研究成果の検索

検索コンセプト
選択されたフィルター

出版年

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

著者

  • Yusaku Nakabeppu

What have we learned from cultured adult dorsal root ganglion neurons?

Sango, K., Niimi, N., Tsukamoto, M., Utsunomiya, K., Sakumi, K., Nakabeppu, Y., Kadoya, T. & Horie, H., 1 1 2014, Ganglion Cells: Morphology, Functional Development and Role in Disease. Nova Science Publishers, Inc., p. 125-148 24 p.

研究成果: 著書/レポートタイプへの貢献

Therapeutic effects of hydrogen in animal models of Parkinson's disease

Fujita, K., Nakabeppu, Y. & Noda, M., 9 19 2011, : : Parkinson's Disease. 307875.

研究成果: ジャーナルへの寄稿評論記事

10 引用 (Scopus)
29 引用 (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., 5 1 2018, : : Neuroscience. 377, p. 87-97 11 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Bjørge, M. D., Hildrestrand, G. A., Scheffler, K., Suganthan, R., Rolseth, V., Kuśnierczyk, A., Rowe, A. D., Vågbø, C. B., Vetlesen, S., Eide, L., Slupphaug, G., Nakabeppu, Y., Bredy, T. W., Klungland, A. & Bjørås, M., 12 29 2015, : : Cell Reports. 13, 12, p. 2671-2678 8 p.

研究成果: ジャーナルへの寄稿記事

公開
17 引用 (Scopus)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., 2 17 2017, : : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Skin tumours induced by narrowband UVB have higher frequency of p53 mutations than tumours induced by broadband UVB independent of Ogg1 genotype

Yogianti, F., Kunisada, M., Ono, R., Sakumi, K., Nakabeppu, Y. & Nishigori, C., 11 1 2012, : : Mutagenesis. 27, 6, p. 637-643 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Silencing of SNX1 by siRNA stimulates the ligand-induced endocytosis of EGFR and increases EGFR phosphorylation in gefitinib-resistant human lung cancer cell lines

Nishimura, Y., Takiguchi, S., Yoshioka, K., Nakabeppu, Y. & Itoh, K., 10 1 2012, : : International journal of oncology. 41, 4, p. 1520-1530 11 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation

Kajitani, K., Yanagimoto, K. & Nakabeppu, Y., 10 1 2017, : : Psychopharmacology. 234, 19, p. 2919-2927 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes

Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., 10 2017, : : DNA Repair. 58, p. 13-20 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., 1 1 2017, : : Cancer Medicine. 6, 1, p. 258-266 9 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., 10 1 2016, : : Genes to Cells. 21, 10, p. 1030-1048 19 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

Tsuzuki, T., Piao, J. S., Isoda, T., Sakumi, K., Nakabeppu, Y. & Nakatsu, Y., 3 1 2011, : : Health physics. 100, 3, p. 293-294 2 p.

研究成果: ジャーナルへの寄稿Conference article

1 引用 (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M. & Nakaya, H., 11 29 2013, : : Scientific reports. 3, 3273.

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., 1 1 2020, : : PloS one. 15, 1, e0227501.

研究成果: ジャーナルへの寄稿記事

公開

Nucleotides function as endogenous chemical sensors for oxidative stress signaling

Ihara, H., Sawa, T., Nakabeppu, Y. & Akaike, T., 1 1 2011, : : Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 33-39 7 p.

研究成果: ジャーナルへの寄稿評論記事

9 引用 (Scopus)

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., 10 1 2016, : : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Neuroendocrine phenotypes in a boy with 5q14 deletion syndrome implicate the regulatory roles of myocyte-specific enhancer factor 2C in the postnatal hypothalamus

Sakai, Y., Ohkubo, K., Matsushita, Y., Akamine, S., Ishizaki, Y., Torisu, H., Ihara, K., Sanefuji, M., Kim, M. S., Lee, K. U., Shaw, C. A., Lim, J., Nakabeppu, Y. & Hara, T., 9 1 2013, : : European Journal of Medical Genetics. 56, 9, p. 475-483 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.

Nakabeppu, Y., 4 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.

