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• Review article

  Abnormal myocardial contractile regulation mechanism in familial hypertrophic and dilated cardiomyopathies--functional analysis of molecular mutant troponin in in-vitro

  Morimoto, S., 1 2002, In: Fukuoka igaku zasshi = Hukuoka acta medica. 93, 1, p. 1-5 5 p.

  研究成果: Contribution to journal › Review article › 査読
  1 被引用数 (Scopus)

• Abnormal peripheral circulation in patients with heart failure

  Kishi, T. & Hirooka, Y., 4 28 2007, In: Nippon rinsho. Japanese journal of clinical medicine. 65 Suppl 4, p. 316-320 5 p.

  研究成果: Contribution to journal › Review article › 査読

• A case of hepatocellular carcinoma with right atrium tumor thrombus and multiple intrahepatic metastases that remarkably responded to combination therapy including surgery

  Otsuru, T., Kobayashi, S., Eguchi, H., Wada, H., Iwagami, Y., Yamada, D., Asaoka, T., Noda, T., Gotoh, K., Umeshita, K., Doki, Y. & Mori, M., 1 2018, In: Japanese Journal of Cancer and Chemotherapy. 45, 1, p. 187-189 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Heart Atria
  • Hepatocellular Carcinoma
  • Thrombosis
  • Neoplasm Metastasis
  • Neoplasms

• A case of rectal cancer with multiple pulmonary and liver metastases could be resected through chemotherapy

  Nomura, M., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Matsuda, C., Yamamoto, H., Mizushima, T., Doki, Y. & Mori, M., 1 2018, In: Japanese Journal of Cancer and Chemotherapy. 45, 1, p. 169-171 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Rectal Neoplasms
  • Bevacizumab
  • Neoplasm Metastasis
  • Drug Therapy
  • Prostate

• A case of repeated surgical resections for tumor seeding of hepatocellular carcinoma after radiof requency ablation

  Fukuda, Y., Asaoka, T., Eguchi, H., Iwagami, Y., Yamada, D., Noda, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Doki, Y. & Mori, M., 2 2018, In: Japanese Journal of Cancer and Chemotherapy. 45, 2, p. 342-344 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Radiofrequency Ablation
  • Hepatocellular Carcinoma
  • Neoplasms
  • Recurrence
  • Segmental Mastectomy
  1 被引用数 (Scopus)

• A case of resection for lymph node recurrence around the inferior vena cava after radical surgery of undifferentiated carcinoma of the pancreatic head region

  Kubo, M., Yamada, D., Eguchi, H., Iwagami, Y., Noda, T., Asaoka, T., Wada, H., Kawamoto, K., Gotoh, K., Kobayashi, S., Mori, M. & Doki, Y., 2 2018, In: Japanese Journal of Cancer and Chemotherapy. 45, 2, p. 359-361 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Inferior Vena Cava
  • Lymph Nodes
  • Carcinoma
  • Recurrence
  • Neoplasms

• A Case of SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) Syndrome Complicated by Sweet's Disease

  Wada, N., Maehara, E., Ohno, F., Takamatsu, H., Harada, K. & Urabe, K., 1 1 2015, In: Nishinihon Journal of Dermatology. 77, 4, p. 345-348 4 p.

  研究成果: Contribution to journal › Review article › 査読

  • Sweet Syndrome
  • Hyperostosis
  • Osteitis
  • Synovitis
  • Acne Vulgaris

• A case of successfully treated Japanese spotted fever with earlyintervention: A literature review and analysis of a case series on effective clinical symptoms that help early diagnosis and treatment

  Kuretake, K., Oda, M., Takeuchi, S., Matsuda, T. & Furue, M., 2019, In: Nishinihon Journal of Dermatology. 81, 5, p. 405-412 8 p.

  研究成果: Contribution to journal › Review article › 査読

  • Spotted Fever Group Rickettsiosis
  • Erythema
  • Early Diagnosis
  • Axilla
  • Fever

• A CASE of UPSIDE-DOWN STOMACH ACCOMPANIED by ACUTE NECROTIZING ESOPHAGITIS

  Kai, T., Hizawa, K., Ihara, Y., Fujita, K., Iida, M., Washio, E., Esaki, M. & Iida, M., 7 2017, In: GASTROENTEROLOGICAL ENDOSCOPY. 59, 7, p. 1482-1486 5 p.

