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出版年

  • 2019
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著者

  • Keiichi Nakayama
2019

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., 3 1 2019, : : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

研究成果: Contribution to journalArticle

2018

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., 6 2018, : : Genes to Cells. 23, 6, p. 418-434 17 p.

研究成果: Contribution to journalArticle

3 引用 (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Rothenberg, E. V., 12 1 2018, : : Nature Immunology. 19, 12, p. 1427-1440 14 p.

研究成果: Contribution to journalArticle

13 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: Contribution to journalArticle

2019

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K. I., 8 2019, : : EBioMedicine. 46, p. 150-159 10 p.

研究成果: Contribution to journalArticle

公開
3 引用 (Scopus)
2018

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., 10 15 2018, : : Neuroscience Letters. 685, p. 50-54 5 p.

研究成果: Contribution to journalArticle

1 引用 (Scopus)
2015

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., 8 3 2015, : : OncoImmunology. 4, 8

研究成果: Contribution to journalArticle

5 引用 (Scopus)

Tissue-specific expression of histone H3 variants diversified after species separation

Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H. & Ohkawa, Y., 9 17 2015, : : Epigenetics and Chromatin. 8, 1, 35.

研究成果: Contribution to journalArticle

21 引用 (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., 9 1 2015, : : Reproductive Biology. 15, 3, p. 131-138 8 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)
2018

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 2018, : : Life Science Alliance. 1, 6

研究成果: Contribution to journalArticle

4 引用 (Scopus)
2017

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, : : Nature. 541, 7636, p. 228 5 p., 541.

研究成果: Contribution to journalArticle

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., 7 17 2017, : : Nature communications. 8, 16114.

研究成果: Contribution to journalArticle

16 引用 (Scopus)
2018

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., 5 15 2018, : : Cell Reports. 23, 7, p. 1988-2000 13 p.

研究成果: Contribution to journalArticle

2 引用 (Scopus)
2015

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., 2 2 2015, : : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

研究成果: Contribution to journalArticle

60 引用 (Scopus)
2019

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., 4 1 2019, : : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

研究成果: Contribution to journalArticle

公開
7 引用 (Scopus)
2017

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., 4 1 2017, : : Molecular and cellular biology. 37, 8, e00470-16.

研究成果: Contribution to journalArticle

8 引用 (Scopus)
2015

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., 10 28 2015, : : Scientific reports. 5, 15876.

研究成果: Contribution to journalArticle

21 引用 (Scopus)
2019

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: Contribution to journalArticle

2018

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., 3 1 2018, : : Cancer Research. 78, 5, p. 1334-1346 13 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. および12人, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 3 12 2018, : : Cancer Cell. 33, 3, p. 355-367.e7

研究成果: Contribution to journalArticle

35 引用 (Scopus)
2015

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., 4 28 2015, : : Nature Neuroscience. 18, 5, p. 657-665 9 p.

研究成果: Contribution to journalArticle

127 引用 (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., 4 17 2015, : : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

研究成果: Contribution to journalArticle

15 引用 (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., 11 15 2015, : : Developmental Biology. 407, 2, p. 331-343 13 p.

研究成果: Contribution to journalArticle

2 引用 (Scopus)
2018

The promise of targeted proteomics for quantitative network biology

Matsumoto, M. & Nakayama, K., 12 1 2018, : : Current Opinion in Biotechnology. 54, p. 88-97 10 p.

研究成果: Contribution to journalReview article

9 引用 (Scopus)

Erratum: Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding (Immunity (2018) 48(6) (1119–1134.e7), (S1074761318301936) (10.1016/j.immuni.2018.04.024))

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 10 16 2018, : : Immunity. 49, 4, p. 782 1 p.

研究成果: Contribution to journalComment/debate

2 引用 (Scopus)
2015

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., 11 2015, : : STEM CELLS. 33, 11, p. 3327-3340 14 p.

