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  • Hiroyuki Kitao
2018

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., 7 6 2018, : : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Inoue, Y., Yamashita, N., Kitao, H., Tanaka, K., Saeki, H., Oki, E., Oda, Y., Tokunaga, E. & Maehara, Y., 8 2018, : : Clinical Breast Cancer. 18, 4, p. e643-e650

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., 2 1 2018, : : Cancer Science. 109, 2, p. 264-271 8 p.

研究成果: ジャーナルへの寄稿評論記事

9 引用 (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., 10 2018, : : Clinical Breast Cancer. 18, 5, p. e1003-e1009

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., 12 1 2018, : : Scientific reports. 8, 1, 10888.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 10 2018, : : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)
2017

Activation of the FA pathway mediated by phosphorylation and ubiquitination

Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., 10 2017, : : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

研究成果: ジャーナルへの寄稿評論記事

7 引用 (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Ando, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16762.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16969.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., 1 1 2017, : : Cancer Medicine. 6, 1, p. 258-266 9 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
2016

Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)

Kitao, H., Matsuoka, K., Iimori, M., Tokunaga, E., Saeki, H., Oki, E., Miyamoto, Y., Baba, H. & Maehara, Y., 1 1 2016, : : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 8-14 7 p.

研究成果: ジャーナルへの寄稿評論記事

Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer

Tokunaga, E., Yamashita, N., Kitao, H., Tanaka, K., Taketani, K., Inoue, Y., Saeki, H., Oki, E., Oda, Y. & Maehara, Y., 2 1 2016, : : Breast. 25, p. 62-68 7 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers

Maehara, Y., Oki, E., Saeki, H., Tokunaga, E., Kitao, H., Iimori, M., Niimi, S., Kataoka, Y., Emi, Y., Kakeji, Y., Baba, H. & Shirasaka, T., 7 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 7, p. 845-854 10 p.

研究成果: ジャーナルへの寄稿評論記事

Expression of APOBEC3B mRNA in primary breast cancer of Japanese women

Tokunaga, E., Yamashita, N., Tanaka, K., Inoue, Y., Akiyoshi, S., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 12 2016, : : PloS one. 11, 12, e0168090.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Ito, S., Okano, S., Morita, M., Saeki, H., Tsutsumi, S., Tsukihara, H., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Kitao, H., Mimori, K. & Maehara, Y., 8 1 2016, : : Annals of Surgical Oncology. 23, p. 508-515 8 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis

Otsu, H., Iimori, M., Ando, K., Saeki, H., Aishima, S., Oda, Y., Morita, M., Matsuo, K., Kitao, H., Oki, E. & Maehara, Y., 7 1 2016, : : Oncology (Switzerland). 91, 1, p. 31-40 10 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer

Sugiyama, M., Oki, E., Nakaji, Y., Tsutsumi, S., Ono, N., Nakanishi, R., Sugiyama, M., Nakashima, Y., Sonoda, H., Ohgaki, K., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Morita, M., Oda, Y. & Maehara, Y., 11 1 2016, : : Cancer Science. 107, 11, p. 1705-1716 12 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Impact of Expression of Vimentin and Axl in Breast Cancer

Tanaka, K., Tokunaga, E., Inoue, Y., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Oki, E., Oda, Y. & Maehara, Y., 12 1 2016, : : Clinical Breast Cancer. 16, 6, p. 520-526.e2

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Oxaliplatin - A 10-year trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., 6 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 715-722 8 p.

研究成果: ジャーナルへの寄稿評論記事

Oxaliplatin -- A 10-Year Trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., 6 1 2016, : : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 715-722 8 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Iimori, M., Watanabe, S., Kiyonari, S., Matsuoka, K., Sakasai, R., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 3 31 2016, : : Nature communications. 7, 11117.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Kitao, H., Morodomi, Y., Niimi, S., Kiniwa, M., Shigeno, K., Matsuoka, K., Kataoka, Y., Iimori, M., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., 5 3 2016, : : Scientific reports. 6, 25286.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Kitao, H., Kiyonari, S., Limori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., 6 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 707-714 8 p.

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU

Kitao, H., Kiyonari, S., Iimori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., 6 1 2016, : : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 707-714 8 p.