  研究成果: Contribution to journal › Review article › 査読

  • Esophagus
  • Duodenoscopes
  • Stomach Volvulus
  • Stomach
  • Intestinal Volvulus

• A case report of complete resection of the recurrence small intestinal carcinoma with abdominal wall repair using femoral fascia

  Fukata, T., Hata, T., Kubo, T., Haraguchi, N., Takahashi, H., Nishimura, J., Matsuda, C., Mizushima, T., Hosokawa, K., Doki, Y. & Mori, M., 4 2018, In: Japanese Journal of Cancer and Chemotherapy. 45, 4, p. 661-663 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Fascia
  • Abdominal Wall
  • Thigh
  • Colon
  • Carcinoma

• A case showing a blistering disorder in radiation dermatitis during radiation therapy

  Nonoshita, T., Nakamura, K., Shioyama, Y., Nomoto, S., Ooga, S., Yoshitake, T., Toba, T., Kunitake, N., Terashima, H. & Honda, H., 6 2007, In: Journal of JASTRO. 19, 2, p. 123-125 3 p.

  研究成果: Contribution to journal › Review article › 査読

  • Radiodermatitis
  • Thymus Neoplasms
  • Blister
  • Radiation
  • Steroids

• Accessory left gastric artery from left hepatic artery shown on MDCT and conventional angiography: Correlation with CT hepatic arteriography

  Ishigami, K., Yoshimitsu, K., Irie, H., Tajima, T., Asayama, Y., Hirakawa, M. & Honda, H., 10 2006, In: American Journal of Roentgenology. 187, 4, p. 1002-1009 8 p.

  研究成果: Contribution to journal › Review article › 査読

  • Gastric Artery
  • Hepatic Artery
  • Angiography
  • Liver
  • Sensitivity and Specificity
  21 被引用数 (Scopus)

• Acclimative response to temperature stress in higher plants: Approaches of gene engineering for temperature tolerance

  Iba, K., 2002, In: Annual Review of Plant Biology. 53, p. 225-245 21 p.

  研究成果: Contribution to journal › Review article › 査読

  • Plant Genes
  • engineering
  • Temperature
  • temperature
  • genes
  456 被引用数 (Scopus)

• Accurate calculation of core-electron binding energies: Multireference perturbation treatment

  Shirai, S., Yamamoto, S. & Hyodo, S. A., 10 22 2004, In: Journal of Chemical Physics. 121, 16, p. 7586-7594 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • Binding energy
  • Electron correlations
  • binding energy
  • Excited states
  • Electrons
  20 被引用数 (Scopus)

• Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung’s disease

  Yoshimaru, K., Yanagi, Y., Obata, S., Takahashi, Y., Irie, K., Omori, A., Matsuura, T. & Taguchi, T., 2 2021, In: Surgery today. 51, 2, p. 181-186 6 p.

  研究成果: Contribution to journal › Review article › 査読

  • Hirschsprung Disease
  • Acetylcholinesterase
  • Staining and Labeling
  • rubeanic acid
  • Acetylcholine

• Achieving high strength and high ductility in precipitation-hardened alloys

  Horita, Z., Ohashi, K., Fujita, T., Kaneko, K. & Langdon, T. G., 7 4 2005, In: Advanced Materials. 17, 13, p. 1599-1602 4 p.

  研究成果: Contribution to journal › Review article › 査読

  • Ductility
  • Metastable phases
  • Silver alloys
  • Ultrafine
  • Stress-strain curves
  242 被引用数 (Scopus)

• A collaborative platform for sustainable building design based on model integration over the internet

  Kraines, S., Koyama, M., Weber, C., Ikaga, T., Chikamoto, T., Wallace, D. & Komiyama, H., 2005, In: International Journal of Environmental Technology and Management. 5, 2-3, p. 135-161 27 p.

  研究成果: Contribution to journal › Review article › 査読

  • architectural design
  • Internet
  • demolition
  • pollutant emission
  • energy use
  3 被引用数 (Scopus)

• A comparison of DAI scores and characteristics of occlusal traits in three ethnic groups of Asian origin

  Katoh, Y., Ansai, T., Takehara, T., Yamashita, Y., Miyazaki, H., Jenny, J. & Cons, N. C., 8 1998, In: International Dental Journal. 48, 4, p. 405-411 7 p.

  研究成果: Contribution to journal › Review article › 査読

  • Dental Esthetics
  • Malocclusion
  • European Continental Ancestry Group
  • North American Indians
  • Taiwan
  23 被引用数 (Scopus)

• A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens

  Kashiwazaki, H., Matsushita, T., Sugita, J., Shigematsu, A., Kasashi, K., Yamazaki, Y., Kanehira, T., Kondo, T., Endo, T., Tanaka, J., Hashino, S., Nishio, M., Imamura, M., Kitagawa, Y. & Inoue, N., 5 2012, In: Supportive Care in Cancer. 20, 5, p. 933-939 7 p.