研究成果: 著書/レポートタイプへの貢献

Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice

Tsuji, H., Ishii-Ohba, H., Shiomi, T., Shiomi, N., Katsube, T., Mori, M., Nenoi, M., Ohno, M., Yoshimura, D., Oka, S., Nakabeppu, Y., Tatsumi, K., Muto, M. & Sado, T., 5 1 2013, : : Journal of radiation research. 54, 3, p. 453-466 14 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 9 22 2016, : : JCI insight. 1, 15, 15 p., e87781.

研究成果: ジャーナルへの寄稿記事

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 1 1 2016, : : JCI Insight. 1, 15, e87781.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

Oka, S., Leon, J., Tsuchimoto, D., Sakumi, K. & Nakabeppu, Y., 1 1 2014, : : Oncogenesis. 3, 10, e121.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

Murakami, Y., Ikeda, Y., Yoshida, N., Notomi, S., Hisatomi, T., Oka, S., De Luca, G., Yonemitsu, Y., Bignami, M., Nakabeppu, Y. & Ishibashi, T., 10 1 2012, : : American Journal of Pathology. 181, 4, p. 1378-1386 9 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E. & Abolhassani, N., 6 1 2017, : : Free Radical Biology and Medicine. 107, p. 151-158 8 p.

研究成果: ジャーナルへの寄稿評論記事

20 引用 (Scopus)

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., 1 15 2017, : : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes

Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K. & Kitazono, T., 1 1 2014, : : Arteriosclerosis, thrombosis, and vascular biology. 34, 1, p. 44-51 8 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

International symposium on “germline mutagenesis and Biodiversification”

Uchimura, A., Hara, Y., Gondo, Y. & Nakabeppu, Y., 9 1 2014, : : Genes and Genetic Systems. 89, 2, p. 93-95 3 p.

研究成果: ジャーナルへの寄稿編集

Inhibitory effects of dietary spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis

Yogianti, F., Kunisada, M., Nakano, E., Ono, R., Sakumi, K., Oka, S., Nakabeppu, Y. & Nishigori, C., 1 1 2014, : : Journal of Investigative Dermatology. 134, 10, p. 2610-2619 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis

Kunisada, M., Yogianti, F., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 12 1 2011, : : American Journal of Pathology. 179, 6, p. 3056-3065 10 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 3 10 2016, : : Scientific reports. 6, 22991.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., 11 29 2016, : : Scientific reports. 6, 37889.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

Takaku, S., Yanagisawa, H., Watabe, K., Horie, H., Kadoya, T., Sakumi, K., Nakabeppu, Y., Poirier, F. & Sango, K., 2 1 2013, : : Neurochemistry International. 62, 3, p. 330-339 10 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice

Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., 2 1 2015, : : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., 6 5 2016, : : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

研究成果: ジャーナルへの寄稿評論記事

公開

FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 4 1 2013, : : Neuropsychopharmacology. 38, 5, p. 895-906 12 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔfosB

Ohnishi, Y. N., Ohnishi, Y. H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Kunihiko, S., Nestler, E. J. & Nakabeppu, Y., 9 1 2011, : : Biological Psychiatry. 70, 5, p. 487-495 9 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J. & Nakabeppu, Y., 8 2014, : : GLIA. 62, 8, p. 1284-1298 15 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., 11 2017, : : Pathology International. 67, 11, p. 564-574 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., 6 2018, : : Neuropathology. 38, 3, p. 247-259 13 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)
3 引用 (Scopus)

Erratum: FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)

Yutsudo, N., Kamada, T., Kajitani, K., Nomaru, H., Katogi, A., Ohnishi, Y. H., Ohnishi, Y. N., Takase, K. I., Sakumi, K., Shigeto, H. & Nakabeppu, Y., 6 1 2013, : : Neuropsychopharmacology. 38, 7, p. 1374-1375 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 6 10 2016, : : Scientific reports. 6, 27164.

研究成果: ジャーナルへの寄稿コメント/討論

Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., 3 23 2015, : : Nucleic acids research. 43, 7, p. 3870-3871 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

2 引用 (Scopus)

Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains

Hamasaki, H., Honda, H., Suzuki, S. O., Hokama, M., Kiyohara, Y., Nakabeppu, Y. & Iwaki, T., 6 2014, : : Neuropathology. 34, 3, p. 284-290 7 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)
44 引用 (Scopus)