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出版年

  • 2020
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著者

  • Yusaku Nakabeppu
2020

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., 1 1 2020, : : PloS one. 15, 1, e0227501.

研究成果: ジャーナルへの寄稿記事

公開
2019

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (版) & Ninomiya, T. (版), 5 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

研究成果: 著書/レポートタイプ著書

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

2 引用 (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., 5 7 2019, Advances in Experimental Medicine and Biology. Springer, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)
2018

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., 12 1 2018, : : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., 8 2018, : : Annals of Neurology. 84, 2, p. 208-224 17 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi

Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., 1 2018, : : Brain Pathology. 28, 1, p. 58-71 14 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis

Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., 6 2018, : : Neuropathology. 38, 3, p. 247-259 13 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice

Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., 5 1 2018, : : Neuroscience. 377, p. 87-97 11 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)
2017

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., 12 1 2017, : : Scientific Reports. 7, 1, 6528.

研究成果: ジャーナルへの寄稿記事

公開

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., 7 2017, : : PloS one. 12, 7, e0181687.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer

Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., 7 1 2017, : : Lung Cancer. 109, p. 52-57 6 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., 1 1 2017, : : Cancer Science. 108, 1, p. 108-115 8 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., 12 1 2017, : : Brain Research. 1676, p. 77-82 6 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., 12 1 2017, : : Scientific reports. 7, 1, 17762.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., 9 1 2017, : : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis

Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Sakumi, K., Ono, R., Nakabeppu, Y. & Nishigori, C., 2 1 2017, : : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.

研究成果: ジャーナルへの寄稿レター

4 引用 (Scopus)

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. & Toyokuni, S., 11 2017, : : Pathology International. 67, 11, p. 564-574 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., 1 15 2017, : : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu, Y., Ohta, E. & Abolhassani, N., 6 1 2017, : : Free Radical Biology and Medicine. 107, p. 151-158 8 p.

研究成果: ジャーナルへの寄稿評論記事

20 引用 (Scopus)

Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.

Nakabeppu, Y., 4 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.

研究成果: 著書/レポートタイプへの貢献

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., 1 1 2017, : : Cancer Medicine. 6, 1, p. 258-266 9 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes

Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., 10 2017, : : DNA Repair. 58, p. 13-20 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation

Kajitani, K., Yanagimoto, K. & Nakabeppu, Y., 10 1 2017, : : Psychopharmacology. 234, 19, p. 2919-2927 9 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., 2 17 2017, : : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
2016
28 引用 (Scopus)
5 引用 (Scopus)

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. および8人, Aldhekri, H., Meffre, E., Mizui, M., Tsokos, G. C., Manis, J. P., Al-Herz, W., Wallace, S. S. & Geha, R. S., 11 1 2016, : : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., 9 13 2016, : : Scientific reports. 6, 32849.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 6 10 2016, : : Scientific reports. 6, 27164.

研究成果: ジャーナルへの寄稿コメント/討論

Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration

Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., 6 5 2016, : : AIMS Molecular Science. 3, 3, p. 325-337 13 p.

研究成果: ジャーナルへの寄稿評論記事

公開

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease

Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., 11 29 2016, : : Scientific reports. 6, 37889.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., 3 10 2016, : : Scientific reports. 6, 22991.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 1 1 2016, : : JCI Insight. 1, 15, e87781.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., 9 22 2016, : : JCI insight. 1, 15, 15 p., e87781.

研究成果: ジャーナルへの寄稿記事

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine

Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., 10 1 2016, : : Free Radical Biology and Medicine. 99, p. 385-391 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice

Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., 10 1 2016, : : Genes to Cells. 21, 10, p. 1030-1048 19 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)