  研究成果: Contribution to journal › Review article › 査読

  • Stomatitis
  • Hematopoietic Stem Cell Transplantation
  • Stem Cell Transplantation
  • Opioid Analgesics
  • Pain
  12 被引用数 (Scopus)

• A comparison of postoperative quality of life and dysfunction after Billroth i and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer: Results from a multi-institutional RCT

  Takiguchi, S., Yamamoto, K., Hirao, M., Imamura, H., Fujita, J., Yano, M., Kobayashi, K., Kimura, Y., Kurokawa, Y., Mori, M. & Doki, Y., 4 2012, In: Gastric Cancer. 15, 2, p. 198-205 8 p.

  研究成果: Contribution to journal › Review article › 査読

  • Gastroenterostomy
  • Gastrectomy
  • Stomach Neoplasms
  • Quality of Life
  • Postal Service
  60 被引用数 (Scopus)

• A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases

  Saruwatari, T., Praseuth, A. P., Sato, M., Torikai, K., Noguchi, H. & Watanabe, K., 1 2011, In: Journal of Antibiotics. 64, 1, p. 9-17 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • Polyketide Synthases
  • Polyketides
  • hypothemycin
  • bikaverin
  • Lactones
  8 被引用数 (Scopus)

• A comprehensive screening system for damaged nucleotide-binding proteins

  Tsuchimoto, D., Iyama, T., Nonaka, M., Abolhassani, N., Ohta, E., Sakumi, K. & Nakabeppu, Y., 11 28 2010, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 37-42 6 p.

  研究成果: Contribution to journal › Review article › 査読

  • Inosine Triphosphate
  • Carrier Proteins
  • Nucleotides
  • 2'-deoxycytidine 5'-triphosphate
  • inosine triphosphatase
  8 被引用数 (Scopus)

• A consideration on the effects of drag force acting on roughness element - The relationship between drag coefficient and dissipation rate

  Ikegaya, N., Hagishima, A. & Tanimoto, J., 1 1 2014, In: Journal of Environmental Engineering (Japan). 79, 697, p. 297-304 8 p.

  研究成果: Contribution to journal › Review article › 査読

  • Budgets
  • Drag coefficient
  • Momentum
  • Drag
  • Surface roughness

• Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutationdiversity, ductility, and destiny

  Suda, K., Mizuuchi, H., Maehara, Y. & Mitsudomi, T., 12 2012, In: Cancer and Metastasis Reviews. 31, 3-4, p. 807-814 8 p.

  研究成果: Contribution to journal › Review article › 査読

  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Lung Neoplasms
  • Mutation
  • erbB-1 Genes
  105 被引用数 (Scopus)

• A critical review of research methods of Western human geography: A combination of knowing and doing for Chinese human geography

  Liu, Y., Li, Z. & Li, B., 8 1 2014, In: Dili Xuebao/Acta Geographica Sinica. 69, 8, p. 1224-1233 10 p.

  研究成果: Contribution to journal › Review article › 査読

  • human geography
  • research method
  • imitation
  • geography
  • innovation
  4 被引用数 (Scopus)

• A critical role of the CDM family molecule DOCK2 in lymphocyte migration

  Fukui, Y., 1 1 2002, In: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47, 16 Suppl, p. 2194-2199 6 p.

  研究成果: Contribution to journal › Review article › 査読

• A crucial review on recent updates of oxidation behavior in high entropy alloys

  Anne, B. R., Shaik, S., Tanaka, M. & Basu, A., 3 2021, In: SN Applied Sciences. 3, 3, 366.

  研究成果: Contribution to journal › Review article › 査読

  Open Access

  • High-entropy alloys
  • entropy
  • Oxidation
  • oxidation
  • thermal fatigue

• Action of clostridial neurotoxins and mechanism of the membrane fusion of intracellular transport vesicles

  Hayashi, T., 7 1997, In: Nippon saikingaku zasshi. Japanese journal of bacteriology. 52, 3, p. 583-592 10 p.

