toyama, Y., Funayama, A., Hanaoka, H., Yamaoka, K., Kawaguchi, Y., Yamanaka, H., Hosozawa, T., Momohara, S., Chino, K., Fujioka, M., Ueshima, K., Ishida, M., Saito, M., Hayashi, S., Ikegami, A., Ichiseki, T., Mizokawa, S., Ohta, Y., Kajino, Y., Sekiya, F., Higuchi, F., Hasegawa, M., Miyamoto, N., Miyazaki, S., Yamaguchi, T., Ando, W., Saito, K., Nakano, K., Kuroda, Y., Yamasaki, T., Akiyama, M., Kubo, M., Kamatani, Y., Iwamoto, Y. & Ikegawa, S., 12 1 2017, : : Scientific reports. 7, 1, 15035.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

Yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. および2人, Bauer, D. E. & Maeda, T., 3 12 2018, : : Cancer Cell. 33, 3, p. 386-400.e5

研究成果: Contribution to journalArticle

25 引用 (Scopus)

Glucose signaling in the brain and periphery to memory

Hossain, M. S., Oomura, Y., Fujino, T. & Akashi, K., 3 2020, : : Neuroscience and Biobehavioral Reviews. 110, p. 100-113 14 p.

研究成果: Contribution to journalReview article

Graft-versus-host disease targets ovary and causes female infertility in mice

Shimoji, S., Hashimoto, D., Tsujigiwa, H., Miyawaki, K., Kato, K., Takahashi, S., Ogasawara, R., Jiromaru, T., Iwasaki, H., Miyamoto, T., Akashi, K. & Teshima, T., 3 2 2017, : : Blood. 129, 9, p. 1216-1225 10 p.

研究成果: Contribution to journalArticle

9 引用 (Scopus)

Guest editorial: Leukemia stem cell

Akashi, K., 12 1 2013, : : International journal of hematology. 98, 6, p. 625-626 2 p.

研究成果: Contribution to journalEditorial

1 引用 (Scopus)

Helicobacter cinaedi bacteremia mimicking a flare of systemic lupus erythematosus

Nishida, R., Shimono, N., Miyake, N., Chong, Y., Shimoda, S., Tsukamoto, H. & Akashi, K., 2017, : : Internal Medicine. 56, 6, p. 725-728 4 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)

Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer

Yamaguchi, K., Ito, M., Ohmura, H., Hanamura, F., Nakano, M., Tsuchihashi, K., Nagai, S., Ariyama, H., Kusaba, H., Yamamoto, H., Oda, Y., Nakamura, M., Akashi, K. & Baba, E., 1 1 2020, : : OncoImmunology. 9, 1, 1724763.

研究成果: Contribution to journalArticle

公開
1 引用 (Scopus)

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack

Espinoza, J. L., Elbadry, M. I., Chonabayashi, K., Yoshida, Y., Katagiri, T., Harada, K., Nakagawa, N., Zaimoku, Y., Imi, T., Takamatsu, H., Ozawa, T., Maruyama, H., Hassanein, H. A., Noreldin, A. K. A., Takenaka, K., Akashi, K., Hamana, H., Kishi, H., Akatsuka, Y. & Nakao, S., 2 27 2018, : : Blood Advances. 2, 4, p. 390-400 11 p.

研究成果: Contribution to journalArticle

公開
10 引用 (Scopus)

Hepatitis C virus infection is an independent prognostic factor in follicular lymphoma

Shimono, J., Miyoshi, H., Kato, T., Sugio, T., Miyawaki, K., Kamimura, T., Miyagishima, T., Eto, T., Imaizumi, Y., Kato, K., Nagafuji, K., Akashi, K., Seto, M., Teshima, T. & Ohshima, K., 2018, : : Oncotarget. 9, 2, p. 1717-1725 9 p.

研究成果: Contribution to journalArticle

3 引用 (Scopus)

Higher incidence of injection site reactions after subcutaneous bortezomib administration on the thigh compared with the abdomen

Kamimura, T., Miyamoto, T., Yokota, N., Takashima, S., Chong, Y., Ito, Y. & Akashi, K., 2 2013, : : European Journal of Haematology. 90, 2, p. 157-161 5 p.

研究成果: Contribution to journalArticle

15 引用 (Scopus)

High incidence and severity of injection site reactions in the first cycle compared with subsequent cycles of subcutaneous bortezomib

Kamimura, T., Miyamoto, T., Yokota, N., Aoki, T., Ito, Y. & Akashi, K., 12 2013, : : International journal of hematology. 98, 6, p. 694-701 8 p.

研究成果: Contribution to journalArticle

3 引用 (Scopus)

Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells

Inokuchi, S., Mitoma, H., Kawano, S., Nakano, S., Ayano, M., Kimoto, Y., Akahoshi, M., Arinobu, Y., Tsukamoto, H., Akashi, K., Horiuchi, T. & Niiro, H., 4 15 2020, : : Journal of Immunology. 204, 8, p. 2088-2097 10 p.

研究成果: Contribution to journalArticle

HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors

Yoneshima, Y., Kato, K., Minami, H., Ikeda, M., Watanabe, H., Yoshimoto, G., Miyamoto, T., Akashi, K., Nakanishi, Y. & Okamoto, I., 9 1 2020, : : Cancer Science. 111, 9, p. 3395-3396 2 p.

研究成果: Contribution to journalLetter

公開
3 引用 (Scopus)

Human STEAP3 maintains tumor growth under hypoferric condition

Isobe, T., Baba, E., Arita, S., Komoda, M., Tamura, S., Shirakawa, T., Ariyama, H., Takaishi, S., Kusaba, H., Ueki, T. & Akashi, K., 11 1 2011, : : Experimental Cell Research. 317, 18, p. 2582-2591 10 p.