研究成果: ジャーナルへの寄稿記事

2015

Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer

Ando, K., Oki, E., Saeki, H., Yan, Z., Tsuda, Y., Hidaka, G., Kasagi, Y., Otsu, H., Kawano, H., Kitao, H., Morita, M. & Maehara, Y., 1 1 2015, : : Cancer Medicine. 4, 1, p. 75-83 9 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Epigenetic inactivation of BRCA1 through promoter hypermethylation and its clinical importance in triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hitchins, M., Inoue, Y., Tanaka, K., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Oda, Y., Saeki, H., Oki, E. & Maehara, Y., 12 2015, : : Clinical Breast Cancer. 15, 6, p. 498-504 7 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Intensive immunofluorescence staining methods for low expression protein: Detection of intestinal stem cell marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., 10 29 2015, : : Acta Histochemica et Cytochemica. 48, 5, p. 159-164 6 p.

研究成果: ジャーナルへの寄稿コメント/討論

3 引用 (Scopus)

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis

Kiyonari, S., Iimori, M., Matsuoka, K., Watanabe, S., Morikawa-Ichinose, T., Miura, D., Niimi, S., Saeki, H., Tokunaga, E., Oki, E., Morita, M., Kadomatsu, K., Maehara, Y. & Kitao, H., 10 1 2015, : : Molecular Cancer Therapeutics. 14, 10, p. 2332-2342 11 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks

Matsuoka, K., Iimori, M., Niimi, S., Tsukihara, H., Watanabe, S., Kiyonari, S., Kiniwa, M., Ando, K., Tokunaga, E., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., 1 1 2015, : : Molecular Cancer Therapeutics. 14, 4, p. 1004-1013 10 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)
2014

Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer

Zhao, Y., Ando, K., Oki, E., Ikawa-Yoshida, A., Ida, S., Kimura, Y., Saeki, H., Kitao, H., Morita, M. & Maehara, Y., 10 1 2014, : : Anticancer research. 34, 10, p. 5421-5427 7 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Chromosomal Instability Associated with Global DNA Hypomethylation is Associated with the Initiation and Progression of Esophageal Squamous Cell Carcinoma

Kawano, H., Saeki, H., Kitao, H., Tsuda, Y., Otsu, H., Ando, K., Ito, S., Egashira, A., Oki, E., Morita, M., Oda, Y. & Maehara, Y., 1 1 2014, : : Annals of Surgical Oncology. 21, 4, p. 696-702 7 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers

Honma, K., Nakanishi, R., Nakanoko, T., Ando, K., Saeki, H., Oki, E., Iimori, M., Kitao, H., Kakeji, Y. & Maehara, Y., 3 1 2014, : : Surgery today. 44, 3, p. 454-461 8 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Molecular mechanisms regulating the hormone sensitivity of breast cancer

Tokunaga, E., Hisamatsu, Y., Tanaka, K., Yamashita, N., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 11 1 2014, : : Cancer Science. 105, 11, p. 1377-1383 7 p.

研究成果: ジャーナルへの寄稿評論記事

16 引用 (Scopus)

Mortalin is a prognostic factor of gastric cancer with normal p53 function

Ando, K., Oki, E., Zhao, Y., Ikawa-Yoshida, A., Kitao, H., Saeki, H., Kimura, Y., Ida, S., Morita, M., Kusumoto, T. & Maehara, Y., 4 2014, : : Gastric Cancer. 17, 2, p. 255-262 8 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer

Tokunaga, E., Nakashima, Y., Yamashita, N., Hisamatsu, Y., Okada, S., Akiyoshi, S., Aishima, S., Kitao, H., Morita, M. & Maehara, Y., 5 2014, : : Breast Cancer. 21, 3, p. 341-349 9 p.