  研究成果: Contribution to journal › Review article › 査読
  1 被引用数 (Scopus)

• Activation of the FA pathway mediated by phosphorylation and ubiquitination

  Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., 10 2017, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

  研究成果: Contribution to journal › Review article › 査読

  • Fanconi Anemia
  • Ubiquitination
  • Phosphorylation
  • Fanconi Anemia Complementation Group D2 Protein
  • Bone Marrow Cells
  10 被引用数 (Scopus)

• Activations of the Ca dependent K channel by Ca released from the sarcoplasmic reticulum of mammalian smooth muscles

  Kitamura, K., Sakai, T., Kajioka, S. & Kuriyama, H., 1989, In: Biomedica Biochimica Acta. 48, 5-6, p. S364-S369

  研究成果: Contribution to journal › Review article › 査読

  • Sarcoplasmic Reticulum
  • Clamping devices
  • Depolarization
  • Muscle
  • Chemical activation
  12 被引用数 (Scopus)

• Active oligonucleotides incorporating alkylating an agent as potential sequence- and base selective modifier of gene expression

  Sasaki, S., 2001, In: European Journal of Pharmaceutical Sciences. 13, 1, p. 43-51 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • 2-amino-6-vinylpurine
  • Modifier Genes
  • Alkylating Agents
  • Efficiency
  • Oligonucleotides
  19 被引用数 (Scopus)

• Acute adrenocortical insufficiency

  Ohnaka, K. & Takayanagi, R., 5 28 2006, In: Nippon rinsho. Japanese journal of clinical medicine. Suppl 1, p. 559-561 3 p.

  研究成果: Contribution to journal › Review article › 査読

• Acute and Chronic Effects of Cancer Drugs on the Cardiovascular System

  Moriyama, S., Fukata, M., Kusaba, H., Maruyama, T. & Akashi, K., 4 2020, In: Heart Failure Clinics. 16, 2, p. 231-241 11 p.

  研究成果: Contribution to journal › Review article › 査読

  • Cardiotoxicity
  • Cardiovascular System
  • Heart Failure
  • Pharmaceutical Preparations
  • Trastuzumab

• Acute autonomic neuropathy and the other related diseases

  Shimoda, S., Ishibashi, H. & Niho, Y., 4 1992, In: Nippon rinsho. Japanese journal of clinical medicine. 50, 4, p. 852-857 6 p.

  研究成果: Contribution to journal › Review article › 査読

  • Primary Dysautonomias
  • Parasympathetic Nervous System
  • Sympathetic Nervous System
  • Neurologic Manifestations
  • Cholinergic Agents
  1 被引用数 (Scopus)

• Acute Decompensated Heart Failure in Patients with Heart Failure with Reduced Ejection Fraction

  Fukata, M., 4 2020, In: Heart Failure Clinics. 16, 2, p. 187-200 14 p.

  研究成果: Contribution to journal › Review article › 査読

  • Heart Failure
  • Stroke Volume
  • Pulmonary Edema
  • Renin-Angiotensin System
  • Vasodilator Agents
  1 被引用数 (Scopus)

• Acute lymphoblastic leukemia with p190 type bcr/abl chimeric mRNA at relapse

  Choi, I., Matsushima, T., Fujii, T., Shiratsuchi, M., Abe, Y., Nishimura, J., Nawata, H. & Muta, K., 9 2002, In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 43, 9, p. 836-840 5 p.

  研究成果: Contribution to journal › Review article › 査読

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Philadelphia Chromosome
  • Recurrence
  • Messenger RNA
  • abl Genes

• Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: A case report and review of the literature

  Shimonodan, H., Nagayama, J., Nagatoshi, Y., Hatanaka, M., Takada, A., Iguchi, H., Oda, Y. & Okamura, J., 9 1 2005, In: Pediatric Blood and Cancer. 45, 3, p. 333-339 7 p.

  研究成果: Contribution to journal › Review article › 査読

  • peptide A
  • Parathyroid Hormone-Related Protein
  • Hypercalcemia
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Serum
  38 被引用数 (Scopus)

• Acute myelitis in a patient with ulcerative colitis

  Hagiwara, K., Ochi, H., Murai, H., Shigeto, H., Ohyagi, Y. & Kira, J. I., 8 10 2007, In: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 96, 8, p. 1703-1705 3 p.

  研究成果: Contribution to journal › Review article › 査読

• Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts

  Peterson, L. F., Boyapati, A., Ahn, E. Y., Biggs, J. R., Akiko, J. O., Lo, M. C., Yan, M. & Zhang, D. E., 8 1 2007, In: Blood. 110, 3, p. 799-805 7 p.

