A bedtime dose of ARB was better than a morning dose in improving baroreflex sensitivity and urinary albumin excretion - The J-TOP study

Kazuo Eguchi, Motohiro Shimizu, Satoshi Hoshide, Kazuyuki Shimada, Kazuomi Kario

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

The hypothesis that the bedtime dosing of angiotensin receptor blocker (ARB) is superior to morning dose in improving baroreflex sensitivity (BRS) and urinary albumin/creatinine ratio (UACR) was tested in this study. Baroreflex sensitivity was measured at baseline and at 6th month (N = 109) and was found to increase in the bedtime-dose group (P = .004), but not in the morning-dose group. The correlations between the change in BRS and the change in UACR were insignificant in the morning-dose group (r = 0.17, P = .26), but were significant in the bedtime-dose group (r = -0.29, P = .04). In conclusion, the improvement of BRS could be one of the mechanisms by which bedtime dosing of ARB confers renal protection.

元の言語英語
ページ(範囲)488-492
ページ数5
ジャーナルClinical and Experimental Hypertension
34
発行部数7
DOI
出版物ステータス出版済み - 12 7 2012

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Baroreflex
Angiotensin Receptor Antagonists
Albumins
Creatinine
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

これを引用

A bedtime dose of ARB was better than a morning dose in improving baroreflex sensitivity and urinary albumin excretion - The J-TOP study. / Eguchi, Kazuo; Shimizu, Motohiro; Hoshide, Satoshi; Shimada, Kazuyuki; Kario, Kazuomi.

:: Clinical and Experimental Hypertension, 巻 34, 番号 7, 07.12.2012, p. 488-492.

研究成果: ジャーナルへの寄稿記事

Eguchi, Kazuo ; Shimizu, Motohiro ; Hoshide, Satoshi ; Shimada, Kazuyuki ; Kario, Kazuomi. / A bedtime dose of ARB was better than a morning dose in improving baroreflex sensitivity and urinary albumin excretion - The J-TOP study. :: Clinical and Experimental Hypertension. 2012 ; 巻 34, 番号 7. pp. 488-492.
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