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

Oxidative DNA damage in human esophageal cancer: Clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme

Kubo, N., Morita, M., Nakashima, Y., Kitao, H., Egashira, A., Saeki, H., Oki, E., Kakeji, Y., Oda, Y. & Maehara, Y., 4 2014, : : Diseases of the Esophagus. 27, 3, p. 285-293 9 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)
2013

Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells

Ikawa-Yoshida, A., Ando, K., Oki, E., Saeki, H., Kumashiro, R., Taketani, K., Ida, S., Tokunaga, E., Kitao, H., Morita, M. & Maehara, Y., 8 2013, : : Cancer Medicine. 2, 4, p. 447-456 10 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Involvement of ribonucleotide reductase-M1 in 5-fluorouracil.-induced DNA damage in esophageal cancer cell lines

Aoki, Y., Sakogawa, K., Hihara, J., Emi, M., Hamai, Y., Kono, K., Shi, L., Sun, J., Kitao, H., Ikura, T., Niida, H., Nakanishi, M., Okada, M. & Tashiro, S., 6 1 2013, : : International journal of oncology. 42, 6, p. 1951-1960 10 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

Nakashima, Y., Yoshinaga, K., Kitao, H., Ando, K., Kimura, Y., Saeki, H., Oki, E., Morita, M., Kakeji, Y., Hirahashi, M., Oda, Y. & Maehara, Y., 12 1 2013, : : Cancer Science. 104, 12, p. 1718-1725 8 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer

Nakanishi, R., Harada, J., Tuul, M., Zhao, Y., Ando, K., Saeki, H., Oki, E., Ohga, T., Kitao, H., Kakeji, Y. & Maehara, Y., 12 1 2013, : : International Journal of Clinical Oncology. 18, 6, p. 1042-1048 7 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Tuul, M., Kitao, H., Iimori, M., Matsuoka, K., Kiyonari, S., Saeki, H., Oki, E., Morita, M. & Maehara, Y., 2 1 2013, : : PloS one. 8, 2, e55361.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Vimentin as a poor prognostic factor for triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Aishima, S., Morita, M. & Maehara, Y., 5 1 2013, : : Journal of Cancer Research and Clinical Oncology. 139, 5, p. 739-746 8 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)
2012

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., Yamamoto, K. I., Takata, M., Kitao, H. & Maehara, Y., 3 1 2012, : : DNA Repair. 11, 3, p. 247-258 12 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication

Sakasai, R., Sakai, A., Iimori, M., Kiyonari, S., Matsuoka, K., Kakeji, Y., Kitao, H. & Maehara, Y., 12 1 2012, : : Genes to Cells. 17, 12, p. 962-970 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer

Nakanishi, R., Kitao, H., Fujinaka, Y., Yamashita, N., Iimori, M., Tokunaga, E., Yamashita, N., Morita, M., Kakeji, Y. & Maehara, Y., 10 1 2012, : : Annals of Surgical Oncology. 19, 11, p. 3627-3635 9 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

High incidence and frequency of LOH are associated with aggressive features of high-grade HER2 and triple-negative breast cancers

Tokunaga, E., Okada, S., Yamashita, N., Akiyoshi, S., Kitao, H., Morita, M., Kakeji, Y. & Maehara, Y., 4 1 2012, : : Breast Cancer. 19, 2, p. 161-169 9 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

Sato, K., Ishiai, M., Toda, K., Furukoshi, S., Osakabe, A., Tachiwana, H., Takizawa, Y., Kagawa, W., Kitao, H., Dohmae, N., Obuse, C., Kimura, H., Takata, M. & Kurumizaka, H., 8 29 2012, : : EMBO Journal. 31, 17, p. 3524-3536 13 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer

Okada, S., Tokunaga, E., Kitao, H., Akiyoshi, S., Yamashita, N., Saeki, H., Oki, E., Morita, M., Kakeji, Y. & Maehara, Y., 5 1 2012, : : Annals of Surgical Oncology. 19, 5, p. 1499-1507 9 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

PARP and CSB modulate the processing of transcription-mediated DNA strand breaks

Sakai, A., Sakasai, R., Kakeji, Y., Kitao, H. & Maehara, Y., 1 1 2012, : : Genes and Genetic Systems. 87, 4, p. 265-272 8 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

The Q motif of fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function

Wu, Y., Sommers, J. A., Loiland, J. A., Kitao, H., Kuper, J., Kisker, C. & Brosh, R. M., 6 22 2012, : : Journal of Biological Chemistry. 287, 26, p. 21699-21716 18 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)