  研究成果: Contribution to journal › Review article › 査読

  • Genetic Translocation
  • Chromosomes
  • Acute Myeloid Leukemia
  • Genes
  • Chromosomes, Human, Pair 8
  88 被引用数 (Scopus)

• Acute respiratory distress syndrome after pulmonary resection

  Kometani, T., Okamoto, T., Yoshida, S. & Yoshino, I., 9 2013, In: General thoracic and cardiovascular surgery. 61, 9, p. 504-512 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • Adult Respiratory Distress Syndrome
  • Lung
  • Mortality
  • Pulmonary Wedge Pressure
  • Pulmonary Edema
  13 被引用数 (Scopus)

• Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms

  Yamashita, A., Hayashi, Y., Nemoto-Sasaki, Y., Ito, M., Oka, S., Tanikawa, T., Waku, K. & Sugiura, T., 2014, In: Progress in Lipid Research. 53, 1, p. 18-81 64 p.

  研究成果: Contribution to journal › Review article › 査読

  • Acyltransferases
  • Metabolism
  • Coenzyme A
  • Cells
  • Lipid Metabolism
  116 被引用数 (Scopus)

• Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function

  Morohashi, K. I. & Omura, T., 12 1996, In: FASEB Journal. 10, 14, p. 1569-1577 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • Steroidogenic Factor 1
  • Transcription
  • Cytochrome P-450 Enzyme System
  • Genes
  • Transcription Factors
  183 被引用数 (Scopus)

• Ad4BP/SF-1 and sex differentiation of the gonads

  Morohashi, K. & Nomura, M., 6 1996, In: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 41, 8 Suppl, p. 1033-1041 9 p.

  研究成果: Contribution to journal › Review article › 査読

• Adaptive response: Induced synthesis of DNA repair enzymes by alkylating agents

  Sekiguchi, M. & nakabeppu, Y., 1987, In: Trends in Genetics. 3, C, p. 51-54 4 p.

  研究成果: Contribution to journal › Review article › 査読

  • DNA Repair Enzymes
  • Alkylating Agents
  • Alkylation
  • Enzymes
  • Escherichia coli
  51 被引用数 (Scopus)

• Adaptive self-assembly of coordination nanoparticles formed in aqueous media and their functions

  Nishiyabu, R. & Kimizuka, N., 6 2011, In: Kobunshi. 60, 6, p. 386-389 4 p.

  研究成果: Contribution to journal › Review article › 査読

  • Self assembly
  • Nanoparticles
  • Lanthanoid Series Elements
  • Rare earth elements
  • Proteins

• A delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) and intradermal hepatitis B vaccination.

  Nagafuchi, S., Kashiwagi, S., Hayashi, J., Katsuta, H., Ikematsu, H. & Harada, M., 12 2004, In: Fukuoka igaku zasshi = Hukuoka acta medica. 95, 12, p. 305-313 9 p.

  研究成果: Contribution to journal › Review article › 査読

  • Delayed Hypersensitivity
  • Hepatitis B Surface Antigens
  • Hepatitis B
  • Vaccination
  • Skin
  2 被引用数 (Scopus)

• Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function: Role of nitric oxide and Rho-kinase

  Hirooka, Y., 2004, In: Progress in Biophysics and Molecular Biology. 84, 2-3, p. 233-249 17 p.

  研究成果: Contribution to journal › Review article › 査読

  • rho-Associated Kinases
  • Adenoviridae
  • Brain Stem
  • Solitary Nucleus
  • Nitric Oxide
  8 被引用数 (Scopus)

• Adenovirus serotype 31 infection in a newborn girl and review of the literature

  Fukuda, S., Ogiso, K., Mushimoto, Y., Abe, M., Yasuda, K. & Yamaguchi, S., 6 2011, In: Pediatrics International. 53, 3, p. 408-411 4 p.

  研究成果: Contribution to journal › Review article › 査読
  2 被引用数 (Scopus)

• A depressive disorder in patients with irritable bowel syndrome and non-ulcer dyspepsia

  Mine, K., Kanazawa, F., Matsumoto, K., Tsuchida, O., Hosoi, M. & Kubo, C., 5 1994, In: Nippon rinsho. Japanese journal of clinical medicine. 52, 5, p. 1329-1333 5 p.

  研究成果: Contribution to journal › Review article › 査読

  • Dyspepsia
  • Irritable Bowel Syndrome
  • Depressive Disorder
  • Digestive System
  • Psychiatry
  5 被引用数 (Scopus)

• Adipokines: Therapeutic targets for metabolic syndrome

  Kobayashi, K. & Inoguchi, T., 6 2005, In: Current Drug Targets. 6, 4, p. 525-529 5 p.

  研究成果: Contribution to journal › Review article › 査読

  • Adipokines
  • Lipid Metabolism
  • Metabolic Syndrome
  • Insulin Resistance
  • Biomolecules
  60 被引用数 (Scopus)