A bedtime dose of ARB was better than a morning dose in improving baroreflex sensitivity and urinary albumin excretion - The J-TOP study

Kazuo Eguchi, Motohiro Shimizu, Satoshi Hoshide, Kazuyuki Shimada, Kazuomi Kario

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

The hypothesis that the bedtime dosing of angiotensin receptor blocker (ARB) is superior to morning dose in improving baroreflex sensitivity (BRS) and urinary albumin/creatinine ratio (UACR) was tested in this study. Baroreflex sensitivity was measured at baseline and at 6th month (N = 109) and was found to increase in the bedtime-dose group (P = .004), but not in the morning-dose group. The correlations between the change in BRS and the change in UACR were insignificant in the morning-dose group (r = 0.17, P = .26), but were significant in the bedtime-dose group (r = -0.29, P = .04). In conclusion, the improvement of BRS could be one of the mechanisms by which bedtime dosing of ARB confers renal protection.

本文言語英語
ページ(範囲)488-492
ページ数5
ジャーナルClinical and Experimental Hypertension
34
7
DOI
出版ステータス出版済み - 12月 7 2012

All Science Journal Classification (ASJC) codes

  • 内科学
  • 生理学

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