A bedtime dose of ARB was better than a morning dose in improving baroreflex sensitivity and urinary albumin excretion - The J-TOP study

Kazuo Eguchi, Motohiro Shimizu, Satoshi Hoshide, Kazuyuki Shimada, Kazuomi Kario

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

The hypothesis that the bedtime dosing of angiotensin receptor blocker (ARB) is superior to morning dose in improving baroreflex sensitivity (BRS) and urinary albumin/creatinine ratio (UACR) was tested in this study. Baroreflex sensitivity was measured at baseline and at 6th month (N = 109) and was found to increase in the bedtime-dose group (P = .004), but not in the morning-dose group. The correlations between the change in BRS and the change in UACR were insignificant in the morning-dose group (r = 0.17, P = .26), but were significant in the bedtime-dose group (r = -0.29, P = .04). In conclusion, the improvement of BRS could be one of the mechanisms by which bedtime dosing of ARB confers renal protection.

本文言語英語
ページ(範囲)488-492
ページ数5
ジャーナルClinical and Experimental Hypertension
34
7
DOI
出版ステータス出版済み - 12 7 2012

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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