研究成果: Contribution to journalArticle

12 引用 (Scopus)

Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis

Hisamoto, S., Shimoda, S., Harada, K., Iwasaka, S., Onohara, S., Chong, Y., Nakamura, M., Bekki, Y., Yoshizumi, T., Ikegami, T., Maehara, Y., He, X. S., Gershwin, M. E. & Akashi, K., 12 1 2016, : : Journal of Autoimmunity. 75, p. 150-160 11 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients

Takayoshi, K., Kusaba, H., Aikawa, T., Koreishi, S., Sagara, K., Nakano, M., Komoda, M., Kono, M., Fukata, M., Arita, T., Esaki, T., Akashi, K. & Baba, E., 9 5 2019, : : Gastric Cancer. 22, 5, p. 988-998 11 p.

研究成果: Contribution to journalArticle

2 引用 (Scopus)

Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs

Kawamura, S., Onai, N., Miya, F., Sato, T., Tsunoda, T., Kurabayashi, K., Yotsumoto, S., Kuroda, S., Takenaka, K., Akashi, K. & Ohteki, T., 5 16 2017, : : Immunity. 46, 5, p. 835-848.e4

研究成果: Contribution to journalArticle

29 引用 (Scopus)

Identification of human erythroid lineage-committed progenitors

Mori, Y., Akashi, K. & Weissman, I. L., 5 1 2016, : : [Rinsho ketsueki] The Japanese journal of clinical hematology. 57, 5, p. 585-591 7 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Miyawaki, K., Iwasaki, H., Jiromaru, T., Kusumoto, H., Yurino, A., Sugio, T., Uehara, Y., Odawara, J., Daitoku, S., Kunisaki, Y., Mori, Y., Arinobu, Y., Tsuzuki, H., Kikushige, Y., Iino, T., Kato, K., Takenaka, K., Miyamoto, T., Maeda, T. & Akashi, K., 6 22 2017, : : Blood. 129, 25, p. 3332-3343 12 p.

研究成果: Contribution to journalArticle

23 引用 (Scopus)

Immunosuppressant therapy successfully improved regorafenib-induced severe hepatic injury in a patient with metastatic gastrointestinal stromal tumor: A case report

Kuwayama, M., Uchino, K., Takayoshi, K., Komoda, M., Kohjima, M., Nakamuta, M., Momosaki, S., Kusaba, H., Akashi, K. & Baba, E., 1 2016, : : Oncology Letters. 11, 1, p. 85-88 4 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)
公開
5 引用 (Scopus)

Impaired deformability of erythrocytes in diabetic rat and human: Investigation by the nickel-mesh-filtration technique

Saito, K., Kogawa, Y., Fukata, M., Odashiro, K., Maruyama, T., Akashi, K. & Fujino, T., 12 2011, : : Journal of Biorheology. 25, 1-2, p. 18-26 9 p.

研究成果: Contribution to journalArticle

6 引用 (Scopus)

Impaired erythrocyte deformability in patients with coronary risk factors: Significance of nonvalvular atrial fibrillation

Odashiro, K., Maruyama, T., Yokoyama, T., Nakamura, H., Fukata, M., Yasuda, S., Saito, K., Fujino, T. & Akashi, K., 10 2013, : : Journal of Atrial Fibrillation. 6, 3, p. 6-12 7 p.

研究成果: Contribution to journalArticle

Increasing diluent volume decreases bendamustine-induced venous irritation without reducing the therapeutic efficacy

Ishida, S., Morikawa, H., Watanabe, H., Tsuji, T., Sugio, T., Mori, Y., Miyamoto, T., Masuda, S., Akashi, K. & Egashira, N., 3 1 2020, : : Biological and Pharmaceutical Bulletin. 43, 3, p. 488-492 5 p.

研究成果: Contribution to journalArticle

公開

Infective endocarditis caused by Listeria monocytogenes forming a pseudotumor

Uehara Yonekawa, A., Iwasaka, S., Nakamura, H., Fukata, M., Kadowaki, M., Uchida, Y., Odashiro, K., Shimoda, S., Shimono, N. & Akashi, K., 2014, : : Internal Medicine. 53, 9, p. 1029-1032 4 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)

Influence of common cardiac drugs on gastroesophageal reflux disease: Multicenter questionnaire survey

Nakaji, G., Fujihara, M., Fukata, M., Yasuda, S., Odashiro, K., Maruyama, T. & Akashi, K., 9 2011, : : International Journal of Clinical Pharmacology and Therapeutics. 49, 9, p. 555-563 9 p.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Influence of medical history in parents or siblings on the development of systemic lupus erythematosus among Japanese females

Kyushu Sapporo SLE (KYSS) Study Group, 2016, : : International Medical Journal. 23, 5, p. 466-469 4 p.

研究成果: Contribution to journalArticle

Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

Karube, K., Enjuanes, A., Dlouhy, I., Jares, P., Martin-Garcia, D., Nadeu, F., Ordóñez, G. R., Rovira, J., Clot, G., Royo, C., Navarro, A., Gonzalez-Farre, B., Vaghefi, A., Castellano, G., Rubio-Perez, C., Tamborero, D., Briones, J., Salar, A., Sancho, J. M., Mercadal, S. および19人, Gonzalez-Barca, E., Escoda, L., Miyoshi, H., Ohshima, K., Miyawaki, K., Kato, K., Akashi, K., Mozos, A., Colomo, L., Alcoceba, M., Valera, A., Carrió, A., Costa, D., Lopez-Bigas, N., Schmitz, R., Staudt, L. M., Salaverria, I., López-Guillermo, A. & Campo, E., 3 1 2018, : : Leukemia. 32, 3, p. 675-684 10 p.

研究成果: Contribution to journalArticle

50 引用 (Scopus)