A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis

Hiroki Hamano, Takeshi Matsushige, Hirofumi Inoue, Madoka Hoshide, Hikaru Kobayashi, Fumitaka Kohno, Momoko Oka, Takashi Ichiyama, Shoichi Ohga, Kazunobu Ouchi, Shunji Hasegawa

研究成果: ジャーナルへの寄稿記事

抄録

Immunoglobulin A vasculitis (IgAV) occasionally induces central nervous system (CNS) involvement, which is usually transient with no sequelae except for hemorrhagic stroke. It is thought to be useful to measure serum and cerebrospinal fluid (CSF) cytokine levels for better understanding the pathological condition in encephalopathy, but there have been no reports in acute encephalopathy with IgAV. We describe an 8-year-old boy with IgAV who had neurological sequelae after complication of acute encephalopathy, focusing on the cytokine profiles and unique biphasic findings of magnetic resonance imaging. He presented with status epilepticus and mildly intensified area in the occipital lobe on the fluid-attenuated inversion recovery view. Arterial spin labeling (ASL) revealed the reduction of cerebral blood flow in the left hemisphere. On day 5 of illness, these abnormal findings disappeared, but delayed hyperintensity lesions on diffusion-weighted images newly emerged. Furthermore, CSF interleukin (IL)-6 levels markedly increased without elevated levels of IL-10 during the acute phase of disease. He suffered from long-lasting hemiparesis and intellectual impairment. In conclusion, acute encephalopathy with IgAV could cause neurological sequelae by prolonged seizure, and elevated IL-6 in CSF and laterality of cerebral blood flow in ASL might be useful to predict the prognosis of CNS dysfunction of IgAV.

元の言語英語
ページ(範囲)270-271
ページ数2
ジャーナルJournal of Clinical Neuroscience
67
DOI
出版物ステータス出版済み - 9 1 2019

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Vasculitis
Immunoglobulin A
Brain Diseases
Cerebrovascular Circulation
Cerebrospinal Fluid
Interleukin-6
Central Nervous System
Cytokines
Occipital Lobe
Sick Leave
Status Epilepticus
Acute Disease
Paresis
Interleukin-10
Seizures
Stroke
Magnetic Resonance Imaging
Serum

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

これを引用

Hamano, H., Matsushige, T., Inoue, H., Hoshide, M., Kobayashi, H., Kohno, F., ... Hasegawa, S. (2019). A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis. Journal of Clinical Neuroscience, 67, 270-271. https://doi.org/10.1016/j.jocn.2019.05.061

A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis. / Hamano, Hiroki; Matsushige, Takeshi; Inoue, Hirofumi; Hoshide, Madoka; Kobayashi, Hikaru; Kohno, Fumitaka; Oka, Momoko; Ichiyama, Takashi; Ohga, Shoichi; Ouchi, Kazunobu; Hasegawa, Shunji.

:: Journal of Clinical Neuroscience, 巻 67, 01.09.2019, p. 270-271.

研究成果: ジャーナルへの寄稿記事

Hamano, H, Matsushige, T, Inoue, H, Hoshide, M, Kobayashi, H, Kohno, F, Oka, M, Ichiyama, T, Ohga, S, Ouchi, K & Hasegawa, S 2019, 'A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis', Journal of Clinical Neuroscience, 巻. 67, pp. 270-271. https://doi.org/10.1016/j.jocn.2019.05.061
Hamano, Hiroki ; Matsushige, Takeshi ; Inoue, Hirofumi ; Hoshide, Madoka ; Kobayashi, Hikaru ; Kohno, Fumitaka ; Oka, Momoko ; Ichiyama, Takashi ; Ohga, Shoichi ; Ouchi, Kazunobu ; Hasegawa, Shunji. / A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis. :: Journal of Clinical Neuroscience. 2019 ; 巻 67. pp. 270-271.
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