研究成果: Contribution to journalArticle

10 引用 (Scopus)
2017

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., 12 9 2017, : : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

研究成果: Contribution to journalArticle

8 引用 (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. および4人, Zhu, L., Gao, D., Chen, L. & Zhou, D., 5 8 2017, : : Cancer Cell. 31, 5, p. 669-684.e7

研究成果: Contribution to journalArticle

55 引用 (Scopus)
2015

Phosphorylation of p27Kip1on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., 3 13 2015, : : Journal of Biological Chemistry. 290, 11, 1 p.

研究成果: Contribution to journalComment/debate

4 引用 (Scopus)
2017

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., 11 16 2017, : : Molecular Cell. 68, 4, p. 645-658.e5

研究成果: Contribution to journalArticle

14 引用 (Scopus)

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., 11 28 2017, : : Cell Reports. 21, 9, p. 2471-2486 16 p.

研究成果: Contribution to journalArticle

28 引用 (Scopus)
2019

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2019, : : JCI Insight. 4, 4, e125138.

研究成果: Contribution to journalArticle

9 引用 (Scopus)
2018

Correction: "UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation" [Molecular and Cellular Biology 36, 3, (2016) (394-406)] doi 10.1128/MCB.00809-15

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., 4 1 2018, : : Molecular and cellular biology. 38, 7, e00572-17.

研究成果: Contribution to journalComment/debate

2015

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., 2015, : : Oncotarget. 6, 2, p. 771-788 18 p.

研究成果: Contribution to journalArticle

27 引用 (Scopus)
2019

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., 12 16 2019, : : EMBO Journal. 38, 24, e102566.

研究成果: Contribution to journalArticle

2 引用 (Scopus)
2018

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., 2 6 2018, : : International journal of molecular sciences. 19, 2, 474.

研究成果: Contribution to journalArticle

8 引用 (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 6 19 2018, : : Immunity. 48, 6, p. 1119-1134.e7

研究成果: Contribution to journalArticle

26 引用 (Scopus)
2015

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. I. & Takeuchi, T., 10 16 2015, : : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

研究成果: Contribution to journalArticle

4 引用 (Scopus)
2019

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., 7 2019, : : Cancer Science. 110, 7, p. 2090-2099 10 p.

研究成果: Contribution to journalReview article

公開
7 引用 (Scopus)
2017

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., 1 20 2017, : : Scientific reports. 7, 41130.

研究成果: Contribution to journalArticle

7 引用 (Scopus)
2018

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., 4 13 2018, : : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

研究成果: Contribution to journalArticle

5 引用 (Scopus)

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., 2 1 2018, : : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

研究成果: Contribution to journalArticle

19 引用 (Scopus)
2015

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., 8 1 2015, : : Genes to Cells. 20, 8, p. 667-674 8 p.

研究成果: Contribution to journalArticle

8 引用 (Scopus)
2017

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., 1 1 2017, : : EMBO Reports. 18, 1, p. 123-137 15 p.

研究成果: Contribution to journalArticle

17 引用 (Scopus)
2015

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., 5 22 2015, : : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

研究成果: Contribution to journalArticle

13 引用 (Scopus)
2017

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., 1 12 2017, : : Nature. 541, 7636, p. 228-232 5 p.

研究成果: Contribution to journalArticle

190 引用 (Scopus)
2018

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: Contribution to journalArticle

公開
8 引用 (Scopus)
2019

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., 5 2019, : : Genes to Cells. 24, 5, p. 354-365 12 p.

研究成果: Contribution to journalArticle

2 引用 (Scopus)
2018

Hidden peptides encoded by putative noncoding RNAs

Matsumoto, A. & Nakayama, K. I., 1 1 2018, : : Cell structure and function. 43, 1, p. 75-83 9 p.

研究成果: Contribution to journalShort survey

16 引用 (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., 8 1 2018, : : Journal of cell science. 131, 15

研究成果: Contribution to journalArticle

5 引用 (Scopus)