@article{d0c58a51e6ce4e9180837efbc70a62de,
title = "A β-hairpin peptide with pH-controlled affinity for tumor cells",
abstract = "Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.",
author = "Nishimura, {Shin Nosuke} and Kei Nishida and Masaru Tanaka",
note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research (KAKENHI) (No. JP19H05720, JP20K20201, and JP21K18066) from the Japan Society for the Promotion of Science (JSPS) and {\textquoteleft}{\textquoteleft}Dynamic Alliance Open Innovation Bridging Human, Environment and Materials{\textquoteright}{\textquoteright} from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). This research was also supported by a Grant-in-Aid for the Nakayama Foundation for Human Science and the Fukuoka Public Health Promotion Organization Cancer Research Fund. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry",
year = "2022",
month = jan,
day = "14",
doi = "10.1039/d1cc06218b",
language = "English",
volume = "58",
pages = "505--508",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "4",
}