研究成果の検索

すべてのコンテンツを検索

研究成果 のフィルター

検索コンセプト
選択されたフィルター

出版年

  • 2018
  • 2017
  • 2016
  • 2013
  • 2012

著者

  • Hiroyuki Kitao
2018

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., 7 6 2018, : : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

研究成果: Contribution to journalArticle

6 引用 (Scopus)

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Inoue, Y., Yamashita, N., Kitao, H., Tanaka, K., Saeki, H., Oki, E., Oda, Y., Tokunaga, E. & Maehara, Y., 8 2018, : : Clinical Breast Cancer. 18, 4, p. e643-e650

研究成果: Contribution to journalArticle

3 引用 (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., 2 1 2018, : : Cancer Science. 109, 2, p. 264-271 8 p.

研究成果: Contribution to journalReview article

12 引用 (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., 10 2018, : : Clinical Breast Cancer. 18, 5, p. e1003-e1009

研究成果: Contribution to journalArticle

18 引用 (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., 12 1 2018, : : Scientific reports. 8, 1, 10888.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 10 2018, : : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)
2017

Activation of the FA pathway mediated by phosphorylation and ubiquitination

Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., 10 2017, : : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

研究成果: Contribution to journalReview article

8 引用 (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Ando, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16762.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16969.

研究成果: Contribution to journalArticle

2 引用 (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., 1 1 2017, : : Cancer Medicine. 6, 1, p. 258-266 9 p.

研究成果: Contribution to journalArticle

16 引用 (Scopus)
2016

Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)

Kitao, H., Matsuoka, K., Iimori, M., Tokunaga, E., Saeki, H., Oki, E., Miyamoto, Y., Baba, H. & Maehara, Y., 1 1 2016, : : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 8-14 7 p.

研究成果: Contribution to journalReview article

Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer

Tokunaga, E., Yamashita, N., Kitao, H., Tanaka, K., Taketani, K., Inoue, Y., Saeki, H., Oki, E., Oda, Y. & Maehara, Y., 2 1 2016, : : Breast. 25, p. 62-68 7 p.

研究成果: Contribution to journalArticle

6 引用 (Scopus)

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers

Maehara, Y., Oki, E., Saeki, H., Tokunaga, E., Kitao, H., Iimori, M., Niimi, S., Kataoka, Y., Emi, Y., Kakeji, Y., Baba, H. & Shirasaka, T., 7 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 7, p. 845-854 10 p.

研究成果: Contribution to journalReview article

Expression of APOBEC3B mRNA in primary breast cancer of Japanese women

Tokunaga, E., Yamashita, N., Tanaka, K., Inoue, Y., Akiyoshi, S., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 12 2016, : : PloS one. 11, 12, e0168090.

研究成果: Contribution to journalArticle

7 引用 (Scopus)

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Ito, S., Okano, S., Morita, M., Saeki, H., Tsutsumi, S., Tsukihara, H., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Kitao, H., Mimori, K. & Maehara, Y., 8 2016, : : Annals of Surgical Oncology. 23, Suppl 4, p. 508-515 8 p.

研究成果: Contribution to journalArticle

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Ito, S., Okano, S., Morita, M., Saeki, H., Tsutsumi, S., Tsukihara, H., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Kitao, H., Mimori, K. & Maehara, Y., 8 1 2016, : : Annals of Surgical Oncology. 23, p. 508-515 8 p.

研究成果: Contribution to journalArticle

25 引用 (Scopus)

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis

Otsu, H., Iimori, M., Ando, K., Saeki, H., Aishima, S., Oda, Y., Morita, M., Matsuo, K., Kitao, H., Oki, E. & Maehara, Y., 7 1 2016, : : Oncology (Switzerland). 91, 1, p. 31-40 10 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)

High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer

Sugiyama, M., Oki, E., Nakaji, Y., Tsutsumi, S., Ono, N., Nakanishi, R., Sugiyama, M., Nakashima, Y., Sonoda, H., Ohgaki, K., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Morita, M., Oda, Y. & Maehara, Y., 11 1 2016, : : Cancer Science. 107, 11, p. 1705-1716 12 p.

研究成果: Contribution to journalArticle

13 引用 (Scopus)

Impact of Expression of Vimentin and Axl in Breast Cancer

Tanaka, K., Tokunaga, E., Inoue, Y., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Oki, E., Oda, Y. & Maehara, Y., 12 1 2016, : : Clinical Breast Cancer. 16, 6, p. 520-526.e2

研究成果: Contribution to journalArticle

13 引用 (Scopus)

Oxaliplatin - A 10-year trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., 6 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 715-722 8 p.

研究成果: Contribution to journalReview article

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Iimori, M., Watanabe, S., Kiyonari, S., Matsuoka, K., Sakasai, R., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., 3 31 2016, : : Nature communications. 7, 11117.

研究成果: Contribution to journalArticle

13 引用 (Scopus)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Kitao, H., Morodomi, Y., Niimi, S., Kiniwa, M., Shigeno, K., Matsuoka, K., Kataoka, Y., Iimori, M., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., 5 3 2016, : : Scientific reports. 6, 25286.

研究成果: Contribution to journalArticle

14 引用 (Scopus)

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Kitao, H., Kiyonari, S., Limori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., 6 2016, : : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 707-714 8 p.

研究成果: Contribution to journalReview article

2 引用 (Scopus)
2013

Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells

Ikawa-Yoshida, A., Ando, K., Oki, E., Saeki, H., Kumashiro, R., Taketani, K., Ida, S., Tokunaga, E., Kitao, H., Morita, M. & Maehara, Y., 8 2013, : : Cancer Medicine. 2, 4, p. 447-456 10 p.

研究成果: Contribution to journalArticle

8 引用 (Scopus)

Involvement of ribonucleotide reductase-M1 in 5-fluorouracil.-induced DNA damage in esophageal cancer cell lines

Aoki, Y., Sakogawa, K., Hihara, J., Emi, M., Hamai, Y., Kono, K., Shi, L., Sun, J., Kitao, H., Ikura, T., Niida, H., Nakanishi, M., Okada, M. & Tashiro, S., 6 2013, : : International journal of oncology. 42, 6, p. 1951-1960 10 p.

研究成果: Contribution to journalArticle

6 引用 (Scopus)

Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

Nakashima, Y., Yoshinaga, K., Kitao, H., Ando, K., Kimura, Y., Saeki, H., Oki, E., Morita, M., Kakeji, Y., Hirahashi, M., Oda, Y. & Maehara, Y., 12 2013, : : Cancer Science. 104, 12, p. 1718-1725 8 p.

研究成果: Contribution to journalArticle

18 引用 (Scopus)

Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer

Nakanishi, R., Harada, J., Tuul, M., Zhao, Y., Ando, K., Saeki, H., Oki, E., Ohga, T., Kitao, H., Kakeji, Y. & Maehara, Y., 12 2013, : : International Journal of Clinical Oncology. 18, 6, p. 1042-1048 7 p.

研究成果: Contribution to journalArticle

37 引用 (Scopus)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Tuul, M., Kitao, H., Iimori, M., Matsuoka, K., Kiyonari, S., Saeki, H., Oki, E., Morita, M. & Maehara, Y., 2 1 2013, : : PloS one. 8, 2, e55361.

研究成果: Contribution to journalArticle

13 引用 (Scopus)

Vimentin as a poor prognostic factor for triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Aishima, S., Morita, M. & Maehara, Y., 5 2013, : : Journal of Cancer Research and Clinical Oncology. 139, 5, p. 739-746 8 p.

研究成果: Contribution to journalArticle

62 引用 (Scopus)
2012

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., Yamamoto, K. I., Takata, M., Kitao, H. & Maehara, Y., 3 1 2012, : : DNA Repair. 11, 3, p. 247-258 12 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication

Sakasai, R., Sakai, A., Iimori, M., Kiyonari, S., Matsuoka, K., Kakeji, Y., Kitao, H. & Maehara, Y., 12 2012, : : Genes to Cells. 17, 12, p. 962-970 9 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)

FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer

Nakanishi, R., Kitao, H., Fujinaka, Y., Yamashita, N., Iimori, M., Tokunaga, E., Yamashita, N., Morita, M., Kakeji, Y. & Maehara, Y., 10 2012, : : Annals of Surgical Oncology. 19, 11, p. 3627-3635 9 p.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

High incidence and frequency of LOH are associated with aggressive features of high-grade HER2 and triple-negative breast cancers

Tokunaga, E., Okada, S., Yamashita, N., Akiyoshi, S., Kitao, H., Morita, M., Kakeji, Y. & Maehara, Y., 4 2012, : : Breast Cancer. 19, 2, p. 161-169 9 p.

研究成果: Contribution to journalArticle

11 引用 (Scopus)

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

Sato, K., Ishiai, M., Toda, K., Furukoshi, S., Osakabe, A., Tachiwana, H., Takizawa, Y., Kagawa, W., Kitao, H., Dohmae, N., Obuse, C., Kimura, H., Takata, M. & Kurumizaka, H., 8 29 2012, : : EMBO Journal. 31, 17, p. 3524-3536 13 p.

研究成果: Contribution to journalArticle

45 引用 (Scopus)

Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer

Okada, S., Tokunaga, E., Kitao, H., Akiyoshi, S., Yamashita, N., Saeki, H., Oki, E., Morita, M., Kakeji, Y. & Maehara, Y., 5 2012, : : Annals of Surgical Oncology. 19, 5, p. 1499-1507 9 p.

研究成果: Contribution to journalArticle

10 引用 (Scopus)

PARP and CSB modulate the processing of transcription-mediated DNA strand breaks

Sakai, A., Sakasai, R., Kakeji, Y., Kitao, H. & Maehara, Y., 2012, : : Genes and Genetic Systems. 87, 4, p. 265-272 8 p.

研究成果: Contribution to journalArticle

12 引用 (Scopus)

The Q motif of fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function

Wu, Y., Sommers, J. A., Loiland, J. A., Kitao, H., Kuper, J., Kisker, C. & Brosh, R. M., 6 22 2012, : : Journal of Biological Chemistry. 287, 26, p. 21699-21716 18 p.

研究成果: Contribution to journalArticle

27 引用 (Scopus)